Results 171 to 180 of about 19,858 (214)

GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling. [PDF]

Inflamm Res
Feng Y, Cao Z, Zhang F, Zhou X, Aol L, Su L, He L.   +6 more
europepmc   +1 more source

SB203580 Promote EGF-Stimulated Early Morphological Differentiation in PC12 Cell Through Activating ERK Pathway [PDF]

Journal of Cellular Biochemistry, 2001
AbstractMAP kinases have important role in PC12 cell differentiation, since the activities of both extracellular regulated protein kinase (ERK) and p38 have been indicated as necessary signal for PC12 cell differentiation. Epidermal growth factor (EGF) and NGF both activate ERK and p38 in PC12 cells, but only NGF trigger differentiation.
Liguo New, L New
exaly   +4 more sources

Raf-1 Is Activated by the p38 Mitogen-Activated Protein Kinase Inhibitor, SB203580 [PDF]

FEBS Letters, 1999
SB203580 (4‐(4‐fluorophenyl)‐2‐(4‐methylsulfinylphenyl)‐5‐(4‐pyridyl)1H‐imidazole) is widely used as a specific inhibitor of p38 mitogen‐activated protein kinase (MAPK). Here, we report that SB203580 activates the serine/threonine kinase Raf‐1 in quiescent smooth muscle cells in a dose‐dependent fashion.
Alexander W Clowes, Günter Daum, Jessie Deou   +2 more
exaly   +3 more sources

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The p38 MAPK inhibitor, SB203580, inhibits cell invasion by Neospora caninum

Parasitology Research, 2016
The Apicomplexan parasite Neospora caninum is an obligate intracellular parasitic protozoan. It can cause severe diseases in a number of animals throughout the world. Infection with N. caninum leads to abortions in pregnant animals and neuromuscular disorders of newborns which cause great economic losses to animal husbandry.
Xiaoxia, Jin, Pengtao, Gong, Guojiang, Li, Xichen, Zhang, Jianhua, Li   +4 more
openaire   +2 more sources

The p38 MAP Kinase Inhibitor SB203580 Enhances Nuclear Factor-Kappa B Transcriptional Activity by a Non-Specific Effect Upon the ERK Pathway

British Journal of Pharmacology, 2000
1 In the present study we investigated a possible role for the p38 mitogen-activated protein (MAP) kinase pathway in mediating nuclear factor-kappa B (NF-kappa B) transcriptional activity in the erythroleukaemic cell line TF-1.
Edo Vellenga, Wiebe Kruijer, Albertus T J Wierenga   +2 more
exaly   +2 more sources

SB203580 reverses adrenomedullin's effect on proliferation and apoptosis in cultured mesangial cells

European Journal of Pharmacology, 1999
Adrenomedullin is a potent vasodilatory peptide that has a variety of effects in a number of different systems including kidney. In cultured rat glomerular mesangial cells adrenomedullin increases cAMP, decreases proliferation and increases apoptosis. Associated with the anti-proliferative and apoptotic effects, adrenomedullin also causes a decrease in
N, Parameswaran, W S, Spielman, D P, Brooks, P, Nambi   +3 more
openaire   +2 more sources

Influence of SB203580 on cell apoptosis and P38MAPK in renal ischemia/reperfusion injury

Journal of Huazhong University of Science and Technology [Medical Sciences], 2006
The effects of SB203580 (SB) with different concentrations at different time points on renal function, apoptosis, P38MAPK activity and the expression, as well as the P38MAPK substrates in renal ischemia/reperfusion injury were investigated. Forty-nine rats were divided into 7 groups at random (n = 7 in each group) according to the durations of ischemia/
Rongshan, Li, Tao, Ding, Xiaocheng, Liu, Caixia, Li   +3 more
openaire   +2 more sources

Inhibition of the Cardiac p38-MAPK Pathway by SB203580 Delays Ischemic Cell Death

Journal of Cardiovascular Pharmacology, 2000
We report that SB203580 (SB), a specific inhibitor of p38-MAPK, protects pig myocardium against ischemic injury in an in vivo model. SB was applied by local infusion into the subsequently ischemic myocardium for 60 min before a 60-min period of coronary occlusion followed by 60-min reperfusion (index ischemia).
M, Barancik, P, Htun, C, Strohm, S, Kilian, W, Schaper   +4 more
openaire   +2 more sources

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

Inflammopharmacology, 2018
Acute pancreatitis in pregnancy (APIP) can lead to multiple maternal and fetal organ injury and mitogen-activated protein kinase (MAPK) signaling pathway may be involved in it; however, whether APIP can result in acute lung injury and P38MAPK signaling pathway is involved in the pathogenesis has not been elucidated.
Yu Zhou, Hongmiao Xia, Liang Zhao, Fangchao Mei, Man Li, Yundong You, Kailiang Zhao, Weixing Wang   +7 more
openaire   +2 more sources