Results 21 to 30 of about 3,949 (239)

Immune cell activation produces locally scrambled foci of plasma membrane lipids. [PDF]

Faraday Discuss
We show that phosphatidylserine and phosphatidylethanolamine appear as transient foci on the plasma membrane external leaflet following immune receptor-mediated activation of mast cells.
Sputay D, Doktorova M, Chan SH, Guo EH, Wang HY, Lorent JH, Levental I, Levental KR.   +7 more
europepmc   +4 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Methyldopa

Kidney and Blood Pressure Research, 2008
Methyldopa is used for treatment of hypertension in pregnancy. Side effects of methyldopa include anemia, which could result from decreased formation or accelerated death of circulating erythrocytes. Several drugs cause anemia by triggering of suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling,
Hasan, Mahmud, Michael, Föller, Florian, Lang   +2 more
openaire   +2 more sources

Triggering of Suicidal Erythrocyte Death by Topotecan

Cellular Physiology and Biochemistry, 2015
Background/Aims: The topoisomerase I inhibitor topotecan is used as treatment of various malignancies. The substance is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal
Rosi Bissinger, Ghada Bouguerra, Katja Stockinger, Salem Abbès, Florian Lang   +4 more
doaj   +1 more source

Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Objective— Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation.
Münzer, Patrick, Borst, Oliver, Walker, Britta, Schmid, Evi, Feijge, Marion A. H., Cosemans, Judith M. E. M., Chatterjee, Madhumita, Schmidt, Eva-Maria, Schmidt, Sebastian, Towhid, Syeda T., Leibrock, Christina, Elvers, Margitta, Schaller, Martin, Seizer, Peter, Ferlinz, Klaus, May, Andreas E., Gulbins, Erich, Heemskerk, Johan W. M., Gawaz, Meinrad, Lang, Florian   +19 more
openaire   +3 more sources

Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

Cellular Physiology and Biochemistry, 2015
Background/Aims: The ubiquitously expressed Ca2+ Activated Cl- Channel Ano6 participates in the stimulation of cell membrane scrambling. Defective Ano6 underlies the Scott syndrome, an inherited bleeding disorder with impaired scrambling of plasma ...
Guoxing Liu, Guilai Liu, Hong Chen, Oliver Borst, Meinrad Gawaz, Andrea Vortkamp, Rainer Schreiber, Karl Kunzelmann, Florian Lang   +8 more
doaj   +1 more source

Inhibition of Erythrocyte Cell Membrane Scrambling Following Energy Depletion and Hyperosmotic Shock by Alectinib [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: The anaplastic lymphoma kinase (ALK) inhibitor alectinib is clinically used for the treatment of ALK positive non-small-cell lung cancer. At least in part the substance is effective by triggering suicidal death or apoptosis of tumor cells. Erythrocytes are lacking mitochondria and nuclei, key organelles of apoptosis but are, similar to
Abdulla  Al Mamun Bhuyan, Florian Lang
openaire   +3 more sources

Enhanced Eryptosis Following Auranofin Exposure

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antiinflammatory, antimicrobial and anticancer drug auranofin has previously been shown to trigger apoptosis, the suicidal death of nucleated cells. Side effects of the drug include anaemia.
Kousi Alzoubi, Jasmin Egler, Majed Abed, Florian Lang   +3 more
doaj   +1 more source

Triggering of Suicidal Erythrocyte Death by Penta-O-galloyl-β-d-glucose

Toxins, 2013
The polyphenolic 1,2,3,4,6-penta-O-galloyl-beta-d-glucose from several medicinal herbs triggers apoptosis and has, thus, been proposed for treatment of malignancy. The substance is at least partially effective through caspase activation.
Kousi Alzoubi, Sabina Honisch, Majed Abed, Florian Lang   +3 more
doaj   +1 more source

Embelin-Induced Phosphatidylserine Translocation in the Erythrocyte Cell Membrane

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antihelminthic, contraceptive, anti-inflammatory and anticancer phytochemical embelin is at least in part effective against malignancy by inducing suicidal death or apoptosis of tumor cells.
Ghada Bouguerra, Omar Aljanadi, Rosi Bissinger, Salem Abbès, Florian Lang   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source