Results 31 to 40 of about 27,930 (225)
Frontiers in Cell and Developmental Biology, 2022 In a variety of physiological and pathophysiological conditions, cells are exposed to acidic environments. Severe synovial fluid acidification also occurs in a progressive state of osteoarthritis (OA) affecting articular chondrocytes.
Michael Kittl +16 more
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Herba Polonica, 2021 Flavonoids are widely distributed in the wild. They constitute a large group of compounds that have a beneficial effect on the human body. Apigenin and kaempferol, which belong to the flavone subgroup, have, inter alia, an antitumor effect. The influence
Kosiedowska Magdalena +4 more
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Herba Polonica, 2021 Introduction: There are many scientific reports on the beneficial effects of epigallocatechin gallate and resveratrol on the human body, e.g. antioxidant properties, a protective effect on the circulatory system and reduction of inflammation.
Burczak Arkadiusz +3 more
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Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
Marine Drugs, 2010 Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp.
Heidrun Moll +5 more
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Hantaviruses inhibit staurosporine-induced apoptosis.
, 2013 Endothelial and epithelial cells were infected with hantavirus for three days or left uninfected (control). Cells were then exposed to the apoptosis-inducing drug staurosporine, and subsequently analyzed for induction of apoptosis.
Karin B. Sundström (337165) +7 more
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Staurosporine‐induced collapse of cochlear hair bundles [PDF]
Journal of Comparative Neurology, 2014 ABSTRACTEarly postnatal mouse cochlear cultures were treated with a small panel of kinase inhibitors to elucidate the mechanisms underlying the maintenance of hair‐bundle structure in the developing inner ear. At low concentrations (1–10 nM), staurosporine causes the collapse and loss of hair bundles without provoking hair‐cell death, as judged by lack
Goodyear, Richard J +3 more
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Antiamoebic Activities of Indolocarbazole Metabolites Isolated from Streptomyces sanyensis Cultures
Marine Drugs, 2019 Indolocarbazoles are a family of natural alkaloids characterized by their potent protein kinase and topoisomerase I inhibitory activity. Among them, staurosporine (1) has exhibited promising inhibitory activity against parasites. Based on new insights on
Luis Cartuche +7 more
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Microorganisms, 2020 Naegleria fowleri is an opportunistic pathogenic free-living amoeba which is able to rapidly colonize the central nervous system (CNS) and causes a lethal infection known as primary amoebic meningoencephalitis (PAM).
Aitor Rizo-Liendo +8 more
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Staurosporine as an Antifungal Agent
International Journal of Molecular SciencesStaurosporine (STS) was discovered in 1977 by Omura and colleagues during a chemical screening for microbial alkaloids. It was the first indolocarbazole compound isolated from a soil-dwelling bacterium, Streptomyces staurosporeus. STS was also found to have antifungal activity, but its potent protein kinase (PK) inhibitory properties, perhaps the most ...
Filipa C. Santos +3 more
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Ambra1 degradation during staurosporine-induced apoptosis.
, 2014 A: SW620 cells treated with 1 µM staurosporine. Ambra1, Beclin1, Vps34 and ATG5 expression as well as the appearance of cleaved PARP fragments were analyzed by Western blot at different time points.
Yilin Gu (527867) +7 more
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