Results 11 to 20 of about 25,920 (226)
Staurosporine-Induced Neuronal Apoptosis [PDF]
Experimental Neurology, 1995 Staurosporine, a nonselective protein kinase inhibitor, has been shown to induce apoptosis in several different nonneuronal cell types. We tested the hypothesis that staurosporine would also induce apoptosis in central neurons. Exposure of murine cortical cell cultures to 30-100 nM staurosporine induced concentration-dependent selective neuronal ...
J Y, Koh +7 more
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The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp [PDF]
Marine DrugsThis study aims to explore the potential inhibition effects of staurosporine isolated from a Streptomyces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities.
Grace Choi +7 more
doaj +2 more sources
Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications [PDF]
ChemMedChem, 2016 AbstractThe natural product staurosporine is a high‐affinity inhibitor of nearly all mammalian protein kinases. The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation of the 4′‐methylamine of the sugar moiety of staurosporine.
Alexander J. M. Disney +2 more
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Staurosporine suppresses replicon initiation in mammalian cells [PDF]
FEBS Letters, 1993 Replication in cellular replicons of mouse Ehrlich ascites, human CCRF‐CEM and hamster BHK‐21 cells was analyzed, after exposition of the cells to Staurosporine, by measuring the overall DNA synthesis rate, by alkaline sedimentation analysis of length distributions of growing daughter strand DNA and by DNA fibre autoradiography.
Gekeler, Volker +6 more
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Effect of Staurosporine on the Intracellular Localization of Hepatitis B Virus Core Protein [PDF]
Indonesian Journal of Biotechnology, 2007 protein is also including in the HBV genome targeting into the nucleus through modulating carboxyl residues by phosphorylation. Nuclear localication Signal (NLS) in HBV core protein is inside the virion structure and it must be unmasked in order to ...
Aris Haryanto +2 more
doaj +2 more sources
Staurosporine as an Antifungal Agent. [PDF]
Int J Mol SciStaurosporine (STS) was discovered in 1977 by Omura and colleagues during a chemical screening for microbial alkaloids. It was the first indolocarbazole compound isolated from a soil-dwelling bacterium, Streptomyces staurosporeus. STS was also found to have antifungal activity, but its potent protein kinase (PK) inhibitory properties, perhaps the most ...
Santos FC +3 more
europepmc +3 more sources
Communicative & Integrative Biology, 2013 The Ras GTPases comprising three main isoforms H-, N- and K-Ras operate at the plasma membrane as molecular switches in essential signaling pathways. Active concentration of the minor phospholipid phosphatidylserine in the inner leaflet of the plasma membrane contributes to the electrostatic potential that is required for K-Ras anchoring to the plasma ...
Cho, Kwang-Jin +2 more
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Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production [PDF]
, 2022 Aims Sequencing and genome analysis of two co-isolated streptomycetes, named BV410-1 and BV410-10, and the effect of their co-cultivation on the staurosporine production.
Gulder, Tobias A. M. +11 more
core +1 more source
Neuronal differentiation by analogs of staurosporine [PDF]
Neurochemistry International, 2010 RGC-5 cells are transformed cells that express several surface markers characteristic of neuronal precursor cells, but resemble glial cells morphologically and divide in culture. When treated with the apoptosis-inducing agent staurosporine, RGC-5 cells assume a neuronal morphology, extend neurites, stop dividing, and express ion channels without acute ...
Alex F, Thompson, Leonard A, Levin
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Staurosporine, a Prolyl Endopeptidase Inhibitor [PDF]
Agricultural and Biological Chemistry, 1990 (1990). Staurosporine, a Prolyl Endopeptidase Inhibitor. Agricultural and Biological Chemistry: Vol. 54, No. 11, pp. 3021-3022.
KIMURA, Ken-ichi +3 more
openaire +2 more sources