Results 11 to 20 of about 27,930 (225)

Staurosporine-Induced Neuronal Apoptosis

Experimental Neurology, 1995
Staurosporine, a nonselective protein kinase inhibitor, has been shown to induce apoptosis in several different nonneuronal cell types. We tested the hypothesis that staurosporine would also induce apoptosis in central neurons. Exposure of murine cortical cell cultures to 30-100 nM staurosporine induced concentration-dependent selective neuronal ...
J Y, Koh, M B, Wie, B J, Gwag, S L, Sensi, L M, Canzoniero, J, Demaro, C, Csernansky, D W, Choi   +7 more
openaire   +3 more sources

Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway

Tumor Biology, 2017
Staurosporine, which is an inhibitor of a broad spectrum of protein kinases, has shown cytotoxicity on several human cancer cells. However, the underlying mechanism is not well understood.
Youming Ding, Bin Wang, Xiaoyan Chen, Yu Zhou, Jianhui Ge   +4 more
doaj   +2 more sources

The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp

Marine Drugs
This study aims to explore the potential inhibition effects of staurosporine isolated from a Streptomyces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities.
Grace Choi, Eun-Young Lee, Dawoon Chung, Kichul Cho, Woon-Jong Yu, Sang-Jip Nam, Seong-Kook Park, Il-Whan Choi   +7 more
doaj   +2 more sources

Staurosporine [PDF]

Communicative & Integrative Biology, 2013
The Ras GTPases comprising three main isoforms H-, N- and K-Ras operate at the plasma membrane as molecular switches in essential signaling pathways. Active concentration of the minor phospholipid phosphatidylserine in the inner leaflet of the plasma membrane contributes to the electrostatic potential that is required for K-Ras anchoring to the plasma ...
Cho, Kwang-Jin, Park, Jin-Hee, Hancock, John F.   +2 more
openaire   +2 more sources

Neuronal differentiation by analogs of staurosporine [PDF]

Neurochemistry International, 2010
RGC-5 cells are transformed cells that express several surface markers characteristic of neuronal precursor cells, but resemble glial cells morphologically and divide in culture. When treated with the apoptosis-inducing agent staurosporine, RGC-5 cells assume a neuronal morphology, extend neurites, stop dividing, and express ion channels without acute ...
Alex F, Thompson, Leonard A, Levin
openaire   +2 more sources

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091), Dunai Zsuzsanna A., Barna Gabor, Petak Istvan, Mihalik Rudolf, Korcsmaros Tamas, Bauer Pal I., Imre Gergely   +27 more
core   +2 more sources

Staurosporine, a Prolyl Endopeptidase Inhibitor [PDF]

Agricultural and Biological Chemistry, 1990
(1990). Staurosporine, a Prolyl Endopeptidase Inhibitor. Agricultural and Biological Chemistry: Vol. 54, No. 11, pp. 3021-3022.
KIMURA, Ken-ichi, KAWAGUCHI, Noboru, YOSHIHAMA, Makoto, KAWANISHI, Gosei   +3 more
openaire   +2 more sources

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells

FEBS Open Bio, 2021
The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα ...
Lan Li, Haruhiko Sakiyama, Hironobu Eguchi, Daisaku Yoshihara, Noriko Fujiwara, Keiichiro Suzuki   +5 more
doaj   +1 more source

Modulatory Impact of Lamiaceae Metabolites on Apoptosis of Human Leukemia Cells

Frontiers in Pharmacology, 2022
Lamiaceae species are rich sources of biologically active compounds which have been applied in medicine since ancient times. Especially their antineoplastic properties have been thoroughly studied with respect to their putative application in ...
Izabela Berdowska, Bogdan Zieliński, Małgorzata Matusiewicz, Izabela Fecka   +3 more
doaj   +1 more source