Results 11 to 20 of about 15,652 (174)
β, β-Dimethylacrylshikonin Triggers Caspase-Mediated Cell Apoptosis via Heme Oxygenase-1 Upregulation and ERK/p38 Activation in Prostate Cancer. [PDF]
J Cell Mol MedABSTRACT β, β‐Dimethylacrylshikonin (DMAS), a natural naphthoquinone derivative isolated from the root of a biennial herb belonging to the family Boraginaceae, has been demonstrated to exhibit anti‐cancer and anti‐inflammatory features. Yet, the effects of DMAS on restraining the progression of prostate cancer (PC) remain mostly elusive.
Weng WC +6 more
europepmc +2 more sources
Viruses, 2021 Mayaro virus (MAYV) hijacks the host’s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK1/2 have emerged as crucial cellular factors implicated in different stages of the viral cycle.
Madelaine Sugasti-Salazar +3 more
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In Vitro Evaluation of the Inhibitory Effects of Linarin on Histamine-Induced Expression of Proinflammatory Cytokines, Mucin 5AC, and Aquaporin 5 in Human Nasal and Bronchial Epithelial Cells. [PDF]
Kaohsiung J Med SciABSTRACT Allergic rhinitis and asthma are two prevalent chronic allergic conditions in children. Linarin, a glycosylated flavonoid derived from various plants, exhibits a wide range of biological activities. This study aimed to investigate the therapeutic potential of linarin against allergic rhinitis and asthma.
Mi XJ, Wang J, Qi JQ.
europepmc +2 more sources
Inhibition of p38 MAPK Signaling Regulates the Expression of EAAT2 in the Brains of Epileptic Rats
Frontiers in Neurology, 2018 Seizures induce the release of excitatory amino acids (EAAs) from the intracellular fluid to the extracellular fluid, and the released EAAs primarily comprise glutamic acid (Glu) and asparaginic acid (Asp).
Zhang Yang +11 more
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Cellular Physiology and Biochemistry, 2017 Background & Aims: Our previous studies have provided evidence that p38 mitogen-activated protein kinase (MAPK) is involved in total parenteral nutrition (TPN)-associated complications, but its exact effects and mechanisms have not been fully ...
Yong-Tao Xiao +4 more
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Nanosilicates Enhanced Periodontal Angiogenesis by Regulating Microtubule Dynamic-Mediated STAT3 Pathway. [PDF]
Cell ProlifNanosilicates triggered MAP4‐dependent microtubule remodelling via the ROS/MAPK pathway, shifting microtubules into a dynamic active state, which subsequently promoted activation of the STAT3 pathway, ultimately facilitating periodontal angiogenesis.
Shang L, Hu Y, Ge S.
europepmc +2 more sources
Ginnalin A and SB203580 show additive effect on Hep-3B hepatocellular carcinoma cell line [PDF]
Turkish Journal of Biochemistry, 2018 Abstract Objective Investigation of the anticarcinogenic effects of natural products with low toxicity is very important in the development of new therapeutic strategies against cancer. Ginnalin A (GA) is one of the most important phenolic compounds of
Hasibe Vural, Pınar Özden, Ebru Avcı
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Molekulare Wirkweise von SB203580 in Mammakarzinom-Zellen
, 2021 Dem Molekül p38 wurden bereits tumorpromovierende Eigenschaften zugeordnet. Ebenso finden sich Darstellungen der Kinase als Tumorsuppressor in der Literatur. Um die zum Teil gegensätzlichen Einschätzungen von p38 einordnen zu können ist es essentiell, das verwendete Werkzeug zur Untersuchung – den p38 Inhibitor SB203580 – genau zu kennen, ebenso wie ...
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Brain and Behavior, 2019 Objective This study aimed to investigate the effect of the p38 mitogen‐activated protein kinase (p38MAPK) signaling pathway on olfactory mucosa function and apoptosis of olfactory sensory neurons (OSNs) in an allergic rhinitis (AR) mouse model.
Xian Gao, Na Li, Jisheng Zhang
doaj +1 more source
Cells, 2021 Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg2+ deficiency affects chemosensitivity of cancer cells.
Saki Onuma +5 more
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