Results 21 to 30 of about 25,920 (226)

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
core   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa [PDF]

, 2014
Alterations in the intracellular levels of calcium are a common response to cell death stimuli in animals and fungi and, particularly, in the Neurospora crassa response to staurosporine.
Cordeiro, JM, Correia-de-Sá, Paulo, Videira, Arnaldo, Chiara Lucchi, Gonçalves, A. Pedro; id_orcid, Kowbel, David J., David J. Kowbel, Kowbel, David J, Gonçalves, AP, Daniel J. Rigden, Rigden, Daniel J., A. Pedro Gonçalves, Glass, NL, João Monteiro, N. Louise Glass, Monteiro, João, Lucchi, Chiara, Glass, N. Louise, J. Miguel Cordeiro, Paulo Correia-de-Sá, Rigden, Daniel J, Cordeiro, J. Miguel, Arnaldo Videira   +22 more
core   +1 more source

Hantaviruses inhibit staurosporine-induced apoptosis. [PDF]

, 2013
Endothelial and epithelial cells were infected with hantavirus for three days or left uninfected (control). Cells were then exposed to the apoptosis-inducing drug staurosporine, and subsequently analyzed for induction of apoptosis.
Karin B. Sundström (337165), Nicole D. Tischler (395814), Shawon Gupta (395812), Monika Braun (395813), Jonas Klingström (45509), Malin Stoltz (337164), Niklas K. Björkström (339612), Hans-Gustaf Ljunggren (189410)   +7 more
core   +1 more source

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

mSphere, 2017
Protein kinases are key regulators of signal transduction pathways that participate in diverse cellular processes. In fungal pathogens, kinases regulate signaling pathways that govern drug resistance, stress adaptation, and pathogenesis.
Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen   +4 more
doaj   +1 more source

Rotenone Enhances the Antifungal Properties of Staurosporine [PDF]

Eukaryotic Cell, 2010
ABSTRACT We studied staurosporine-induced cell death in the filamentous fungus Neurospora crassa . The generation of reactive oxygen species during the process appears to be an important signaling event, since addition of the antioxidant glutathione prevents the effects of staurosporine on fungal growth ...
Ana, Castro, Catarina, Lemos, Artur, Falcão, Andreia S, Fernandes, N Louise, Glass, Arnaldo, Videira   +5 more
openaire   +2 more sources

Ambra1 degradation during staurosporine-induced apoptosis. [PDF]

, 2014
A: SW620 cells treated with 1 µM staurosporine. Ambra1, Beclin1, Vps34 and ATG5 expression as well as the appearance of cleaved PARP fragments were analyzed by Western blot at different time points.
Yilin Gu (527867), Liang Wang (23021), Wen Gu (129075), Bin Yi (137660), Songbing He (527868), Qinyi Qian (527865), Daiwei Wan (527864), Zhilong He (527866)   +7 more
core   +1 more source

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition

Biomolecules, 2020
Finding effective neuroprotective strategies to combat various neurodegenerative disorders still remain a clinically unmet need. Methyl caffeate (MC), a naturally occurring ester of caffeic acid, possesses antioxidant and anti-inflammatory activities ...
Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Władysław Lasoń   +4 more
doaj   +1 more source

Staurosporine induces different cell death forms in cultured rat astrocytes [PDF]

, 2012
Background. Astroglial cells are frequently involved in malignant transformation. Besides apoptosis, necroptosis, a different form of regulated cell death, seems to be related with glioblastoma genesis, proliferation, angiogenesis and invasion.
Janez Simenc, Metoda Lipnik-Stangelj, Šimenc, Janez, Lipnik-Štangelj, Metoda   +3 more
core   +2 more sources

Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway

Tumor Biology, 2017
Staurosporine, which is an inhibitor of a broad spectrum of protein kinases, has shown cytotoxicity on several human cancer cells. However, the underlying mechanism is not well understood.
Youming Ding, Bin Wang, Xiaoyan Chen, Yu Zhou, Jianhui Ge   +4 more
doaj   +1 more source