Results 41 to 50 of about 18,824 (215)

Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-κB pathway

Journal of Biomedical Science, 2010
Background Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expression, as well as the possible ...
Wang Bao-Wei, Shyu Kou-Gi, Lin Chiu-Mei, Chang Hang   +3 more
doaj   +1 more source

The effect of inhibiting p38 MAPK on the expression of genes related to enamel development in mice

口腔疾病防治, 2021
Objective To study the effect of p38 mitogen activated protein kinase (p38 MAPK) on the expression of genes related to enamel development in the enamel epithelium and to provide a basis for the study of the molecular mechanism of enamel development ...
LUO Xiaona, LIU Xianghui, WANG Bo, LIU Xin, XIE Xiaohua   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Triggering of Suicidal Erythrocyte Death by Zosuquidar

Cellular Physiology and Biochemistry, 2015
Background: The P-glycoprotein inhibitor zosuquidar (LY335979) is clinically used to augment the effect of cytostatic drugs on suicidal tumor cell death or apoptosis. The present study explored whether the substance is cytotoxic to erythrocytes.
Marilena Briglia, Antonella Fazio, Caterina Faggio, Florian Lang   +3 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

SB203580 treatment reduces DENV-induced liver pathology in DENV-infected mice. [PDF]

, 2016
Mice were infected with DENV and treated with 2%DMSO or SB203580 dissolved in 2%DMSO. The uninfected control group was also treated with 2%DMSO. Seven days after infection, liver tissues were collected in 10% formalin for histopathological analysis and H&
Sansanee Noisakran (109150), Aunchalee Sirimontaporn (2266525), Thawornchai Limjindaporn (104984), Gopinathan Pillai Sreekanth (2266528), Pa-thai Yenchitsomanus (134210), Aporn Chuncharunee (482767), Jutatip Panaampon (324334)   +6 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Effects of TGF-β2, Y-27632 and SB203580 on COL1A2 induction in HTM cells. [PDF]

, 2015
HTM cells were pretreated with 10 μM Y-27632 or 10 μM SB203580 for 30 min, and then stimulated with 2.5 ng/ml TGF-β2 for 24 h. Data are shown as means ± SE. *P < 0.05 and **P < 0.01 calculated using the Tukey—Kramer HSD test.
Naoki Ohtsu (709195), Kenichi Kimoto (709196), Takanori Kameda (709193), Tomokazu Fujimoto (709192), Nanako Awai-Kasaoka (709194), Hidenobu Tanihara (559962), Toshihiro Inoue (559958), Miyuki Inoue-Mochita (709191)   +7 more
core   +1 more source

Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala

Research Results in Pharmacology
Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580
Konstantin Y. Kalitin, Alexander A. Spasov, Olga Y. Mukha   +2 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source