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Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production [PDF]

Mathematical and Computational Applications
The ability of a cell to keep its volume constant irrespective of intra- and extracellular conditions is essential for cellular homeostasis and survival.
Riccardo Sacco, Greta Chiaravalli, Giovanna Guidoboni, Anita Layton, Gal Antman, Keren Wood Shalem, Alice Verticchio, Brent Siesky, Alon Harris   +8 more
doaj   +2 more sources

A mechano-osmotic feedback couples cell volume to the rate of cell deformation [PDF]

eLife, 2022
Mechanics has been a central focus of physical biology in the past decade. In comparison, how cells manage their size is less understood. Here, we show that a parameter central to both the physics and the physiology of the cell, its volume, depends on a ...
Larisa Venkova, Amit Singh Vishen, Sergio Lembo, Nishit Srivastava, Baptiste Duchamp, Artur Ruppel, Alice Williart, Stéphane Vassilopoulos, Alexandre Deslys, Juan Manuel Garcia Arcos, Alba Diz-Muñoz, Martial Balland, Jean-François Joanny, Damien Cuvelier, Pierre Sens, Matthieu Piel   +15 more
doaj   +2 more sources

The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity [PDF]

eLife
While the ratio of nuclei to cell volume is well regulated, it remains largely unexplored in multinucleate organisms. The koji-fungus Aspergillus oryzae, traditionally used in Japanese brewing and fermentation for over a thousand years, is now widely ...
Ayaka Itani, Haruto Motomura, Ken Oda, Hideyuki Yamashita, Kanae Sakai, Ken-ichi Kusumoto, Shinsuke Shigeto, Takehiko Ichikawa, Hosain Mohammad Mubarak, Takeshi Fukuma, Takuya Katayama, Jun-ichi Maruyama, Shunsuke Masuo, Naoki Takaya, Norio Takeshita   +14 more
doaj   +2 more sources

Mechanisms of cell volume regulation and possible nature of the cell volume sensor

Pathophysiology, 2001
In animal organisms, cell volume undergoes dynamic changes in many physiological and pathological processes. To protect themselves against lysis and apoptosis and to maintain an optimal concentration of intracellular enzymes and metabolites, most animal cells actively regulate their volume.
Alexander A Mongin, Sergei N Orlov
exaly   +3 more sources

WNK kinases sense molecular crowding and rescue cell volume via phase separation. [PDF]

Cell, 2022
Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR.   +22 more
europepmc   +2 more sources

Seasonal Variation in Viral Infection Rates and Cell Sizes of Infected Prokaryotes in a Large and Deep Freshwater Lake (Lake Biwa, Japan)

Frontiers in Microbiology, 2021
As viruses regulate prokaryotic abundance and the carbon cycle by infecting and lysing their prokaryotic hosts, the volume of infected prokaryotes is an important parameter for understanding the impact of viruses on aquatic environments.
Shang Shen, Yoshihisa Shimizu
doaj   +1 more source

Physical basis of the cell size scaling laws

eLife, 2023
Cellular growth is the result of passive physical constraints and active biological processes. Their interplay leads to the appearance of robust and ubiquitous scaling laws relating linearly cell size, dry mass, and nuclear size.
Romain Rollin, Jean-François Joanny, Pierre Sens   +2 more
doaj   +1 more source

The limiting effect of genome size on xylem vessel diameter is shifted by environmental pressures in seed plants

Plant Direct, 2022
Current and previous studies have extensively studied the physiological and ecological consequences of genome size (GS) on plants because of the limiting effect of GS on cell size.
Xiangyan Feng, Linfei Zhong, Hai Zhou, Jingwen Bi, Huma Batool, Xintan Zhang, Wenzhi Zhao   +6 more
doaj   +1 more source

Putting scaling laws on a physical foundation

eLife, 2023
As a cell changes size during the cell cycle, why does its density remain constant?
Yiyang Ye, Jie Lin
doaj   +1 more source

Dynamics of cell mass and size control in multicellular systems and the human body

Journal of Biological Research - Thessaloniki, 2022
Cellular processes, in particular homeostasis and growth, require an intricate and complex exchange of matter between a cell and its surroundings. Yet experimental difficulties have prevented a detailed description of the dynamics of a cell’s mass and ...
David Martinez-Martin
doaj   +1 more source