Results 191 to 200 of about 18,824 (215)

The p38 MAPK Inhibitor SB203580 Blocks Adenosine A1 Receptor-Induced Attenuation of In Vivo Myocardial Stunning

Cardiovascular Drugs and Therapy, 2004
There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium.
Yukihiro, Yoshimura, Gentian, Kristo, Byron J, Keith, Salik A, Jahania, Robert M, Mentzer, Robert D, Lasley   +5 more
openaire   +2 more sources

Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38 [PDF]

Cellular Signalling, 2003
Previous work has shown that increased phosphorylation of eukaryotic initiation factor (eIF) 4E at Ser209 in the C-terminal loop of the protein is observed in response to cellular stress.
Simon J Morley
exaly   +1 more source

[SB203580 reduces proinflammatory cytokine production in rats after cardiopulmonary bypass].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011
To examine the changes in P38MAPK during and after cardiopulmonary bypass (CPB) and the effect of SB203580, a specific P38MAPK inhibitor, on CPB-induced pulmonary inflammatory response.Fifty-four SD rats were randomized into 3 groups (each=18), namely sham CPB group, CPB group, and SB203580 group in which rats underwent CPB with SB203580 pretreatment ...
Xiao, Dong, Jian-Jun, Xu, Xiong, He
openaire   +1 more source

[The protective effects of SB203580 against mortality and radiation induced intestinal injury of mice].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 ...
Jian-hui, Chang, Heng, Zhang, Fang-xia, Guan, Yue-ying, Wang, De-guan, Li, Hong-ying, Wu, Cheng-chun, Wang, Chang-hui, Zhou, Zhi-bin, Zhai, Lu, Lu, Xiao-chun, Wang, Qi, Hou, Ai-min, Meng   +12 more
openaire   +1 more source

Cilostazol and SB203580 combination: Targeting ER stress and p38MAPK signaling in Alzheimer's disease mouse model

European Journal of Pharmacology
Endoplasmic reticulum (ER) stress and mitogen-activated protein kinase (p38MAPK) signaling contribute to neuronal inflammation, oxidative stress, and apoptosis, driving neurodegeneration in Alzheimer's disease (AD). These pathways present potential therapeutic targets.
May Magdy Ali, Rabab Hamed Sayed, Walaa Wadie, Reham Atef Mohammed   +3 more
openaire   +2 more sources

[P38 MAPK inhibitor SB203580 attenuates the toxicity of ropivacaine on PC12 cells].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2019
To investigate the effect of SB203580, a p38MAPK specific inhibitor, on ropivacaine-induced cytotoxicity in PC12 cells.
 Methods: PC12 cells were divided into three groups: the normal group (Group N), cells were cultured for 48 h; the ropivacaine group (Group R), cells were cultured with 15 mmol/L ropivacaine hydrochloride for 48 h; the ropivacaine ...
Yuan, Chen, E, Wang, Zhihua, Sun, Zongbin, Song, Zhi, Ye, Zhong, Zhang   +5 more
openaire   +1 more source

SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1–42 into hippocampus of mice

Metabolic Brain Disease, 2016
A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selective inhibitor of p38MAPK, may protect
Jiejie, Guo, Lan, Chang, Chenli, Li, Mengmeng, Li, Peiyun, Yan, Zhiping, Guo, Chuang, Wang, Qin, Zha, Qinwen, Wang   +8 more
openaire   +2 more sources

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

Biochemical and Biophysical Research Communications, 1999
Phosphorylation of p53 at serine 389 has been shown to be responsive uniquely to UV but not gamma irradiation. This report describes identification of the UV-responsive p38MAPK protein as a serine 389 kinase. The immunoprecipitated p38MAPK from UV-irradiated murine embryonic testicular carcinoma F9 cells phosphorylated the serine 392 residue but not ...
D, Keller, X, Zeng, X, Li, M, Kapoor, M S, Iordanov, Y, Taya, G, Lozano, B, Magun, H, Lu   +8 more
openaire   +2 more sources

[Mechanism of p38 mitogen-activated protein kinase inhibitor SB203580 to glucocorticoid sensitivity].

Zhonghua yi xue za zhi, 2013
To establish a model of cigarette smoke exposure to asthmatic rats and glucocorticoid resistance induced by nicotine in alveolar epithelioid cells A549 and study the mechanism for the change of glucocorticoid sensitivity induced by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580.Sixty Wistar rats were randomly divided into 4 groups ...
Wen, Li, Jiang-tao, Lin, Li-chao, Sun, Tong-liang, Zhou, Lan, Zhang, Jun, Shu   +5 more
openaire   +1 more source

Cytosolic Phospholipase A2 Activation by the p38 Kinase Inhibitor SB203580 in Rabbit Aortic Smooth Muscle Cells

The Journal of Pharmacology and Experimental Therapeutics, 2001
SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole] is widely used as a specific inhibitor of p38 mitogen-activated protein kinase (MAPK). Here we report that SB203580, which blocked p38 kinase activation elicited by anisomycin, increased the phosphorylation and activity of cytosolic phospholipase A2 (cPLA2) and ...
S, Fatima, Z, Khandekar, J H, Parmentier, K U, Malik   +3 more
openaire   +2 more sources