Results 81 to 90 of about 19,858 (214)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, Volume 20, Issue 9, Page 2135-2162, September 2026.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

SB203580 decreases parasite micronemal protein secretion.

, 2015
Treatment consisted in incubation of sporozoites for 2 h in complete cell culture medium with SB203580 (25 μM) or DMSO. Pre-treatment consisted in first incubating sporozoites with SB203580 (25 μM) or DMSO for 1 h.
Thibaut de Sablet (192383), Anne Silvestre (692734), Françoise I. Bussière (692733), Yves Le Vern (334998), Sonia Lacroix-Lamandé (238567), Alisson Niepceron (328723), Fabrice Laurent (238581), Fabien Brossier (249897)   +7 more
core   +1 more source

Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF‐κB Signaling and Activating Atg5‐Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
Graphical Abstract. Juanbi Tang (JBT) suppresses the p38MAPK/NF‐κB signaling pathway in disc‐infiltrating macrophages, simultaneously activating Atg5‐dependent autophagy. Autophagic degradation of p62/SQSTM1 consolidates NF‐κB inhibition through an autophagy–p62–NF‐κB regulatory module, facilitating macrophage M1‐to‐M2 polarization.
Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu   +7 more
wiley   +1 more source

SB203580, a P38 MAPK Inhibitor, Blocks in vitro Invasion by Human Gastric SNU-638 Cells

Cancer Research and Treatment, 2002
The role of P38 mitogen-activated protein kinase (MAPK) in gastric cancer invasion has not yet been determined. In this study, we examined the effects of SB203580, a specific P38 MAPK inhibitor, on the in vitro invasion of gastric cancer and upon the molecules involved in this process.Human gastric cancer SNU-638 cells were maintained in RPMI 1640 ...
Ju Chae, Park, Hyeon Gyeung, Yoo, Hong Su, Kim, Min A, Jung, Mi Ha, Kim, Sang Won, Han, Kee Oh, Chay, Boo Ahn, Shin, Bong Whan, Ahn, Young Do, Jung   +9 more
openaire   +2 more sources

Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line [PDF]

, 2017
p38 mitogen-activated protein kinase (MAPK) belongs to the MAPK superfamily, phosphorylating serine and/or threonine residues of the target proteins. The activation of p38 MAPK leads to cell growth, differentiation, inflammation, survival or apoptosis ...
Boyacı, İhsan, YERLİKAYA, AZMİ, Zülfü Bayhan, OKUR, EMRAH, ZEREN, SEZGİN, DÜZGÜN, ŞÜKRÜ AYDIN, Düzgün, Şükrü Aydın, BOYACI, İHSAN, Şükrü Aydın Düzgün, Sezgin Zeren, Emrah Okur, Azmi Yerlikaya, İhsan Boyacı, BAYHAN, ZÜLFÜ   +13 more
core   +1 more source

Norepinephrine inhibits cell cycle re‐entry of neonatal rat ventricular cardiomyocytes characterized by the absence of de novo nestin expression

Physiological Reports
The p38α/β MAPK inhibitor SB203580 in the presence of a phorbol ester (protein kinase C activator) induced cell cycle re‐entry of two subpopulations of neonatal rat ventricular cardiomyocytes (NNVMs) distinguished by the absence or de novo nestin ...
Adrien Aubry, Mariana Kebbe, Aya Al‐Katat, Louis Villeneuve, Angelino Calderone   +4 more
doaj   +1 more source

The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells

Frontiers in Immunology, 2018
There is now compelling evidence that tumor necrosis factor (TNF) preferentially activates and expands CD4+Foxp3+ regulatory T cells (Tregs) through TNF receptor type II (TNFR2).
Tianzhen He, Shuoyang Liu, Shaokui Chen, Jingyi Ye, Xueqiang Wu, Zhaoxiang Bian, Xin Chen   +6 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Role of SLDE in G-CSF 3'UTR mediates increase of mRNA stability induced by SB203580

, 2013
顆粒性白血球群落刺激因子(G-CSF)為造血性醣蛋白家族中的一員，也是一種細胞激素，主要由巨噬細胞及單核球細胞所分泌，具有促進噬中性白血球分化、增生及移動的功能。細胞受到LPS刺激活化p38 MAPK會使G-CSF mRNA穩定度增加，增加G-CSF表現。G-CSF mRNA的穩定度主要由 3''UTR的ARE及SLDE所調控。許多研究顯示給予SB203580抑制p38 MAPK活性後，會使在3’UTR帶有ARE的mRNA半衰期變短，進而降低其表現量。但是本實驗室先前的研究結果發現 ...
Li, Huai-Tzu, 黎懷慈
core  

SB203580 and ruxolitinib attenuated the effects of rAIF-1 on A549 cell proliferation, migration, and production of IL-6 and VEGF.

, 2022
(A) Culture medium levels of IL-6 secreted by A549 cells. Ru: Ruxolitinib; SB: SB203580. Data are shown as mean ± SD. *** P P B) Culture medium levels of VEGF secreted by A549 cells. Ru: Ruxolitinib; SB: SB203580. Data are shown as mean ± SD.
Cuimin Zhu (12116799), Lingling Wang (66269), Yanhong Liu (124527), Xing Zhao (219333), Huachuan Zheng (14266110)   +4 more
core   +1 more source