Molekulare Wirkweise von SB203580 in Mammakarzinom-Zellen [PDF]
, 2021 Dem Molekül p38 wurden bereits tumorpromovierende Eigenschaften zugeordnet. Ebenso finden sich Darstellungen der Kinase als Tumorsuppressor in der Literatur. Um die zum Teil gegensätzlichen Einschätzungen von p38 einordnen zu können ist es essentiell, das verwendete Werkzeug zur Untersuchung – den p38 Inhibitor SB203580 – genau zu kennen, ebenso wie ...
Engelhardt, Josef Siegfried
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In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580 [PDF]
International Journal of COPD, 2016 Aihong Meng,1 Xiaopeng Zhang,2 Siyu Wu,1 Mingxia Wu,1 Jing Li,1 Xixin Yan,1 Kamilla Kopec-Harding,3 Jiakai Wu41Respiratory Division, The Second Hospital of Hebei Medical University, 2Department of Thoracic Surgery, Hebei Province General Hospital ...
Meng AH +7 more
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Ginnalin A and SB203580 show additive effect on Hep-3B hepatocellular carcinoma cell line [PDF]
Turkish Journal of Biochemistry, 2018 Abstract Objective Investigation of the anticarcinogenic effects of natural products with low toxicity is very important in the development of new therapeutic strategies against cancer. Ginnalin A (GA) is one of the most important phenolic compounds of
Hasibe Vural, Pınar Özden, Ebru Avcı
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SB203580 Modulates p38 MAPK Signaling and Dengue Virus-Induced Liver Injury by Reducing MAPKAPK2, HSP27, and ATF2 Phosphorylation. [PDF]
PLoS ONE, 2016 Dengue virus (DENV) infection causes organ injuries, and the liver is one of the most important sites of DENV infection, where viral replication generates a high viral load.
Gopinathan Pillai Sreekanth +6 more
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Reduction of Insulin-Stimulated Glucose Uptake in L6 Myotubes by the Protein Kinase Inhibitor SB203580 Is Independent of p38MAPK Activity [PDF]
Endocrinology, 2005 AbstractInsulin increases glucose uptake through translocation of the glucose transporter GLUT4 to the plasma membrane. We previously showed that insulin activates p38MAPK, and inhibitors of p38MAPKα and p38MAPKβ (e.g. SB203580) reduce insulin-stimulated glucose uptake without affecting GLUT4 translocation.
Antonescu, C. N. +7 more
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Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia. [PDF]
Acta neurologica Scandinavica, 2004 Focal cerebral ischemia activates intracellular signaling pathways including the mitogen-activated protein kinase p38, which may be involved in the process of ischemic brain injury. In this study, the effect of pretreatment with the p38-inhibitor SB203580 on infarct size and blood-brain barrier (BBB) breakdown was investigated with magnetic resonance ...
F, Lennmyr +4 more
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SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma [PDF]
International Journal of Molecular Sciences, 2021 Subepithelial fibrosis is a component of the remodeling observed in the bronchial wall of patients diagnosed with asthma. In this process, human bronchial fibroblasts (HBFs) drive the fibroblast-to-myofibroblast transition (FMT) in response to transforming growth factor-β1 (TGF-β1), which activates the canonical Smad-dependent signaling.
Milena Paw +7 more
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Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus [PDF]
BioMed Research International, 2014 The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF)αin the hypothalamus of ewes during prolonged inflammation. Inflammation was induced by the administration of lipopolysaccharide (LPS) (400 ng/kg) over 7 days.
Andrzej P. Herman +5 more
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In vitro modeling of COPD inflammation and limitation of p38 inhibitor - SB203580.
International journal of chronic obstructive pulmonary disease, 2016 Systemic inflammation and steroid resistance are the hallmarks of COPD. We examined the impact of p38 inhibitor (SB203580) in in vitro assays of systemic inflammation using pulmonary cells and patients' sera.Data from 66 COPD patients and 15 age-/sex-matched healthy controls were compared.
Meng, Aihong +7 more
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SB203580 decreases parasite motility. [PDF]
, 2015 (A) Effect of SB203580 on sporozoite trail deposits during parasite gliding. Treatment: sporozoites placed on glass slides covered with gelatin were incubated for 1 h in the presence of SB203580 (25 μM) or DMSO.
Thibaut de Sablet (192383) +7 more
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