Results 111 to 120 of about 25,920 (226)

Staurosporine-induced Ca2+ mobilization in rat mandibular salivary acini [PDF]

, 1998
The effect of the protein kinase C inhibitor, staurosporine, on intracellular Ca2+ homeostasis was investigated in rat mandibular salivary acinar cells loaded with fura-2.
신동민, 서정택
core  

Staurosporine Inhibits Frequency-Dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae

Biochemistry Research International, 2012
Myofilament calcium sensitivity decreases with frequency in intact healthy rabbit trabeculae and associates with Troponin I and Myosin light chain-2 phosphorylation.
Kenneth D. Varian, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis, Paul M. L. Janssen   +4 more
doaj   +1 more source

The effect of an HIV-1 viral protease inhibitor on staurosporine-induced apoptosis in immortalized mesangial cells

São Paulo Medical Journal, 2002
CONTEXT: Progressive glomerular sclerosis is a condition characterized by the accumulation of glomerular extracellular matrix and a decrease in the number of glomerular cells.
Adrian Pierce Serone, Simone Mafalda Rodrigues Camargo, Nestor Schor   +2 more
doaj   +1 more source

Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes [PDF]

, 2015
In the present study, we investigated the effect of staurosporine on the formation of cellular processes in human gingival fibroblasts and rat astrocytes.
서정택, 강정완, 문성아
core   +1 more source

Aptamer-Mediated Dual-Loaded Liposomal Nanosystem for Synergistic Therapy in Hepatocellular Carcinoma via mTOR/HIF-1α/VEGF Pathway

International Journal of Nanomedicine
Aiqiu Wei,1,* Ziyi Zhong,1,* Yiming Zhang,1 Jincheng He,1 Haihe Pang,2 Xinhua Xia,1 Xiaoqing Zhang1 1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Hunan Kelun Pharmaceutical Co ...
Wei A, Zhong Z, Zhang Y, He J, Pang H, Xia X, Zhang X   +6 more
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Effect of Staurosporine on the Intracellular Localization of Hepatitis B Virus Core Protein

Indonesian Journal of Biotechnology, 2015
protein is also including in the HBV genome targeting into the nucleus through modulating carboxyl residues byphosphorylation. Nuclear localication Signal (NLS) in HBV core protein is inside the virion structure and it must beunmasked in order to ...
Aris Haryanto, Nastiti Wijayanti, Michael Kann   +2 more
doaj  

Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi

Revista do Instituto de Medicina Tropical de São Paulo, 2012
Trypanosoma evansi is a blood protozoan parasite of the genus Trypanosoma which is responsible for surra (Trypanosomosis) in domestic and wild animals. This study addressed apoptotic-like features in Trypanosoma evansi in vitro. The mechanism of parasite
Gustavo Bruges, Meyerling Betancourt, Mariana March, Evangelina Sanchez, Alfredo Mijares   +4 more
doaj   +1 more source

Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements.

PLoS ONE, 2010
Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cross ...
Enrico Defranchi, Claire Schalon, Mirko Messa, Franco Onofri, Fabio Benfenati, Didier Rognan   +5 more
doaj   +1 more source

A single cell observation of staurosporine effect on the Ca2+ signals in rat basophilic leukemia cells [PDF]

, 1990
A digital imaging fluorescence microscope was used to study the effect of a protein kinase inhibitor staurosporine on the antigen-dependent calcium signals in an individual rat basophilic leukemia cell (RBL-2H3). Although dose dependency of staurosporine
Nakanishi, Mamoru, Yoji Arata, Mamoru Nakanishi, Terao, Tadao, Hideharu Ikebuchi, Reiko Teshima, Ikebuchi, Hideharu, Miyagawa, Takehiko, Takehiko Miyagawa, Arata, Yoji, Teshima, Reiko, Tadao Terao   +11 more
core   +1 more source

Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis

Drug Design, Development and Therapy, 2014
Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma Reaction Biology Corp, Malvern, PA, USA Abstract: Caspases are currently known as the central executioners of the apoptotic pathways.
Wu J, Wang Y, Liang S, Ma H
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