Results 61 to 70 of about 27,930 (225)

Induction of Suicidal Erythrocyte Death by Cantharidin

Toxins, 2015
The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells,
Kousi Alzoubi, Jasmin Egler, Marilena Briglia, Antonella Fazio, Caterina Faggio, Florian Lang   +5 more
doaj   +1 more source

Txnip expression promotes JNK-mediated neuronal death in response to reactive oxygen species

Frontiers in Molecular Neuroscience, 2023
TXNIP is a protein sensitive to oxidant conditions whose expression is related to the progression of death in cancer, diabetes, ischemia, and neurodegenerative diseases, among others. Because of this, many studies propose TXNIP as a therapeutic target in
Brenda García-Hernández, Julio Morán
doaj   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Competitive ABPP identifies PknB, D, and F as staurosporine targets.

, 2014
(A) Structure of the ATP activity-based probe. (B) Grey scale image of Mtb lysate fluorescently labeled following ABPP. Detergent-solubilized Mtb proteome was treated with staurosporine at 25-fold molar excess over ATP-ABP before labeling with ATP-ABP at
Lindsey N. Anderson (506469), Reiling Liao (42999), Tige Rustad (324569), Aaron T. Wright (125925), Anja R. Ollodart (506470), Christoph Grundner (506471), Corrie Ortega (488328), David R. Sherman (43000)   +7 more
core   +1 more source

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

PLoS ONE, 2020
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (
Jinwei Zhang, Antje Cordshagen, Igor Medina, Hans Gerd Nothwang, Jacek R Wisniewski, Michael Winklhofer, Anna-Maria Hartmann   +6 more
doaj   +1 more source

Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumours

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Companion canines need advances in therapeutic options for solid tumour malignancies. Natural killer (NK) cell infusions offer a promising treatment modality in canines with solid tumours. Autologous natural killer products are limited by dysfunctional immunity and a manufacturing process that delays care whereas allogeneic NK cells offer the ...
Allison M. Weisnicht, Fernanda Szewc, Monica Moonkyung Cho, Han‐Yun Hannah Cheng, Swetha Ganesh, Lauren Mahoney, Kathryn Fox, Portia R. Smith, Mallery Olsen, Rebecca M. Richards, David M. Vail, Christian M. Capitini   +11 more
wiley   +1 more source

Staurosporine and ent-Staurosporine:  The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles¹

, 2016
The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo ...
Samuel J. Danishefsky (1265454), Michel Gallant (2718070), Lawrence M. Ballas (2994972), T. C. Chou (2994969), J. T. Link (2510419), Subharekha Raghavan (2309644)   +5 more
core   +2 more sources

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4782-4798, December 2026.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

, 2004
International audienceTopoisomerase I (Top1), an abundant nuclear enzyme expressed throughout the cell cycle, relaxes DNA supercoiling by forming transient covalent DNA cleavage complexes.
Urasaki, Yoshimasa, Plo, Isabelle, Kohlhagen, Glenda, Saparbaev, Murat, Sordet, Olivier, Laval, Jacques, Pommier, Yves, Pourquier, Philippe, Yoshida, Akira, Antony, Smitha, Solary, Eric, Khan, Qasim   +11 more
core   +1 more source

Potential Inhibitors of Human–Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model

Marine Drugs
Primary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri.
Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Ines Sifaoui, Ana R. Díaz-Marrero, José J. Fernández, Melissa Jamerson, José E. Piñero, Jacob Lorenzo-Morales   +7 more
doaj   +1 more source