Results 21 to 30 of about 25,871 (229)

Rotenone Enhances the Antifungal Properties of Staurosporine [PDF]

Eukaryotic Cell, 2010
ABSTRACT We studied staurosporine-induced cell death in the filamentous fungus Neurospora crassa . The generation of reactive oxygen species during the process appears to be an important signaling event, since addition of the antioxidant glutathione prevents the effects of staurosporine on fungal growth ...
Ana, Castro, Catarina, Lemos, Artur, Falcão, Andreia S, Fernandes, N Louise, Glass, Arnaldo, Videira   +5 more
openaire   +2 more sources

Roles of amygdalin and celastrol on staurosporine-treated mesenchymal stem cells in an in vitro culture [PDF]

Herba Polonica
Introduction: Substances of a plant origin have enjoyed widespread use in medicine for ages because they have a beneficial effect on the human body. Amygdalin and celastrol, which are obtained from plants, among others, have proven to have an anti-cancer
Aleksandra Lasia, Paulina Borkowska, Jan Kowalski   +2 more
doaj   +1 more source

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition

Biomolecules, 2020
Finding effective neuroprotective strategies to combat various neurodegenerative disorders still remain a clinically unmet need. Methyl caffeate (MC), a naturally occurring ester of caffeic acid, possesses antioxidant and anti-inflammatory activities ...
Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Władysław Lasoń   +4 more
doaj   +1 more source

Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway

Tumor Biology, 2017
Staurosporine, which is an inhibitor of a broad spectrum of protein kinases, has shown cytotoxicity on several human cancer cells. However, the underlying mechanism is not well understood.
Youming Ding, Bin Wang, Xiaoyan Chen, Yu Zhou, Jianhui Ge   +4 more
doaj   +1 more source

Upregulation of Survivin in G2/M Cells and Inhibition of Caspase 9 Activity Enhances Resistance in Staurosporine-Induced Apoptosis

Neoplasia: An International Journal for Oncology Research, 2004
Survivin, a member of the inhibitor of apoptosis (IAP) gene family, plays an important role in both the regulation of cell cycle and the inhibition of apoptosis, and is frequently overexpressed in many tumor types.
Anmol Chandele, Vandna Prasad, Jayashree C. Jagtap, Ravi Shukla, Padma R. Shastry   +4 more
doaj   +1 more source

Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production

, 2022
Aims Sequencing and genome analysis of two co-isolated streptomycetes, named BV410-1 and BV410-10, and the effect of their co-cultivation on the staurosporine production.
Gulder, Tobias A. M., Tobias A. M. Gulder, Stevanović, Milena, Nikodinović-Runić, Jasmina, Vojnović, Sandra, Jasmina Nikodinovic-Runic, Milena Stevanovic, Mojicević, Marija, Marija Mojicevic, D'Agostino, Paul M., Paul M. D'Agostino, Sandra Vojnovic   +11 more
core   +1 more source

Temporal analysis of the autophagic and apoptotic phenotypes in Leishmania parasites

Microbial Cell, 2018
The leishmaniases are worldwide neglected tropical diseases caused by parasitic protozoa of the Leishmania genus. Different stimuli induce Leishmania cell death, but the proteins involved remain poorly understood.
Louise Basmaciyan, Laurence Berry, Julie Gros, Nadine Azas, Magali Casanova   +4 more
doaj   +1 more source

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A

mSphere, 2017
Protein kinases are key regulators of signal transduction pathways that participate in diverse cellular processes. In fungal pathogens, kinases regulate signaling pathways that govern drug resistance, stress adaptation, and pathogenesis.
Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen   +4 more
doaj   +1 more source

Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase-3 Activation: A Study With the Kinase Inhibitor Staurosporine

Frontiers in Physiology, 2020
Oxidative stress is known to contribute to the progression of apoptosis. Staurosporine is a broad-spectrum inducer of apoptosis, but its mechanism of action is not well understood. The goal of the present work was to elucidate the role of glutathione and
Aysenur Musaogullari, Alysia Mandato, Yuh-Cherng Chai   +2 more
doaj   +1 more source

Staurosporine‐induced collapse of cochlear hair bundles [PDF]

Journal of Comparative Neurology, 2014
ABSTRACTEarly postnatal mouse cochlear cultures were treated with a small panel of kinase inhibitors to elucidate the mechanisms underlying the maintenance of hair‐bundle structure in the developing inner ear. At low concentrations (1–10 nM), staurosporine causes the collapse and loss of hair bundles without provoking hair‐cell death, as judged by lack
Goodyear, Richard J, Ratnayaka, Helen SK, Warchol, Mark E, Richardson, Guy P   +3 more
openaire   +2 more sources