Stimulation of Erythrocyte Cell Membrane Scrambling by Gedunin [PDF]
Cellular Physiology and Biochemistry, 2014 Background/Aims: Gedunin, an inhibitor of heat shock protein HSP90, triggers apoptosis of tumor cells and is thus effective against malignancy. Moreover, the drug has antimalarial potency.
Adrian Lupescu +4 more
doaj +4 more sources
Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation [PDF]
Cellular and Molecular Immunology, 2021 One of the hallmarks of live cells is the asymmetric distribution of lipids across their plasma membrane. Changes in this asymmetry due to lipid "scrambling" result in phosphatidylserine exposure at the cell surface that is detected by annexin V staining.
Ning Wu, André Veillette
exaly +3 more sources
Stimulation of Erythrocyte Cell Membrane Scrambling by C-Reactive Protein [PDF]
Cellular Physiology and Biochemistry, 2017 Background: Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine-translocation, is triggered by fever and inflammation.
Majed Abed +6 more
doaj +3 more sources
Extreme deformability of insect cell membranes is governed by phospholipid scrambling [PDF]
Cell Reports, 2021 Organization of dynamic cellular structure is crucial for a variety of cellular functions. In this study, we report that Drosophila and Aedes have highly elastic cell membranes with extremely low membrane tension and high resistance to mechanical stress.
Masato Umeda +2 more
exaly +4 more sources
Scrambling of Phospholipids Activates Red Cell Membrane Cholesterol [PDF]
Biochemistry, 2007 Cholesterol is predicted to associate more strongly with the outer than the inner leaflet of plasma membrane bilayers based on the relative in vitro affinities of their phospholipids. Complex formation with the high-affinity species (especially saturated sphingomyelins) is said to reduce the chemical activity (escape potential or fugacity) of the ...
Theodore Steck
exaly +3 more sources
Triggering of Erythrocyte Cell Membrane Scrambling by Salinomycin [PDF]
Basic and Clinical Pharmacology and Toxicology, 2014 AbstractSalinomycin, a polyether ionophore antibiotic effective against a variety of pathogens, has been shown to trigger apoptosis of cancer cells and cancer stem cells. The substance is thus considered for the treatment of malignancy. Salinomycin compromises tumour cell survival at least in part by interference with mitochondrial function ...
Florian Lang
exaly +3 more sources
Structural Dynamics, 2021 Phospholipid transbilayer movement (flip-flop) in the plasma membrane is regulated by membrane proteins to maintain cell homeostasis and interact with other cells.
Hiroyuki Nakao +4 more
doaj +2 more sources
TMEM16E-mediated macropinocytosis promotes cell survival under acidic stress [PDF]
Cellular and Molecular Life SciencesTMEM16E is a transmembrane protein that functions both as a phospholipid scramblase and a non-selective ion channel, playing a critical role in cellular ion transport and membrane dynamics.
Jung-Eun Kim +2 more
doaj +2 more sources
Effect of a scramblase activator upon lipid and probe scrambling and membrane domain formation in HEK 293T cells. [PDF]
Faraday DiscussA model for how loss of asymmetry due to lipid scrambling may change membrane domain formation.
Kakuda S, London E.
europepmc +4 more sources
Immune cell activation produces locally scrambled foci of plasma membrane lipids.
Faraday DiscussWe show that phosphatidylserine and phosphatidylethanolamine appear as transient foci on the plasma membrane external leaflet following immune receptor-mediated activation of mast cells.
Sputay D +7 more
europepmc +3 more sources