Results 61 to 70 of about 25,871 (229)
Txnip expression promotes JNK-mediated neuronal death in response to reactive oxygen species
Frontiers in Molecular Neuroscience, 2023 TXNIP is a protein sensitive to oxidant conditions whose expression is related to the progression of death in cancer, diabetes, ischemia, and neurodegenerative diseases, among others. Because of this, many studies propose TXNIP as a therapeutic target in
Brenda García-Hernández, Julio Morán
doaj +1 more source
Regulation of PDGFR-α in rat pulmonary myofibroblasts by staurosporine
, 2001 Upregulation of the platelet-derived growth factor (PDGF) receptor-α (PDGFR-α) is a mechanism of myofibroblast hyperplasia during pulmonary fibrosis.
James C. Bonner +3 more
core +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Combinations of 5‐Fluorouracil with UCN‐01 or Staurosporine
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Sigmond, J. +3 more
openaire +3 more sources
International Endodontic Journal, EarlyView.ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source
Induction of Suicidal Erythrocyte Death by Cantharidin
Toxins, 2015 The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells,
Kousi Alzoubi +5 more
doaj +1 more source
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.
PLoS ONE, 2020 The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang +6 more
doaj +1 more source
Synthesis and Antitumor Activity of Staurosporine Derivatives
Natural Product Communications, 2022 Twenty-four derivatives of staurosporine were synthesized by modification at the 3′- N , 3- and 7-positions. Of these compounds, 16 were synthesized for the first time and their structures were determined by NMR spectroscopy, ECD, and HRESIMS.
Gang Li +6 more
doaj +1 more source
Staurosporine stimulates phospholipase D activation in human polymorphonuclear leukocytes
, 1993 Treatment of 1-O-[3H]alkyl-2-acyl-phosphatidylcholine-prelabeled human polymorphonuclear leukocytes (PMNs) with Staurosporine (50 nM to 1 μM) induced a time- and concentration-dependent generation of tritiated phosphatidic acid (PA), reaching ...
Périanin, Axel +9 more
core +1 more source