Results 1 to 10 of about 27,930 (225)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U-87 MG cells. [PDF]

FEBS Open Bio
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Gupta P, Furness SG, Gharbi T, De Paoli-Iseppi R, Joshi SS, Clark M, Hare DL, Wookey P.   +7 more
europepmc   +2 more sources

Cell-Free DNA as a Biomarker of Cell Death and Treatment Response for On-Chip Three-Dimensional Tumor Models. [PDF]

Adv Healthc Mater
This study presents quantifying cell‐free DNA (cfDNA) as a non‐disruptive and rapidly quantifiable method for assessing cell death for on‐chip 3D sarcoma tumor models. On‐chip cfDNA release reflects tumor burden, extent of cell death, and survival of in vitro and ex vivo 3D models, providing valuable insight into the temporal response of tumor models ...
Ziaee M, Lafontaine J, Id Said B, Kamal K, Tsoi K, Rodier F, Gervais T, Wong P.   +7 more
europepmc   +2 more sources

Diethylene Glycol-Linked Ring-Fused Bis-Azoles: Target-Oriented Synthesis, In Silico Screening, and Antitumor Activity. [PDF]

ChemMedChem
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Al-Hussain SA, Alharbi AS, Muhammad ZA, Halim ASA, Zaki MEA, Bagley MC, Kassab RM.   +6 more
europepmc   +2 more sources

Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209

Metabolites, 2022
The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of Streptomyces sp.
You-Ying Chen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Bo-Rong Peng, Yu-Cheng Chen, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Pei-Tzu Yen, Lung-Shuo Wang, Kuei-Hung Lai   +11 more
doaj   +1 more source

Bacteroides fragilis Toxin Induces Cleavage and Proteasome Degradation of E-cadherin in Human Breast Cancer Cell Lines BT-474 and MCF7

Korean Journal of Clinical Laboratory Science, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) has been reported to promote colitis and colon cancer through the secretion of B. fragilis toxin (BFT), a zinc-dependent metalloprotease. In colonic epithelial cells, BFT induces the cleavage of E-cadherin into
Da-Hye KANG, Sang-Hyeon YOO, Ju-Eun HONG, Ki-Jong RHEE   +3 more
doaj   +1 more source

Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380

Frontiers in Microbiology, 2022
Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380.
Tongxu Cui, Simin Lin, Zizhen Wang, Peng Fu, Peng Fu, Cong Wang, Weiming Zhu, Weiming Zhu   +7 more
doaj   +1 more source

Natural Products in Polyclad Flatworms

Marine Drugs, 2021
Marine invertebrates are promising sources of novel bioactive secondary metabolites, and organisms like sponges, ascidians and nudibranchs are characterised by possessing potent defensive chemicals.
Justin M. McNab, Jorge Rodríguez, Peter Karuso, Jane E. Williamson   +3 more
doaj   +1 more source

Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties

MicrobiologyOpen, 2020
Applying a bioactivity‐guided isolation approach, staurosporine was separated and identified as the active principle in the culture extract of the new isolate Streptomyces sp. BV410 collected from the chamomile rhizosphere.
Marija Mojicevic, Paul M. D'Agostino, Aleksandar Pavic, Sandra Vojnovic, Ramsankar Senthamaraikannan, Branka Vasiljevic, Tobias A. M. Gulder, Jasmina Nikodinovic‐Runic   +7 more
doaj   +1 more source

Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway

European Journal of Medical Research, 2019
Background Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled ...
Manuela Malsy, Diane Bitzinger, Bernhard Graf, Anika Bundscherer   +3 more
doaj   +1 more source

Upregulation of Survivin in G2/M Cells and Inhibition of Caspase 9 Activity Enhances Resistance in Staurosporine-Induced Apoptosis

Neoplasia: An International Journal for Oncology Research, 2004
Survivin, a member of the inhibitor of apoptosis (IAP) gene family, plays an important role in both the regulation of cell cycle and the inhibition of apoptosis, and is frequently overexpressed in many tumor types.
Anmol Chandele, Vandna Prasad, Jayashree C. Jagtap, Ravi Shukla, Padma R. Shastry   +4 more
doaj   +1 more source