Results 11 to 20 of about 19,858 (214)

Molekulare Wirkweise von SB203580 in Mammakarzinom-Zellen [PDF]

, 2021
Dem Molekül p38 wurden bereits tumorpromovierende Eigenschaften zugeordnet. Ebenso finden sich Darstellungen der Kinase als Tumorsuppressor in der Literatur. Um die zum Teil gegensätzlichen Einschätzungen von p38 einordnen zu können ist es essentiell, das verwendete Werkzeug zur Untersuchung – den p38 Inhibitor SB203580 – genau zu kennen, ebenso wie ...
Engelhardt, Josef Siegfried
openaire   +3 more sources

Ginnalin A and SB203580 show additive effect on Hep-3B hepatocellular carcinoma cell line [PDF]

Turkish Journal of Biochemistry, 2018
Abstract Objective Investigation of the anticarcinogenic effects of natural products with low toxicity is very important in the development of new therapeutic strategies against cancer. Ginnalin A (GA) is one of the most important phenolic compounds of
Hasibe Vural, Pınar Özden, Ebru Avcı
openaire   +4 more sources

Reduction of Insulin-Stimulated Glucose Uptake in L6 Myotubes by the Protein Kinase Inhibitor SB203580 Is Independent of p38MAPK Activity [PDF]

Endocrinology, 2005
AbstractInsulin increases glucose uptake through translocation of the glucose transporter GLUT4 to the plasma membrane. We previously showed that insulin activates p38MAPK, and inhibitors of p38MAPKα and p38MAPKβ (e.g. SB203580) reduce insulin-stimulated glucose uptake without affecting GLUT4 translocation.
Antonescu, C. N., Huang, C., Niu, W., Liu, Z., Eyers, P. A., Heidenreich, K. A., Bilan, P. J., Klip, A.   +7 more
openaire   +3 more sources

Increased brain injury and vascular leakage after pretreatment with p38-inhibitor SB203580 in transient ischemia.

Acta neurologica Scandinavica, 2004
Focal cerebral ischemia activates intracellular signaling pathways including the mitogen-activated protein kinase p38, which may be involved in the process of ischemic brain injury. In this study, the effect of pretreatment with the p38-inhibitor SB203580 on infarct size and blood-brain barrier (BBB) breakdown was investigated with magnetic resonance ...
F, Lennmyr, A, Ericsson, P, Gerwins, H, Ahlström, A, Terént   +4 more
openaire   +3 more sources

In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580

International Journal of COPD, 2016
Aihong Meng,1 Xiaopeng Zhang,2 Siyu Wu,1 Mingxia Wu,1 Jing Li,1 Xixin Yan,1 Kamilla Kopec-Harding,3 Jiakai Wu41Respiratory Division, The Second Hospital of Hebei Medical University, 2Department of Thoracic Surgery, Hebei Province General Hospital ...
Meng AH, Zhang XP, Wu SY, Wu MX, Li J, Yan XX, Kopec-Harding K, Wu JK   +7 more
doaj   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis-Associated Metabolic Disorders in a GPR81-Dependent Manner. [PDF]

Adv Sci (Weinh)
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Zheng C, Li X, Li S, Xing C, Cao C.
europepmc   +2 more sources

p38 Inhibitor SB203580 Inhibits HEV Infection and Prevents HEV-Related Adverse Pregnancy Outcomes in a Pregnant Rabbit Model. [PDF]

Liver Int
Background and Aims Hepatitis E virus (HEV) infection during pregnancy can lead to severe adverse pregnancy outcomes including stillbirth, preterm birth, abortion, maternal death, and vertical transmission.
Li M, Wan W, Song Z, Wang P, Sun W, He Q, Zhou H.   +6 more
europepmc   +2 more sources

SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma [PDF]

International Journal of Molecular Sciences, 2021
Subepithelial fibrosis is a component of the remodeling observed in the bronchial wall of patients diagnosed with asthma. In this process, human bronchial fibroblasts (HBFs) drive the fibroblast-to-myofibroblast transition (FMT) in response to transforming growth factor-β1 (TGF-β1), which activates the canonical Smad-dependent signaling.
Milena Paw, Dawid Wnuk, Kinga Nit, Sylwia Bobis-Wozowicz, Rafał Szychowski, Alicja Ślusarczyk, Zbigniew Madeja, Marta Michalik   +7 more
openaire   +3 more sources

Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus [PDF]

BioMed Research International, 2014
The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF)αin the hypothalamus of ewes during prolonged inflammation. Inflammation was induced by the administration of lipopolysaccharide (LPS) (400 ng/kg) over 7 days.
Andrzej P. Herman, Agata Krawczyńska, Joanna Bochenek, Hanna Antushevich, Anna Herman, Dorota Tomaszewska-Zaremba   +5 more
openaire   +2 more sources

In vitro modeling of COPD inflammation and limitation of p38 inhibitor - SB203580.

International journal of chronic obstructive pulmonary disease, 2016
Systemic inflammation and steroid resistance are the hallmarks of COPD. We examined the impact of p38 inhibitor (SB203580) in in vitro assays of systemic inflammation using pulmonary cells and patients' sera.Data from 66 COPD patients and 15 age-/sex-matched healthy controls were compared.
Meng, Aihong, Zhang, Xiaopeng, Wu, Siyu, Wu, Mingxia, Li, Jing, Yan, Xixin, Kopec-Harding, Kamilla, Wu, Jiakai   +7 more
openaire   +4 more sources