Results 21 to 30 of about 27,930 (225)

Temporal analysis of the autophagic and apoptotic phenotypes in Leishmania parasites

Microbial Cell, 2018
The leishmaniases are worldwide neglected tropical diseases caused by parasitic protozoa of the Leishmania genus. Different stimuli induce Leishmania cell death, but the proteins involved remain poorly understood.
Louise Basmaciyan, Laurence Berry, Julie Gros, Nadine Azas, Magali Casanova   +4 more
doaj   +1 more source

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

mSphere, 2017
Protein kinases are key regulators of signal transduction pathways that participate in diverse cellular processes. In fungal pathogens, kinases regulate signaling pathways that govern drug resistance, stress adaptation, and pathogenesis.
Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen   +4 more
doaj   +1 more source

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition

Biomolecules, 2020
Finding effective neuroprotective strategies to combat various neurodegenerative disorders still remain a clinically unmet need. Methyl caffeate (MC), a naturally occurring ester of caffeic acid, possesses antioxidant and anti-inflammatory activities ...
Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Władysław Lasoń   +4 more
doaj   +1 more source

Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

Marine Drugs, 2012
The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (<strong>1</strong>) and 3-hydroxy-7-oxostaurosporine (<strong>2</strong>), obtained from mid-polar fractions of an ...
Leticia Veras Costa-Lotufo, Norberto Peporine Lopes, Edilberto Rocha Silveira, Tito Monteiro da Cruz Lotufo, Renata Takeara, Manoel Odorico de Moraes, Elthon Gois Ferreira, Diego Veras Wilke, Paula Christine Jimenez   +8 more
doaj   +1 more source

Staurosporine induces different cell death forms in cultured rat astrocytes [PDF]

, 2012
Background. Astroglial cells are frequently involved in malignant transformation. Besides apoptosis, necroptosis, a different form of regulated cell death, seems to be related with glioblastoma genesis, proliferation, angiogenesis and invasion.
Janez Simenc, Metoda Lipnik-Stangelj, Šimenc, Janez, Lipnik-Štangelj, Metoda   +3 more
core   +1 more source

Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells

, 2013
Staurosporine, a non-specific protein kinase inhibitor, has been shown to induce neurite outgrowth in PC12 cells, but the mechanism by which staurosporine induces neurite outgrowth is still obscure.
서정택, 강정완, 배윤수
core   +2 more sources

Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase-3 Activation: A Study With the Kinase Inhibitor Staurosporine

Frontiers in Physiology, 2020
Oxidative stress is known to contribute to the progression of apoptosis. Staurosporine is a broad-spectrum inducer of apoptosis, but its mechanism of action is not well understood. The goal of the present work was to elucidate the role of glutathione and
Aysenur Musaogullari, Alysia Mandato, Yuh-Cherng Chai   +2 more
doaj   +1 more source

Roles of amygdalin and celastrol on staurosporine-treated mesenchymal stem cells in an in vitro culture [PDF]

Herba Polonica
Introduction: Substances of a plant origin have enjoyed widespread use in medicine for ages because they have a beneficial effect on the human body. Amygdalin and celastrol, which are obtained from plants, among others, have proven to have an anti-cancer
Aleksandra Lasia, Paulina Borkowska, Jan Kowalski   +2 more
doaj   +1 more source

Rotenone Enhances the Antifungal Properties of Staurosporine [PDF]

Eukaryotic Cell, 2010
ABSTRACT We studied staurosporine-induced cell death in the filamentous fungus Neurospora crassa . The generation of reactive oxygen species during the process appears to be an important signaling event, since addition of the antioxidant glutathione prevents the effects of staurosporine on fungal growth ...
Ana, Castro, Catarina, Lemos, Artur, Falcão, Andreia S, Fernandes, N Louise, Glass, Arnaldo, Videira   +5 more
openaire   +2 more sources

Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study

BMC Cancer, 2009
Background Lung cancer is one of the most malignant tumors, representing a significant threat to human health. Lung cancer patients often exhibit tumor cell invasion and metastasis before diagnosis which often render current treatments ineffective. Here,
Wang Yanyan, Yang Hongfa, Liu Hongbin, Huang Ji, Song Xingfu   +4 more
doaj   +1 more source