Results 81 to 90 of about 25,920 (226)
Thermodynamic characterisation of covalent ligand binding
British Journal of Pharmacology, EarlyView.Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman +4 more
wiley +1 more source
Simple screening method for staurosporine in bacterial cultures using liquid chromatography-tandem mass spectrometry [PDF]
, 2009 Staurosporine has been shown to possess an array of important biological properties such as anti-fungal, anti-bacterial, antihypertensive and anti-cancer.
Hewavitharana, A. +3 more
core +1 more source
CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis
Cell Proliferation, EarlyView.CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng +12 more
wiley +1 more source
Release of a leukocyte activation inhibitor by staurosporine-treated pulmonary artery endothelial cells [PDF]
, 1998 Bovine pulmonary arterial endothelial cells (BPAE) treated with the protein kinase C (PKC) inhibitor staurosporine inhibited[Formula: see text] generation by neutrophils exposed to phorbol myristate acetate (PMA) but did not affect[Formula: see text ...
Xilin Chen, John D. Catravas
core +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Staurosporine mobilizes Ca2+ from secretory granules by inhibiting protein kinase C in rat submandibular acinar cells [PDF]
, 2002 Staurosporine was previously shown to mobilize Ca2+ from the thapsigargin-insensitive Ca2+ store in rat submandibular acinar cells. However, the nature of the store is not yet known.
신동민, 이승일, 서정택
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Lentiviral vector (LVV)-mediated transduction of human CD34+ hematopoietic stem and progenitor cells (HSPCs) holds tremendous promise for the treatment of monogenic hematological diseases.
Gretchen Lewis +10 more
doaj +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source
Staurosporine overrides checkpoints for mitotic onset in BHK cells. [PDF]
, 1992 Under normal conditions, mammalian cells will not initiate mitosis in the presence of either unreplicated or damaged DNA. We report here that staurosporine, a tumor promoter and potent protein kinase inhibitor, can uncouple mitosis from the completion of
Tam, S. W., Schlegel, R.
core
Activation of GSK3 Prevents Termination of TNF-Induced Signaling
Journal of Inflammation Research, 2021 Bastian Welz,* Rolf Bikker,* Leonie Hoffmeister, Mareike Diekmann, Martin Christmann, Korbinian Brand,* René Huber* Institute of Clinical Chemistry, Hannover Medical School, Hannover, 30625, Germany*These authors contributed equally to this ...
Welz B +6 more
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