Results 181 to 190 of about 18,824 (215)

Inhibition of the Cardiac p38-MAPK Pathway by SB203580 Delays Ischemic Cell Death

Journal of Cardiovascular Pharmacology, 2000
We report that SB203580 (SB), a specific inhibitor of p38-MAPK, protects pig myocardium against ischemic injury in an in vivo model. SB was applied by local infusion into the subsequently ischemic myocardium for 60 min before a 60-min period of coronary occlusion followed by 60-min reperfusion (index ischemia).
M, Barancik, P, Htun, C, Strohm, S, Kilian, W, Schaper   +4 more
openaire   +2 more sources

SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy

Inflammopharmacology, 2018
Acute pancreatitis in pregnancy (APIP) can lead to multiple maternal and fetal organ injury and mitogen-activated protein kinase (MAPK) signaling pathway may be involved in it; however, whether APIP can result in acute lung injury and P38MAPK signaling pathway is involved in the pathogenesis has not been elucidated.
Yu Zhou, Hongmiao Xia, Liang Zhao, Fangchao Mei, Man Li, Yundong You, Kailiang Zhao, Weixing Wang   +7 more
openaire   +2 more sources

p38 Inhibitor SB203580 sensitizes the resveratrol‐induced apoptosis in human lung adenocarcinoma (A549) cells

Journal of Biochemical and Molecular Toxicology, 2012
AbstractBased on our recent findings that resveratrol, a natural plant polyphenol found in red grape skins as well as other food products, induces apoptosis via a caspase‐independent intrinsic pathway in human lung adenocarcinoma cells, this study is designed to explore whether SB203580, a p38 inhibitor, potentiates the resveratrol‐induced apoptosis of
Haiyang Li
exaly   +4 more sources

SB203580 inhibits epithelial–mesenchymal transition and pulmonary fibrosis in a rat silicosis model

Toxicology Letters, 2016
To investigate the role of p38 MAPK in silicosis, we explored the effects of SB203580 as a specific inhibitor of p38 MAPK in the silicosis model in rats. Rats were exposed to 50mg/ml silica intratracheally. From the first day after instillation, rats were injected with SB203580 1mg/kg/d.
Wang, Yan, Li, Xiaoli, An, Guoliang, Zhu, Zhonghui, Liang, Di, Lian, Ximeng, Niu, Piye, Chen, Li, Tian, Lin   +8 more
openaire   +2 more sources

Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells

Bioorganic & Medicinal Chemistry Letters, 2013
The p38α mitogen-activated protein kinase (MAPK) inhibitor SB203580 had been reported to enhance the cardiomyogenesis of human embryonic stem cells (hESCs). To investigate if tri-substituted imidazole analogues of SB203580 are equally effective inducers for cardiomyogenesis of hESCs, and if there is a correlation between p38α MAPK inhibition and ...
Low, J.-L., Jürjens, G., Seayad, J., Seow, J., Ting, S., Laco, F., Reuveny, S., Oh, S., Chai, C.L.L.   +8 more
openaire   +2 more sources

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK

Apoptosis: an International Journal on Programmed Cell Death, 2011
SB203580 is a well-known inhibitor of p38 mitogen-activated protein kinase (MAPK). However, it can suppress cell proliferation in a p38 MAPK independent manner. The inhibitory mechanism remains unknown. Here, we showed that SB203580 induced autophagy in human hepatocellular carcinoma (HCC) cells.
George Chen, Lai Paul B S, Chen George G   +2 more
exaly   +3 more sources

SB203580 enhances the RV-induced loss of mitochondrial membrane potential and apoptosis in A549 cells

SPIE Proceedings, 2012
Resveratrol (RV), a naturally occurring phytoalexin, is known to possess a wide spectrum of chemopreventive and chemotherapeutic effects in various stages of human tumors. p38, a member of the mitogen-activated protein kinase (MAPK) superfamily, is always activated by some extracellular stimulus to regulate many cellular signal transduction pathways,
Hai-yang Li, Cai-ping Zhuang, Xiao-ping Wang, Tong-sheng Chen   +3 more
openaire   +1 more source

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

Antiviral Research, 2014
Dengue virus (DENV) infection could lead to dengue fever (DF), dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). The disease outcome is controlled by both viral and host factors. Inflammation mediators from DENV-infected cells could contribute to increased vascular permeability, leading to severe DHF/DSS.
Yilong, Fu, Andy, Yip, Peck Gee, Seah, Francesca, Blasco, Pei-Yong, Shi, Maxime, Hervé   +5 more
openaire   +2 more sources

The p38 MAPK inhibitor SB203580 abrogates TNF-mediated expansion of regulatory T cells

The Journal of Immunology, 2017
Abstract CD4+FoxP3+ regulatory T cells (Tregs) represent a major cellular mechanism of immune evasion of tumor. There is compelling evidence that TNF is able to activate and expand Tregs through TNFR2. However, it remains unclear which TNFR2 signaling pathway(s) is required for the activation of Tregs.
Xin Chen, Tianzhen He
openaire   +1 more source

The p38 MAPK inhibitor, SB203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical

Basic Research in Cardiology, 2000
There is debate concerning the involvement of p38 mitogen activated protein kinase (MAPK) in the mediation of ischaemic preconditioning. Pharmacological inhibition of p38 MAPK with SB203580 has been reported to block preconditioning in some studies but not in others.
, Gary Baxter, Mihaela M Mocanu
exaly   +3 more sources