Results 21 to 30 of about 4,109 (159)

Inhibition by Teriflunomide of Erythrocyte Cell Membrane Scrambling Following Energy Depletion, Oxidative Stress and Ionomycin

Cellular Physiology and Biochemistry, 2016
Background/Aims: Teriflunomide, an inhibitor of pyrimidine synthesis and thus proliferation of activated T and B lymphocytes, is successfully used for treatment of inflammatory disease. Teriflunomide has further been shown to trigger apoptosis of tumor cells and has thus been considered for the treatment of malignancy.
Jens Zierle, Rosi Bissinger, Florian Lang   +2 more
openaire   +4 more sources

Triggering of Suicidal Erythrocyte Death by Topotecan [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: The topoisomerase I inhibitor topotecan is used as treatment of various malignancies. The substance is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal
Rosi Bissinger, Ghada Bouguerra, Katja Stockinger, Salem Abbès, Florian Lang   +4 more
doaj   +2 more sources

Upregulation of Store Operated Ca2+ Channel Orai1, Stimulation of Ca2+ Entry and Triggering of Cell Membrane Scrambling in Platelets by Mineralocorticoid DOCA [PDF]

Kidney & Blood Pressure Research, 2014
Background/Aims: Mineralocorticoid excess leads to vascular injury, which is partially due to hypertension but in addition involves increased concentration of cytosolic Ca2+ concentration in platelets, key players in the pathophysiology of occlusive vascular disease.
Liu, Guoxing, Liu, Guilai, Al Zoubi, Kousi, Umbach, Anja Tasneem, Pelzl, Lisann, Borst, Oliver, Gawaz, Meinrad Paul, Lang, Florian   +7 more
core   +5 more sources

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The ubiquitously expressed Ca2+ Activated Cl- Channel Ano6 participates in the stimulation of cell membrane scrambling. Defective Ano6 underlies the Scott syndrome, an inherited bleeding disorder with impaired scrambling of plasma ...
Guoxing Liu, Guilai Liu, Hong Chen, Oliver Borst, Meinrad Gawaz, Andrea Vortkamp, Rainer Schreiber, Karl Kunzelmann, Florian Lang   +8 more
doaj   +2 more sources

Targeting glutathione by dimethylfumarate protects against experimental malaria by enhancing erythrocyte cell membrane scrambling

American Journal of Physiology-Cell Physiology, 2010
The balance between GSH-levels and oxidative stress is critical for cell survival. The GSH-levels of erythrocytes are dramatically decreased during infection with Plasmodium spp. We therefore investigated the consequences of targeting GSH for erythrocyte and Plasmodium survival in vitro and in vivo using dimethylfumarate (DMF) at therapeutically ...
Mehrdad, Ghashghaeinia, Diwakar, Bobbala, Thomas, Wieder, Saisudha, Koka, Jürgen, Brück, Birgit, Fehrenbacher, Martin, Röcken, Martin, Schaller, Florian, Lang, Kamran, Ghoreschi   +9 more
openaire   +3 more sources

Chapter Twenty‐One Organelle Intermixing and Membrane Scrambling in Cell Death

, 2008
In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
Degli Esposti, Mauro
core   +4 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Amiodarone [PDF]

Cellular Physiology and Biochemistry, 2007
Side effects of amiodarone, an effective antiarrhythmic drug, include anemia, which may be caused by decreased formation or accelerated death of erythrocytes. Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the cell surface.
Jan P, Nicolay, Peter J, Bentzen, Mehrdad, Ghashghaeinia, Thomas, Wieder, Florian, Lang   +4 more
openaire   +2 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Nystatin [PDF]

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractThe antifungal ionophore nystatin dissipates the Na+ and K+ gradients across the cell membrane, leading to cellular gain of Na+ and cellular loss of K+. The increase of cellular Na+ concentration may result in Ca2+ accumulation in exchange for Na+.
Abaid, Malik, Rosi, Bissinger, Kashif, Jilani, Florian, Lang   +3 more
openaire   +2 more sources

Lipopeptides in the Triggering of Erythrocyte Cell Membrane Scrambling [PDF]

Cellular Physiology and Biochemistry, 2008
Sepsis is paralleled by anemia, an effect partially resulting from eryptosis, the suicidal death of erythrocytes. Eryptosis is characterized by cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Pathogen-induced eryptosis may partially result from interaction of bacterial cell wall components such as lipoproteins with
Kan, Wang, Hasan, Mahmud, Michael, Föller, Raja, Biswas, Karl S, Lang, Erwin, Bohn, Friedrich, Götz, Florian, Lang   +7 more
openaire   +2 more sources

Lipid scrambling facilitates membrane vesiculation through decreasing membrane stiffness

, 2023
Membrane blebbing plays important roles in cell migration, cytokinesis, apoptosis, as well as extracellular vesicle formation for intercellular communication.
Revathi, Adhvikaa A., Levental, Kandice R., Wang, Hongyin, Lorent, Joseph, Levental, Ilya   +4 more
core   +1 more source