Results 11 to 20 of about 25,871 (229)
Staurosporine-induced neuronal apoptosis.
Experimental Neurology, 1995 Staurosporine, a nonselective protein kinase inhibitor, has been shown to induce apoptosis in several different nonneuronal cell types. We tested the hypothesis that staurosporine would also induce apoptosis in central neurons.
Wie, MB +7 more
core +3 more sources
Marine DrugsThis study aims to explore the potential inhibition effects of staurosporine isolated from a Streptomyces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities.
Grace Choi +7 more
doaj +2 more sources
Alkylation of staurosporine to derive a kinase probe for fluorescence applications [PDF]
ChemMedChem, 2016 The natural product staurosporine is a high-affinity inhibitor of nearly all mammalian protein kinases.The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation
Alexander J. M. Disney +5 more
core +5 more sources
Effect of Staurosporine on the Intracellular Localization of Hepatitis B Virus Core Protein
Indonesian Journal of Biotechnology, 2007 protein is also including in the HBV genome targeting into the nucleus through modulating carboxyl residues by phosphorylation. Nuclear localication Signal (NLS) in HBV core protein is inside the virion structure and it must be unmasked in order to ...
Aris Haryanto +2 more
doaj +2 more sources
Staurosporine suppresses replicon initiation in mammalian cells
FEBS Letters, 1993 Replication in cellular replicons of mouse Ehrlich ascites, human CCRF-CEM and hamster BHK-21 cells was analyzed, after exposition of the cells to Staurosporine, by measuring the overall DNA synthesis rate, by alkaline sedimentation analysis of length ...
Wilisch, Annette +13 more
core +3 more sources
Staurosporine as an Antifungal Agent. [PDF]
Int J Mol SciStaurosporine (STS) was discovered in 1977 by Omura and colleagues during a chemical screening for microbial alkaloids. It was the first indolocarbazole compound isolated from a soil-dwelling bacterium, Streptomyces staurosporeus. STS was also found to have antifungal activity, but its potent protein kinase (PK) inhibitory properties, perhaps the most ...
Santos FC +3 more
europepmc +3 more sources
Communicative & Integrative Biology, 2013 The Ras GTPases comprising three main isoforms H-, N- and K-Ras operate at the plasma membrane as molecular switches in essential signaling pathways. Active concentration of the minor phospholipid phosphatidylserine in the inner leaflet of the plasma membrane contributes to the electrostatic potential that is required for K-Ras anchoring to the plasma ...
Cho, Kwang-Jin +2 more
openaire +2 more sources
Neuronal differentiation by analogs of staurosporine [PDF]
Neurochemistry International, 2010 RGC-5 cells are transformed cells that express several surface markers characteristic of neuronal precursor cells, but resemble glial cells morphologically and divide in culture. When treated with the apoptosis-inducing agent staurosporine, RGC-5 cells assume a neuronal morphology, extend neurites, stop dividing, and express ion channels without acute ...
Alex F, Thompson, Leonard A, Levin
openaire +2 more sources
Staurosporine, a Prolyl Endopeptidase Inhibitor [PDF]
Agricultural and Biological Chemistry, 1990 (1990). Staurosporine, a Prolyl Endopeptidase Inhibitor. Agricultural and Biological Chemistry: Vol. 54, No. 11, pp. 3021-3022.
KIMURA, Ken-ichi +3 more
openaire +2 more sources
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis +11 more
core +1 more source