Results 21 to 30 of about 5,974,193 (263)

Inhibition by Teriflunomide of Erythrocyte Cell Membrane Scrambling Following Energy Depletion, Oxidative Stress and Ionomycin

Cellular Physiology and Biochemistry, 2016
Background/Aims: Teriflunomide, an inhibitor of pyrimidine synthesis and thus proliferation of activated T and B lymphocytes, is successfully used for treatment of inflammatory disease. Teriflunomide has further been shown to trigger apoptosis of tumor cells and has thus been considered for the treatment of malignancy.
Jens Zierle, Rosi Bissinger, Florian Lang   +2 more
openaire   +4 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Amiodarone [PDF]

Cellular Physiology and Biochemistry, 2007
Side effects of amiodarone, an effective antiarrhythmic drug, include anemia, which may be caused by decreased formation or accelerated death of erythrocytes. Suicidal erythrocyte death (eryptosis) is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the cell surface.
Jan P, Nicolay, Peter J, Bentzen, Mehrdad, Ghashghaeinia, Thomas, Wieder, Florian, Lang   +4 more
openaire   +2 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Nystatin [PDF]

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractThe antifungal ionophore nystatin dissipates the Na+ and K+ gradients across the cell membrane, leading to cellular gain of Na+ and cellular loss of K+. The increase of cellular Na+ concentration may result in Ca2+ accumulation in exchange for Na+.
Abaid, Malik, Rosi, Bissinger, Kashif, Jilani, Florian, Lang   +3 more
openaire   +2 more sources

Triggering of Erythrocyte Cell Membrane Scrambling by Salinomycin [PDF]

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractSalinomycin, a polyether ionophore antibiotic effective against a variety of pathogens, has been shown to trigger apoptosis of cancer cells and cancer stem cells. The substance is thus considered for the treatment of malignancy. Salinomycin compromises tumour cell survival at least in part by interference with mitochondrial function ...
Rosi, Bissinger, Abaid, Malik, Kashif, Jilani, Florian, Lang   +3 more
openaire   +2 more sources

Scrambling of Phospholipids Activates Red Cell Membrane Cholesterol [PDF]

Biochemistry, 2007
Cholesterol is predicted to associate more strongly with the outer than the inner leaflet of plasma membrane bilayers based on the relative in vitro affinities of their phospholipids. Complex formation with the high-affinity species (especially saturated sphingomyelins) is said to reduce the chemical activity (escape potential or fugacity) of the ...
Yvonne, Lange, Jin, Ye, Theodore L, Steck   +2 more
openaire   +2 more sources

Phospholipid scrambling on the plasma membrane. [PDF]

, 2014
Regulated Cell Death Part A: Apoptotic MechanismsPhospholipids are asymmetrically distributed at plasma membrane in normal cells, and scrambled in various biological situations such as blood clotting and apoptotic cell death. Recent studies revealed that
Suzuki, Jun, Nagata, Shigekazu, Shigekazu Nagata, Jun Suzuki   +3 more
core   +1 more source

Lipid scrambling facilitates membrane vesiculation through decreasing membrane stiffness

, 2023
Membrane blebbing plays important roles in cell migration, cytokinesis, apoptosis, as well as extracellular vesicle formation for intercellular communication.
Revathi, Adhvikaa A., Levental, Kandice R., Wang, Hongyin, Lorent, Joseph, Levental, Ilya, Hongyin Wang, Adhvikaa A. Revathi, Joseph H. Lorent, Ilya Levental, Kandice R. Levental   +9 more
core   +1 more source

Triggering of Suicidal Erythrocyte Death by Topotecan

Cellular Physiology and Biochemistry, 2015
Background/Aims: The topoisomerase I inhibitor topotecan is used as treatment of various malignancies. The substance is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal
Rosi Bissinger, Ghada Bouguerra, Katja Stockinger, Salem Abbès, Florian Lang   +4 more
doaj   +1 more source

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Objective— Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation.
Münzer, Patrick, Borst, Oliver, Walker, Britta, Schmid, Evi, Feijge, Marion A. H., Cosemans, Judith M. E. M., Chatterjee, Madhumita, Schmidt, Eva-Maria, Schmidt, Sebastian, Towhid, Syeda T., Leibrock, Christina, Elvers, Margitta, Schaller, Martin, Seizer, Peter, Ferlinz, Klaus, May, Andreas E., Gulbins, Erich, Heemskerk, Johan W. M., Gawaz, Meinrad, Lang, Florian   +19 more
openaire   +3 more sources

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The ubiquitously expressed Ca2+ Activated Cl- Channel Ano6 participates in the stimulation of cell membrane scrambling. Defective Ano6 underlies the Scott syndrome, an inherited bleeding disorder with impaired scrambling of plasma ...
Guoxing Liu, Guilai Liu, Hong Chen, Oliver Borst, Meinrad Gawaz, Andrea Vortkamp, Rainer Schreiber, Karl Kunzelmann, Florian Lang   +8 more
doaj   +1 more source