Results 81 to 90 of about 18,824 (215)

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, Volume 13, Issue 42, 28 July 2026.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Reversal of Adrenergic Desensitization in Prenatally Stressed Rats by P38 Map Kinase Inhibitor, SB203580

The FASEB Journal, 2008
We previously reported a defect in beta adrenergic responsiveness in cardiac myoctes isolated from pre‐natally stressed rats (PS) following restraint stress (R) (PS+R). We now report a reversal of the blunted beta adrenergic responsiveness in PS + R with the P38 MAP kinase inhibitor, SB203580, in vivo.
Fangping Chen, Hong Kan, Sherry Xie, Robert J Beto, Bradford E Warden, Abnash C Jain, Mitchell S Finkel   +6 more
openaire   +1 more source

Antiischemic effects of SB203580 are mediated through the inhibition of p38α mitogen-activated protein kinase:Evidence from ectopic expression of an inhibition-resistant kinase [PDF]

, 2001
The aim of the present study was to determine whether the attenuation of myocardial ischemic injury by SB203580 is due to the inhibition of p38 mitogen-activated protein kinase (MAPK) or to other documented nonspecific effects of the drug.
Avkiran, Metin, Quinlan, R A, Avkiran, M, Avkiran, M; id_orcid, Marber, MS, Cohen, P, Marber, Michael S., Martin, Jody L., Cohen, Philip; id_orcid, Martin, J L, Quinlan, Roy A., Quinlan, RA, Martin, JL, Marber, M S; id_orcid   +13 more
core   +1 more source

The mechanism of Qijing Mingmu decoction on cellular senescence of conjunctivochalasis

BMC Complementary Medicine and Therapies, 2023
Background Qijing Mingmu decoction (QJMM), a compound Chinese medicine preparation, which consists of Lycium barbarum, Polygonatum, Ophiopogon japonicus, Poria cocos, Glycyrrhiza, Eclipta prostrata and Ligusticum striatum, has been confirmed to be ...
Minhong Xiang, Jiang Liu, Kai Ma, Yongyi Sha, Yueping Zhan, Wei Zhang, Xueqing Kong   +6 more
doaj   +1 more source

Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38‐ATF3 Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Resveratrol dose‐dependently upregulates GDF15 expression in murine and human cells via the p38‐ATF3 signaling axis. In high‐fat diet fed mice, resveratrol elevates systemic and tissue GDF15 levels, thereby reducing food intake and weight gain and conferring resistance to diet‐induced obesity. This study identifies a novel p38‐ATF3‐GDF15 axis mediating
Liufeng Mao, Yunliang Hou, Weifang Liu, Jianbin Chen, Wanli Hu, Wengong Jiang, Tao Nie   +6 more
wiley   +1 more source

SB203580 treatment reduces liver enzymes in DENV-infected mice. [PDF]

, 2016
Mice were infected with DENV and treated with 2%DMSO or SB203580. The uninfected control group was also treated with 2%DMSO. Seven days after infection, blood was collected and sera prepared to estimate liver transaminases. (A) ALT, and (B) AST.
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1

Journal of Pharmacological Sciences, 2018
Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear.
Yui Yamazaki, Kyoko Arita, Shinichi Harada, Shogo Tokuyama   +3 more
doaj   +1 more source

Exploring the Distinct Regulatory Actions and Molecular Pathways of Coptisine Through Network Pharmacology: Insights Into Its Influence on Platelet Activation and Thrombus Development

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
The methodological framework of this study integrates computational network pharmacology analysis with subsequent experimental validation. ABSTRACT To investigate the potential targets and underlying mechanisms of coptisine in regulating platelet activation and thrombosis by integrating an approach combining network pharmacology and experimental ...
Yanli Liu, Ming Qian, Hui Yang, Shiyu Qian, Depin Li, Xiaoli Zhou, Xian Yang, Yihai Liu   +7 more
wiley   +1 more source

p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis

Oncology Reports, 2006
Sulindac sulfone (exisulind), is a promising anticancer agent because of its ability to induce apoptosis in a variety of malignant cell types and its minimal toxicity to normal cells. The induction of apoptosis is thought to account for the growth inhibitory effect of exisulind. The mitogen-activated protein kinase (MAPK) cascade has been implicated in
Soo-Jeong, Lim, Young-Ju, Lee, Eunmyong, Lee   +2 more
openaire   +3 more sources

Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non‑obese type 2 diabetic Goto‑Kakizaki rats [PDF]

, 2019
International audienceDiabetic cardiomyopathy, especially myocardial ischemia reperfusion (I/R) injury, is a major cause of morbidity and mortality in type 2 diabetic patients.
Kumphune, Sarawut, Kijtawornrat, Anusak, Adulyaritthikul, Punyanuch, Petchdee, Soontaree, Kongpol, Kantapich, Prompunt, Eakkapote, Sanit, Jantira, Nokkaew, Nuttikarn, Mongkolpathumrat, Podsawee, Barrère-Lemaire, Stéphanie   +9 more
core   +1 more source