Results 51 to 60 of about 25,871 (229)

Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion.

, 1990
In intact sheep gonadotropes, the protein kinase inhibitor, staurosporine, inhibited the stimulatory effect of phorbol 12-myristate 13-acetate (PMA) on luteinizing hormone (LH) secretion.
Wakeneld, Ian K., Macrae, M.Bruce, James S. Davidson, van der Merwe, P.Anton, Davidson, JS, Millar, Robert P., Davidson, James S., Robert P. Millar, Wakefield, IK, M.Bruce Macrae, Van Der Merwe, Philip, Millar, RP, P.Anton van der Merwe, Macrae, MB, Ian K. Wakeneld   +14 more
core   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Competitive ABPP identifies PknB, D, and F as staurosporine targets.

, 2014
(A) Structure of the ATP activity-based probe. (B) Grey scale image of Mtb lysate fluorescently labeled following ABPP. Detergent-solubilized Mtb proteome was treated with staurosporine at 25-fold molar excess over ATP-ABP before labeling with ATP-ABP at
Lindsey N. Anderson (506469), Reiling Liao (42999), Tige Rustad (324569), Aaron T. Wright (125925), Anja R. Ollodart (506470), Christoph Grundner (506471), Corrie Ortega (488328), David R. Sherman (43000)   +7 more
core   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy

eLife, 2014
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and ...
Alexander A Warkentin, Michael S Lopez, Elisabeth A Lasater, Kimberly Lin, Bai-Liang He, Anskar YH Leung, Catherine C Smith, Neil P Shah, Kevan M Shokat   +8 more
doaj   +1 more source

State-dependent inhibition by staurosporine and K-252c.

, 2013
(A) The molecular structures for staurosporine (left) and staurosporine aglycone, K-252c (right). (B) Cellular PKC responses with (closed circles) or without (open circles) 100 nM staurosporine (ST). Application of 3 µM oxo-M (black box) is indicated. (C)
Ida M. Smith (341818), Naoto Hoshi (341820)   +1 more
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Optimization of Fermentation and Mutagenesis for Enhanced Staurosporine Production in the Marine-Derived Streptomyces Strain OUCMDZ-3118

Fermentation
Background: Staurosporine is a potent broad-spectrum alkaloid antibiotic originally isolated from Streptomyces sp. It is renowned for its strong inhibitory activity against protein kinases by competitively binding to their ATP-binding sites.
Mingxing Zuo, Jiuman Xiang, Mingshen Zhang, Weiming Zhu, Liping Wang   +4 more
doaj   +1 more source

Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for Liposomal Loading of Poorly Water-Soluble Compounds

Pharmaceutics, 2019
A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery. These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading capacity and ...
Griffin Pauli, Wei-Lun Tang, Shyh-Dar Li
doaj   +1 more source

Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines. [PDF]

PLoS ONE, 2013
Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line.
Federico Tagliati, Teresa Gagliano, Erica Gentilin, Mariella Minoia, Daniela Molè, Ettore C Delgi Uberti, Maria Chiara Zatelli   +6 more
doaj   +1 more source