Results 31 to 40 of about 25,871 (229)

Cytotoxic roles of apigenin and kaempferol on staurosporine-treated mesenchymal stem cells in an in vitro culture

Herba Polonica, 2021
Flavonoids are widely distributed in the wild. They constitute a large group of compounds that have a beneficial effect on the human body. Apigenin and kaempferol, which belong to the flavone subgroup, have, inter alia, an antitumor effect. The influence
Kosiedowska Magdalena, Burczak Arkadiusz, Morys Julia, Borkowska Paulina, Kowalski Jan   +4 more
doaj   +1 more source

Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study

BMC Cancer, 2009
Background Lung cancer is one of the most malignant tumors, representing a significant threat to human health. Lung cancer patients often exhibit tumor cell invasion and metastasis before diagnosis which often render current treatments ineffective. Here,
Wang Yanyan, Yang Hongfa, Liu Hongbin, Huang Ji, Song Xingfu   +4 more
doaj   +1 more source

Cytoprotective roles of epigallocatechin gallate and resveratrol on staurosporine-treated mesenchymal stem cells in in vitro culture

Herba Polonica, 2021
Introduction: There are many scientific reports on the beneficial effects of epigallocatechin gallate and resveratrol on the human body, e.g. antioxidant properties, a protective effect on the circulatory system and reduction of inflammation.
Burczak Arkadiusz, Kosiedowska Magdalena, Borkowska Paulina, Kowalski Jan   +3 more
doaj   +1 more source

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
core   +1 more source

Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes

Frontiers in Cell and Developmental Biology, 2022
In a variety of physiological and pathophysiological conditions, cells are exposed to acidic environments. Severe synovial fluid acidification also occurs in a progressive state of osteoarthritis (OA) affecting articular chondrocytes.
Michael Kittl, Michael Kittl, Martina Winklmayr, Martina Winklmayr, Julia Preishuber-Pflügl, Julia Preishuber-Pflügl, Victoria Strobl, Victoria Strobl, Martin Gaisberger, Martin Gaisberger, Martin Gaisberger, Markus Ritter, Markus Ritter, Markus Ritter, Markus Ritter, Martin Jakab, Martin Jakab   +16 more
doaj   +1 more source

Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges

Marine Drugs, 2010
Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp.
Heidrun Moll, Ute Hentschel, Chris M. Ireland, Tim S. Bugni, Svitlana Kozytska, Sheila Marie Pimentel-Elardo   +5 more
doaj   +1 more source

Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa

, 2014
Alterations in the intracellular levels of calcium are a common response to cell death stimuli in animals and fungi and, particularly, in the Neurospora crassa response to staurosporine.
Cordeiro, JM, Correia-de-Sá, Paulo, Videira, Arnaldo, Chiara Lucchi, Gonçalves, A. Pedro; id_orcid, Kowbel, David J., David J. Kowbel, Kowbel, David J, Gonçalves, AP, Daniel J. Rigden, Rigden, Daniel J., A. Pedro Gonçalves, Glass, NL, João Monteiro, N. Louise Glass, Monteiro, João, Lucchi, Chiara, Glass, N. Louise, J. Miguel Cordeiro, Paulo Correia-de-Sá, Rigden, Daniel J, Cordeiro, J. Miguel, Arnaldo Videira   +22 more
core   +1 more source

Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures

Marine Drugs, 2019
Indolocarbazoles are a family of natural alkaloids characterized by their potent protein kinase and topoisomerase I inhibitory activity. Among them, staurosporine (1) has exhibited promising inhibitory activity against parasites. Based on new insights on
Luis Cartuche, María Reyes-Batlle, Ines Sifaoui, Iñigo Arberas-Jiménez, José E. Piñero, José J. Fernández, Jacob Lorenzo-Morales, Ana R. Díaz-Marrero   +7 more
doaj   +1 more source

Hantaviruses inhibit staurosporine-induced apoptosis.

, 2013
Endothelial and epithelial cells were infected with hantavirus for three days or left uninfected (control). Cells were then exposed to the apoptosis-inducing drug staurosporine, and subsequently analyzed for induction of apoptosis.
Karin B. Sundström (337165), Nicole D. Tischler (395814), Shawon Gupta (395812), Monika Braun (395813), Jonas Klingström (45509), Malin Stoltz (337164), Niklas K. Björkström (339612), Hans-Gustaf Ljunggren (189410)   +7 more
core   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source