Results 101 to 110 of about 25,920 (226)

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine [PDF]

, 1993
Tumor necrosis factor (TNF), first described as a cytokine with tumor-necrotizing activity, is now known to be a pleiotropic molecule. The molecular mechanisms responsible for the cytotoxic activity of TNF on malignant cells are still largely unknown. In
Vanhaesebroeck, Bart, Schulze-Osthoff, Klaus, Fiers, Walter, De Valck, Dirk, Heyninck, Karen, Boone, Elke, Van Roy, Frans, Beyaert, Rudi, Haegeman, Guy   +8 more
core  

Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling [PDF]

, 2011
An analysis of the time-dependent genetic response to the death-inducer staurosporine was performed in Neurospora crassa by transcriptional profiling.
Ana Castro, Videira, A., Castro, A., Rui Gardner, Telma A. Lopes, Gardner, R., A. Pedro Gonçalves, N. Louise Glass, Lopes, T. A., Glass, N. L., Andreia S. Fernandes, Fernandes, A. S., Gonçalves, A. P.; id_orcid, Arnaldo Videira   +13 more
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Staurosporine-Induced Cleavage of α-Smooth Muscle Actin During Myofibroblast Apoptosis [PDF]

, 2002
To examine the possibility that staurosporine is applicable for the treatment of abnormal scar formation such as hypertrophic scar and keloid, the cellular process during staurosporine-induced apoptosis was analyzed in myofibroblasts isolated from a rat ...
Toshiyuki Sasaguri, Takahashi-Yanaga, Fumi, Ayako Nakazono-Kusaba, Morimoto, Sachio, Fumi Takahashi-Yanaga, Sasaguri, Toshiyuki, Sachio Morimoto, Masutaka Furue, Nakazono-Kusaba, Ayako, Furue, Masutaka   +9 more
core   +1 more source

Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model

Marine Drugs
Acanthamoeba is a ubiquitous genus of amoebae that can trigger a severe and progressive ocular disease known as Acanthamoeba Keratitis (AK). Furthermore, current treatment protocols are based on the combination of different compounds that are not fully ...
Rubén L. Rodríguez-Expósito, Ines Sifaoui, Lizbeth Salazar-Villatoro, Carlos J. Bethencourt-Estrella, José J. Fernández, Ana R. Díaz-Marrero, Robert Sutak, Maritza Omaña-Molina, José E. Piñero, Jacob Lorenzo-Morales   +9 more
doaj   +1 more source

Staurosporine induces de novo synthesis of prostaglandin H synthase-2 in rat alveolar macrophages. [PDF]

, 1995
This study was initiated to investigate the possible involvement of prostaglandin H synthase in the staurosporine-induced prostaglandin production. The time course of prostaglandin H synthase activity in macrophages treated with staurosporine (20 nM ...
Moon, CH, Lee, SH, Kim, MJ, Kim, JY, Moon, CK, Lee, JY   +5 more
core  

Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC [PDF]

, 1993
The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes δ and ε.
Shigeo Ohno, Tamaoki, Tatsuya, Koichi Suzuki, Ohno, Shigeo, Keiko Mizuno, Mizuno, Keiko, Takaomi C. Saido, Saido, Takaomi C., Suzuki, Koichi, Tatsuya Tamaoki   +9 more
core   +1 more source

Protein kinase-independent inhibition of muscarinic K+ channels by staurosporine [PDF]

, 1994
Acetylcholine (ACh) binding to atrial muscarinic receptors activates an inwardly rectifying K+ current (IK[ACh]) via a pertussis toxin-sensitive GTP-binding protein (GK).
G. E. Breitwieser, C. F. Lo
core   +1 more source

Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockade

Neurobiology of Disease, 2004
The relationship between intracellular Ca2+ ([Ca2+]i) regulation and programmed cell death is not well-defined; both increases and decreases in [Ca2+]i have been observed in cells undergoing apoptosis.
Lorella M.T Canzoniero, Debra J Babcock, Frank J Gottron, Margaret C Grabb, Pat Manzerra, B.Joy Snider, Dennis W Choi   +6 more
doaj   +1 more source

Biosynthetic studies of staurosporine and metabolism studies of Streptomyces staurosporeus. [PDF]

, 1997
Biosynthetic studies of staurosporine and metabolism studies of Streptomyces ...
Shu-Wei. Yang (7958228)
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