Results 111 to 120 of about 25,871 (229)

Aptamer-Mediated Dual-Loaded Liposomal Nanosystem for Synergistic Therapy in Hepatocellular Carcinoma via mTOR/HIF-1α/VEGF Pathway

open access: yesInternational Journal of Nanomedicine
Aiqiu Wei,1,* Ziyi Zhong,1,* Yiming Zhang,1 Jincheng He,1 Haihe Pang,2 Xinhua Xia,1 Xiaoqing Zhang1 1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Hunan Kelun Pharmaceutical Co ...
Wei A   +6 more
doaj  

Effects of staurosporine on protein kinase C and amylase secretion from pancreatic acini

open access: yes, 1989
The effects of staurosporine, a recently isolated microbial alkaloid, on amylase secretion and protein kinase C activity of guinea pig pancreatic acini were investigated.
T. B. Verme   +3 more
core   +1 more source

Effect of TCERG1 knockdown on the staurosporine-induced apoptotic pathway.

open access: yes, 2015
(A) Effect of staurosporine treatment on Jurkat cells. Flow cytometry analysis of Jurkat cells stained with PI without (black) or with the addition of 0.25 (red) or 0.5 μM staurosporine (blue) for 1 h.
Carlos Suñé (812755)   +9 more
core   +1 more source

Neuroprotection against staurosporine by metalloporphyrins independent of antioxidant capability

open access: yes, 2009
Metalloporphyrin catalytic antioxidants are remarkably useful in protecting cells and tissues in a wide array of disease models, attributed primarily to functioning as superoxide dismutase (SOD) mimetics or by scavenging other reactive oxygen species ...
Tauskela, Joseph S., Brunette, Eric
core   +1 more source

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

open access: yes, 1993
Tumor necrosis factor (TNF), first described as a cytokine with tumor-necrotizing activity, is now known to be a pleiotropic molecule. The molecular mechanisms responsible for the cytotoxic activity of TNF on malignant cells are still largely unknown. In
Vanhaesebroeck, Bart   +8 more
core  

Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling

open access: yes, 2011
An analysis of the time-dependent genetic response to the death-inducer staurosporine was performed in Neurospora crassa by transcriptional profiling.
Ana Castro   +13 more
core   +1 more source

Staurosporine-Induced Cleavage of α-Smooth Muscle Actin During Myofibroblast Apoptosis

open access: yes, 2002
To examine the possibility that staurosporine is applicable for the treatment of abnormal scar formation such as hypertrophic scar and keloid, the cellular process during staurosporine-induced apoptosis was analyzed in myofibroblasts isolated from a rat ...
Toshiyuki Sasaguri   +9 more
core   +1 more source

Staurosporine induces de novo synthesis of prostaglandin H synthase-2 in rat alveolar macrophages.

open access: yes, 1995
This study was initiated to investigate the possible involvement of prostaglandin H synthase in the staurosporine-induced prostaglandin production. The time course of prostaglandin H synthase activity in macrophages treated with staurosporine (20 nM ...
Moon, CH   +5 more
core  

Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC

open access: yes, 1993
The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes δ and ε.
Shigeo Ohno   +9 more
core   +1 more source

Protein kinase-independent inhibition of muscarinic K+ channels by staurosporine

open access: yes, 1994
Acetylcholine (ACh) binding to atrial muscarinic receptors activates an inwardly rectifying K+ current (IK[ACh]) via a pertussis toxin-sensitive GTP-binding protein (GK).
G. E. Breitwieser, C. F. Lo
core   +1 more source

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