Results 71 to 80 of about 25,920 (226)
Staurosporine but not chelerythrine inhibits regeneration in hippocampal organotypic cultures [PDF]
, 1997 A mechanical lesion in hippocampal organotypic cultures is followed by a recovery process involving scar formation, sprouting of fibres and formation of new functional synapses.
Toni, Nicolas +2 more
core +1 more source
Pharmaceutics, 2019 A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery. These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading capacity and ...
Griffin Pauli, Wei-Lun Tang, Shyh-Dar Li
doaj +1 more source
Combinations of 5‐Fluorouracil with UCN‐01 or Staurosporine
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Sigmond, J. +3 more
openaire +3 more sources
Induction of Suicidal Erythrocyte Death by Cantharidin
Toxins, 2015 The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells,
Kousi Alzoubi +5 more
doaj +1 more source
BMEMat, EarlyView.Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang +13 more
wiley +1 more source
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
PLoS ONE, 2020 The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang +6 more
doaj +1 more source
Synthesis and Antitumor Activity of Staurosporine Derivatives
Natural Product Communications, 2022 Twenty-four derivatives of staurosporine were synthesized by modification at the 3′- N , 3- and 7-positions. Of these compounds, 16 were synthesized for the first time and their structures were determined by NMR spectroscopy, ECD, and HRESIMS.
Gang Li +6 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley +1 more source
On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine [PDF]
, 2009 Protein kinases are important regulatory enzymes in signal transduction and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases.
William R. Pitt +3 more
core +2 more sources
Marine DrugsPrimary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri.
Javier Chao-Pellicer +7 more
doaj +1 more source