Results 81 to 90 of about 15,652 (174)

Protective effects of the p38 MAPK inhibitor SB203580 on NMDA-induced injury in primary cerebral cortical neurons

Molecular Medicine Reports, 2014
The p38 pathway, which is important in mitogen-activated protein kinase (MAPK) family protein signaling, leads to mitochondrial dysfunction and activation of caspase-3. B-cell lymphoma 2 (Bcl‑2) family members are involved in the regulation of activities associated with the survival and death of neurons through apoptosis and have important functions in
Xue-Wen, Liu, En-Fei, Ji, Peng, He, Rui-Xian, Xing, Bu-Xian, Tian, Xi-Dong, Li   +5 more
openaire   +3 more sources

P38 mitogen-activated protein kinase inhibition attenuates mechanical stress induced lung injury via up-regulating AQP5 expression in rats

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to detect aquaporin-5 (AQP5) expression and evaluate the role of the p38-MAPK signalling pathway in mechanical ventilation-associated lung injury. Rats were randomly divided into 5 groups.
Yang Liu, Yuelan Wang, Xiumei Song, Ling Dong, Wei Wang, Hongchao Wu   +5 more
doaj   +1 more source

β-catenin expression in areca quid chewing-associated oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells

Journal of the Formosan Medical Association, 2012
Nuclear localization of β-catenin is known to associate with malignant transformation of many squamous cell carcinomas. The aim of this study was to compare β-catenin expression in normal human oral epithelium and areca quid chewing associated oral ...
Shiuan-Shinn Lee, Chung-Hung Tsai, Lo-Lin Tsai, Ming-Chih Chou, Ming-Yung Chou, Yu-Chao Chang   +5 more
doaj   +1 more source

Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in endoplasmic reticulum stress (ERS) and inflammation, which may play an important role in the pathogenesis of type 2 diabetes (T2DM).
Xiaowei Wei, Nan Gu, Nan Feng, Xiaohui Guo, Xiaowei Ma   +4 more
doaj   +1 more source

p38 MAPK 抑制剂通过抑制JNK 活性抑制培养的小脑颗粒神经元凋亡

Zhongshan Daxue xuebao. Yixue kexue ban, 2001
【目的】研究特异性p38 分裂原激活的蛋白激酶(MAPK)抑制剂SB203580 对低钾诱导的小脑颗粒神经元凋亡的 作用。【方法】把体外培养的小脑颗粒神经元从含去极化浓度钾离子(KCl 25 mmo l·L-1)的培养基中转移至低钾培养基(KCl 5 mmol·L-1)中诱导神经元凋亡。凝胶电泳分析DNA 片段, SAPK/ JNK 分析盒测定c-Jun N-末端蛋白激酶(JNK)活性。【结 果】低钾诱导小脑颗粒神经元的具有典型形态学和生化特征的凋亡。特异性的p38 MAPK ...
黎明涛, 王文雅, 孙　娟, 唐孝礼, 苏兴文, 邱鹏新, 颜光美   +6 more
doaj  

The Effect of SB203580, an Inhibitor of P38MAPK, on HK-2 Cells TEMT

Hong Kong Journal of Nephrology, 2015
Jia, L., Yang, X.P., Lin, Z.F., Tang, Y.L., Yang, R., Ma, L.   +5 more
openaire   +1 more source

Dynamics in the p38α MAP Kinase–SB203580 Complex Observed by Liquid‐State NMR Spectroscopy

Angewandte Chemie International Edition, 2008
Honndorf, Valerie S., Coudevylle, Nicolas, Laufer, Stefan, Becker, Stefan, Griesinger, Christian   +4 more
openaire   +6 more sources

RTA‑408 induces p38‑dependent apoptosis and suppresses cell viability in hepatocellular carcinoma cells. [PDF]

Hepat Oncol
Chen WC, Chong YB, Tsai HP, Tseng TT, Wang CY, Kuo SH, Yang SF, Wu CC.   +7 more
europepmc   +1 more source

BDNF Protects Against Neuronal Damage Induced by TNF and β-Amyloid Peptides by Targeting JNK Activation. [PDF]

Neurochem Res
Ramírez-Olvera A, Almazán JL, Pérez-Martínez L, Pedraza-Alva G.   +3 more
europepmc   +1 more source

NF-KappaB65380;p38 MAPK和JNK通路在运动神经损伤 引起的大鼠病理性疼痛中的作用及机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】 探讨肿瘤坏死因子α(TNF-α)激活的下游信号转导途径-核转录因子kappaB (NF-κB)65380; JNK和p38 MAPK是否参与运动神经损伤引起的大鼠病理性疼痛的形成,并探讨其可能机制65377;【方法】 采用痛行为学测试和免疫荧光组织化学方法,观察鞘内注射NF-κB 抑制剂(PDTC)65380; p38 MAPK 抑制剂(SB203580)和JNK 抑制剂(SP600125)对腰5脊神经前根切断(L5-VRT)大鼠机械性痛过敏及腰5背根神经节(DRG)内电压门控钠通道(Nav1.
doaj