Chinese cobra (Naja atra) SVPLA<sub>2</sub> promotes muscle inflammation via RPL35A-mediated translational reprogramming. [PDF]
Commun BiolLiu J +9 more
europepmc +1 more source
LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes. [PDF]
Arthritis Res TherChae HY +12 more
europepmc +1 more source
<i>Houttuynia cordata</i> triggers type I interferon signaling to promote host defense against <i>Acinetobacter baumannii</i> infection via mTORC1 activation. [PDF]
Biochem Biophys RepXie Q +6 more
europepmc +1 more source
Construction of a Duck Intestinal Organoid Culture System: From Crypt Isolation to Medium Optimization. [PDF]
Animals (Basel)Tang R +7 more
europepmc +1 more source
Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580 [PDF]
FEBS Letters, 1999 SB203580 (4‐(4‐fluorophenyl)‐2‐(4‐methylsulfinylphenyl)‐5‐(4‐pyridyl)1H‐imidazole) is widely used as a specific inhibitor of p38 mitogen‐activated protein kinase (MAPK). Here, we report that SB203580 activates the serine/threonine kinase Raf‐1 in quiescent smooth muscle cells in a dose‐dependent fashion.
G Daum, A W Clowes
exaly +5 more sources
SB203580 promote EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway [PDF]
Journal of Cellular Biochemistry, 2001 AbstractMAP kinases have important role in PC12 cell differentiation, since the activities of both extracellular regulated protein kinase (ERK) and p38 have been indicated as necessary signal for PC12 cell differentiation. Epidermal growth factor (EGF) and NGF both activate ERK and p38 in PC12 cells, but only NGF trigger differentiation.
L New
exaly +5 more sources
The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs) [PDF]
FEBS Letters, 1998 SB203580 is a recognised inhibitor of p38-MAPKs. Here, we investigated the effects of SB203580 on cardiac SAPKs/JNKs. The IC50 for inhibition of p38-MAPK stimulation of MAPKAPK2 was approximately 0.07 microM, whereas that for total SAPK/JNK activity was ...
Angela CLERK, P H Sugden
exaly +2 more sources
Related searches:
The p38 MAPK inhibitor, SB203580, inhibits cell invasion by Neospora caninum
Parasitology Research, 2016The Apicomplexan parasite Neospora caninum is an obligate intracellular parasitic protozoan. It can cause severe diseases in a number of animals throughout the world. Infection with N. caninum leads to abortions in pregnant animals and neuromuscular disorders of newborns which cause great economic losses to animal husbandry.
Pengtao Gong +2 more
exaly +3 more sources
SB203580 reverses adrenomedullin's effect on proliferation and apoptosis in cultured mesangial cells
European Journal of Pharmacology, 1999Adrenomedullin is a potent vasodilatory peptide that has a variety of effects in a number of different systems including kidney. In cultured rat glomerular mesangial cells adrenomedullin increases cAMP, decreases proliferation and increases apoptosis. Associated with the anti-proliferative and apoptotic effects, adrenomedullin also causes a decrease in
N, Parameswaran +3 more
openaire +2 more sources
Influence of SB203580 on cell apoptosis and P38MAPK in renal ischemia/reperfusion injury
Journal of Huazhong University of Science and Technology [Medical Sciences], 2006The effects of SB203580 (SB) with different concentrations at different time points on renal function, apoptosis, P38MAPK activity and the expression, as well as the P38MAPK substrates in renal ischemia/reperfusion injury were investigated. Forty-nine rats were divided into 7 groups at random (n = 7 in each group) according to the durations of ischemia/
Rongshan, Li +3 more
openaire +2 more sources