Results 1 to 10 of about 25,871 (229)
Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties [PDF]
MicrobiologyOpen, 2020 Applying a bioactivity‐guided isolation approach, staurosporine was separated and identified as the active principle in the culture extract of the new isolate Streptomyces sp. BV410 collected from the chamomile rhizosphere.
Marija Mojicevic +7 more
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Potential Inhibitors of Human–Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model [PDF]
Marine DrugsPrimary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri.
Javier Chao-Pellicer +7 more
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Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209
Metabolites, 2022 The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of Streptomyces sp.
You-Ying Chen +11 more
doaj +1 more source
Korean Journal of Clinical Laboratory Science, 2023 Enterotoxigenic Bacteroides fragilis (ETBF) has been reported to promote colitis and colon cancer through the secretion of B. fragilis toxin (BFT), a zinc-dependent metalloprotease. In colonic epithelial cells, BFT induces the cleavage of E-cadherin into
Da-Hye KANG +3 more
doaj +1 more source
Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
Frontiers in Microbiology, 2022 Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380.
Tongxu Cui +7 more
doaj +1 more source
Natural Products in Polyclad Flatworms
Marine Drugs, 2021 Marine invertebrates are promising sources of novel bioactive secondary metabolites, and organisms like sponges, ascidians and nudibranchs are characterised by possessing potent defensive chemicals.
Justin M. McNab +3 more
doaj +1 more source
European Journal of Medical Research, 2019 Background Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled ...
Manuela Malsy +3 more
doaj +1 more source
Marine Drugs, 2012 The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (<strong>1</strong>) and 3-hydroxy-7-oxostaurosporine (<strong>2</strong>), obtained from mid-polar fractions of an ...
Leticia Veras Costa-Lotufo +8 more
doaj +1 more source
FEBS Open Bio, 2021 The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα ...
Lan Li +5 more
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Modulatory Impact of Lamiaceae Metabolites on Apoptosis of Human Leukemia Cells
Frontiers in Pharmacology, 2022 Lamiaceae species are rich sources of biologically active compounds which have been applied in medicine since ancient times. Especially their antineoplastic properties have been thoroughly studied with respect to their putative application in ...
Izabela Berdowska +3 more
doaj +1 more source