Results 41 to 50 of about 19,858 (214)

Exercise Improves Nonalcoholic Fatty Liver Disease in T2DM Mice by Inhibiting Ferroptosis Through p38 MAPK Signaling Pathway

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveTo explore the mechanism of treadmill exercise against type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD) based on the regulator effects of exercise on ferroptosis.MethodsEight 8-week-old male m/m mice were used as ...
ZHANG Bao-Wen, LI Ying, GAO Yuan, SHENG Ke-Yan, WANG Zhi, KOU Xian-Juan   +5 more
doaj   +1 more source

Triggering of Suicidal Erythrocyte Death by Zosuquidar

Cellular Physiology and Biochemistry, 2015
Background: The P-glycoprotein inhibitor zosuquidar (LY335979) is clinically used to augment the effect of cytostatic drugs on suicidal tumor cell death or apoptosis. The present study explored whether the substance is cytotoxic to erythrocytes.
Marilena Briglia, Antonella Fazio, Caterina Faggio, Florian Lang   +3 more
doaj   +1 more source

Antiischemic effects of SB203580 are mediated through the inhibition of p38α mitogen-activated protein kinase:Evidence from ectopic expression of an inhibition-resistant kinase

, 2001
The aim of the present study was to determine whether the attenuation of myocardial ischemic injury by SB203580 is due to the inhibition of p38 mitogen-activated protein kinase (MAPK) or to other documented nonspecific effects of the drug.
Avkiran, Metin, Quinlan, R A, Avkiran, M, Avkiran, M; id_orcid, Marber, MS, Cohen, P, Marber, Michael S., Martin, Jody L., Cohen, Philip; id_orcid, Martin, J L, Quinlan, Roy A., Quinlan, RA, Martin, JL, Marber, M S; id_orcid   +13 more
core   +1 more source

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala

Research Results in Pharmacology
Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580
Konstantin Y. Kalitin, Alexander A. Spasov, Olga Y. Mukha   +2 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

The p38 MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin 6 expression in macrophages

Central European Journal of Immunology, 2015
The p38 mitogen-activated protein kinase (MAPK) plays a key role in lipopolysaccharide (LPS)-induced signal transduction pathways that lead to inflammatory cytokine synthesis in macrophages; however, whether the inhibition of p38 MAPK regulates LPS-induced inflammatory cytokine expression in different types of macrophages remains the subject of debate.
Shi, Qinghai, Cheng, Liping, Liu, Zhengxiang, Hu, Keyan, Ran, Jihua, Ge, Di, Fu, Jianfeng   +6 more
openaire   +2 more sources

Effects of PD98059, SP600125 or SB203580 on the PGE₁-stimulated release of IL-6 in MC3T3-E1 cells.

, 2022
Effects of PD98059, SP600125 or SB203580 on the PGE1-stimulated release of IL-6 in MC3T3-E1 cells.
Rie Matsushima-Nishiwaki (480791), Kazuhiko Fujita (530079), Daiki Nakashima (9579791), Tetsu Kawabata (4036874), Kumiko Tanabe (750228), Takanobu Otsuka (579057), Osamu Kozawa (480798), Junko Tachi (11927163), Go Sakai (2469661), Hiroki Iida (750230), Haruhiko Tokuda (750221), Woo Kim (3483326), Gen Kuroyanagi (750222)   +12 more
core   +1 more source

Role of p38 activation in changes of nitric oxide production in rat biceps femoris muscle during metabolic syndrome

Сучасні медичні технології
Transcriptional changes in organism and muscles especially during development of metabolic syndrome (MetS) is still highly understudied. Role of p38 MAPK activation during MetS is highly debatable.
O. Ye. Akimov, A. O. Mykytenko
doaj   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source