Results 71 to 80 of about 25,871 (229)

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Staurosporine blocks evoked release of FM1-43 but not acetylcholine from frog motor nerve terminals

, 1995
The protein kinase inhibitor staurosporine inhibited, and often abolished, activity-dependent destaining of frog motor nerve terminals that had been preloaded with the fluorescent dye FM1-43.
WJ Betz, AW Henkel
core   +1 more source

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

Staurosporine-producing Streptomyces sp. strain 11 × 1 cell-free culture filtrates control diseases caused by the oomycete plant pathogens Pythium myriotylum and Phytophthora sojae

Oomycetes are devastating soil-borne plant pathogens, and cause numerous losses on diverse crops worldwide. In this study, our aim was to identify actinomycetes with antimicrobial activity towards oomycetes from the rhizosphere of soybean.
Lihui Wei (511898), Dongmei Zhou (786550), Jingjing Li (7654), Qimeng Zhang (3390125), Xiaoyu Wang (182979), Hao Peng (231482), Yifan Chen (446592), Jinfeng Zhang (22473), Hongli Zhu (1419181), Paul Daly (3725233), Wilfred Mabeche Anjago (17773133), Xian Wen (11714101), Deyu Zhuo (17773130), Lunji Wang (17773127), Min Jiu (67935)   +14 more
core   +1 more source

Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes

, 1994
K-Cl cotransport can participate in volume regulation in a number of cell types. Swelling activation of K-Cl cotransport in sheep erythrocytes proceeds by a two-step process, A<-->B<-->C (Dunham et al., J. Gen. Physiol.
P. B. Dunham, I. Bize
core   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

Computational POM and DFT Evaluation of Experimental in-vitro Cancer Inhibition of Staurosporine-Ruthenium(II) Complexes: The Power Force of Organometallics in Drug Design

Acta Chimica Slovenica, 2015
A computational Petra/Osiris/Molinspiration/DFT(POM/DFT) based model has been developed for the identification of physic-chemical parameters governing the bioactivity of  Ruthenium-Staurosporine complexes 2-4 containing an antitumoral-Kinase (TK ...
Taibi Ben Hadda, Zuhal Karagoz Genc, Vijay H. Masand, Nadia Nebbache, Ismail Warad, Shehdeh Jodeh, Murat Genc, Yahia N. Mabkhot, Assem Barakat, Hector Salgado Zamora   +9 more
doaj   +1 more source

Total Synthesis of (+)-RK-286c, (+)-MLR-52, (+)-Staurosporine, and (+)-K252a

, 2016
Total Synthesis of (+)-RK-286c, (+)-MLR-52, (+)-Staurosporine, and ...
Brian M. Stoltz (1297560), Steven N. Goodman (259061), John L. Wood (1407307)   +2 more
core   +1 more source

S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Fibrotic stimuli induce S100A4 expression, promoting the activation of apoptosis‐resistant fibroblasts through engagement of ERK‐associated signaling. In fibroblasts, S100A4 orchestrates fibroblast fate by enhancing migration, promoting stress fiber formation, increasing ECM contractility, upregulating α‐SMA expression, and supporting survival ...
Spring Li, Banruo Cai, Xu Zhang, Guoqiang Cai, Yong Zhou, Brant M. Wagener, Qiang Ding   +6 more
wiley   +1 more source

Staurosporine and ent-Staurosporine:  The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles¹

, 2016
The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo ...
Samuel J. Danishefsky (1265454), Michel Gallant (2718070), Lawrence M. Ballas (2994972), T. C. Chou (2994969), J. T. Link (2510419), Subharekha Raghavan (2309644)   +5 more
core   +2 more sources