Results 31 to 40 of about 25,920 (226)
Synergism between staurosporine and drugs inducing endoplasmic reticulum stress [PDF]
, 2006 Drugs causing endoplasmic reticulum or mitochondrial dysfunction may trigger apoptosis in eukaryotic cells. The thiol reagent dithiothreitol (DTT) belongs to the first group whereas the protein kinases inhibitor staurosporine acts on mitochondria.
TREVISI, LUCIA +7 more
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Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion. [PDF]
, 1990 In intact sheep gonadotropes, the protein kinase inhibitor, staurosporine, inhibited the stimulatory effect of phorbol 12-myristate 13-acetate (PMA) on luteinizing hormone (LH) secretion.
Wakeneld, Ian K. +14 more
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BMC Cancer, 2009 Background Lung cancer is one of the most malignant tumors, representing a significant threat to human health. Lung cancer patients often exhibit tumor cell invasion and metastasis before diagnosis which often render current treatments ineffective. Here,
Wang Yanyan +4 more
doaj +1 more source
Competitive ABPP identifies PknB, D, and F as staurosporine targets. [PDF]
, 2014 (A) Structure of the ATP activity-based probe. (B) Grey scale image of Mtb lysate fluorescently labeled following ABPP. Detergent-solubilized Mtb proteome was treated with staurosporine at 25-fold molar excess over ATP-ABP before labeling with ATP-ABP at
Lindsey N. Anderson (506469) +7 more
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Marine Drugs, 2012 The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (<strong>1</strong>) and 3-hydroxy-7-oxostaurosporine (<strong>2</strong>), obtained from mid-polar fractions of an ...
Leticia Veras Costa-Lotufo +8 more
doaj +1 more source
Frontiers in Physiology, 2020 Oxidative stress is known to contribute to the progression of apoptosis. Staurosporine is a broad-spectrum inducer of apoptosis, but its mechanism of action is not well understood. The goal of the present work was to elucidate the role of glutathione and
Aysenur Musaogullari +2 more
doaj +1 more source
State-dependent inhibition by staurosporine and K-252c. [PDF]
, 2013 (A) The molecular structures for staurosporine (left) and staurosporine aglycone, K-252c (right). (B) Cellular PKC responses with (closed circles) or without (open circles) 100 nM staurosporine (ST). Application of 3 µM oxo-M (black box) is indicated. (C)
Ida M. Smith (341818) +1 more
core +1 more source
Staurosporine‐induced collapse of cochlear hair bundles [PDF]
Journal of Comparative Neurology, 2014 ABSTRACTEarly postnatal mouse cochlear cultures were treated with a small panel of kinase inhibitors to elucidate the mechanisms underlying the maintenance of hair‐bundle structure in the developing inner ear. At low concentrations (1–10 nM), staurosporine causes the collapse and loss of hair bundles without provoking hair‐cell death, as judged by lack
Goodyear, Richard J +3 more
openaire +2 more sources
Regulation of PDGFR-α in rat pulmonary myofibroblasts by staurosporine [PDF]
, 2001 Upregulation of the platelet-derived growth factor (PDGF) receptor-α (PDGFR-α) is a mechanism of myofibroblast hyperplasia during pulmonary fibrosis.
James C. Bonner +3 more
core +1 more source
Roles of amygdalin and celastrol on staurosporine-treated mesenchymal stem cells in an in vitro culture [PDF]
Herba PolonicaIntroduction: Substances of a plant origin have enjoyed widespread use in medicine for ages because they have a beneficial effect on the human body. Amygdalin and celastrol, which are obtained from plants, among others, have proven to have an anti-cancer
Aleksandra Lasia +2 more
doaj +1 more source