Results 101 to 110 of about 19,858 (214)

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Cell Death and Disease
p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including SB203580 and SB202190, induce cell death in some cancer cell-types through ...
Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton   +8 more
doaj   +1 more source

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

Frontiers in Pharmacology, 2018
Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive.
Ya-wei Zhao, Ya-wei Zhao, Yu-qin Pan, Yu-qin Pan, Ming-ming Tang, Wen-juan Lin, Wen-juan Lin   +6 more
doaj   +1 more source

Role of SB203580 in the regulation of human esophageal cancer cells under the effection of Diosgenin.

International journal of clinical and experimental medicine, 2015
In order to investigate the mechanism of human esophageal Eca109 cells induced by Diosgenin (Dio), the p38 specific inhibitor SB203580 was used to inhibit the expression of p38 and Western blot was employed to detect the effect of SB203580 in Eca109 cells. MTT experiments were executed to detect the proliferation of the cells.
Weiliang, Ding, Yancai, Jiang, Yaping, Jiang, Taofeng, Zhu, Ying, Xu, Wenjie, Jiang, Wenjiao, Zhu, Zhian, Tang, Zhijun, Ge, Tieliang, Ma, Yongfei, Tan   +10 more
openaire   +1 more source

Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathway in vivo and in vitro

Journal of Ginseng Research
Background: Ginsenosides have been used in traditional Chinese medicine to treat fractures. Ginsenoside Re, a key component of P. ginseng, however, the molecular mechanisms underlying these effects remain inadequately understood.
Yunjia Wang, Gengming Zhang, Linhua Deng, Hongqi Zhang, Emmanuel Alonge, Zhongjing Jiang   +5 more
doaj   +1 more source

Protective effects of the p38 MAPK inhibitor SB203580 on NMDA-induced injury in primary cerebral cortical neurons

Molecular Medicine Reports, 2014
The p38 pathway, which is important in mitogen-activated protein kinase (MAPK) family protein signaling, leads to mitochondrial dysfunction and activation of caspase-3. B-cell lymphoma 2 (Bcl‑2) family members are involved in the regulation of activities associated with the survival and death of neurons through apoptosis and have important functions in
Xue-Wen, Liu, En-Fei, Ji, Peng, He, Rui-Xian, Xing, Bu-Xian, Tian, Xi-Dong, Li   +5 more
openaire   +3 more sources

Neuroprotective effects of SB203580 (p38 MAP kinase inhibitor) against Endothelin-1-induced retinal ganglion cell death

, 2020
Purpose: Endothelin-1 (ET-1) is a vasoactive peptide contributing to neurodegeneration in glaucoma, however, the underlying mechanisms are not completely understood.
Krishnamoorthy, Vignesh, Chaphalkar, Renuka, Krishnamoorthy, Raghu, He, Shaoqing, Kodati, Bindu   +4 more
core  

Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580

, 2004
Activated mast cells generate multiple cytokines but it is not known if these can be differentially regulated by pharmacological agents. We report here that the glucocorticoid dexamethasone (DEX) preferentially inhibited Ag-induced expression of IL-4 and
Flanagan, B. F., Dearman, R. J., Swindle, E. J., Kimber, I., Koranteng, R. D., Coleman, J. W., Davis, B. J.   +6 more
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The volatile oil of Acorus tatarinowii schott significantly attenuates neuroinflammatory damage in a rat model of tourette syndrome by inhibiting the p38 MAPK/NLRP3/STAT3 signaling pathway

Frontiers in Pharmacology
BackgroundAcorus tatarinowii Schott holds a prominent position in Traditional Chinese Medicine, with its earliest record found in the ancient Chinese pharmacopeia, the Shennong’s Classic of Materia Medica.
Xing Wei, Xing Wei, Kexin Sun, Peng Feng, Shuang Huang, Bing Jiang, Min Cui, Yuanhuan Chen, Fuchun Xue, Yuezhen He, Jingxi Yao, Jing Shang, Hao Mei, Yanqing Ding, Yongyan Tian, Guangyu Guo, Nan Yang, Zhenggang Shi   +17 more
doaj   +1 more source

Immunoblot analysis of caspase 3 and hepatocytes viability in response to SB203580 and SP600125.

, 2013
Hepatyocytes were pre-treated with 10 µM SB203580 and SP600125 for 15 min, then treated with As (10 µM), taurine (25 mM, added 1 h prior to As treatment) for 8 h.
Joydeep Das (361941), Jyotirmoy Ghosh (361942), Prasenjit Manna (361944), Parames C. Sil (361946)   +3 more
core   +1 more source

Effects of TGF-β2, Y-27632 and SB203580 on actin stress fibers in HTM cells.

, 2015
HTM cells were pretreated with 10 μM Y-27632 (B, E) or 10 μM SB203580 (C, F) for 30 min, and then stimulated with 2.5 ng/ml TGF-β2 (D-F) for 24 h, stained with phalloidin-FITC, and observed by fluorescence microscopy. Scale bar: 50 μm.
Naoki Ohtsu (709195), Kenichi Kimoto (709196), Takanori Kameda (709193), Tomokazu Fujimoto (709192), Nanako Awai-Kasaoka (709194), Hidenobu Tanihara (559962), Toshihiro Inoue (559958), Miyuki Inoue-Mochita (709191)   +7 more
core   +1 more source