Results 31 to 40 of about 15,438,001 (312)

Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation

Cells
Severe asthma is characterized by increased cell volume (hypertrophy) and enhanced contractile function (hyperresponsiveness) of the airway smooth muscle cells (ASMCs). The causative relationship and underlying regulatory mechanisms between them, however,
Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng   +8 more
doaj   +1 more source

Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress

Frontiers in Cellular Neuroscience, 2017
Normal nervous system function is critically dependent on the balance of water and ions in the extracellular space (ECS). Pathological reduction in brain interstitial osmolarity results in osmotically-driven flux of water into cells, causing cellular ...
Thomas R. Murphy, Thomas R. Murphy, David Davila, David Davila, Nicholas Cuvelier, Nicholas Cuvelier, Leslie R. Young, Leslie R. Young, Kelli Lauderdale, Kelli Lauderdale, Devin K. Binder, Devin K. Binder, Todd A. Fiacco, Todd A. Fiacco   +13 more
doaj   +1 more source

On the Distribution of Red Cell Volumes [PDF]

Blood, 1968
Abstract A large number of red cell volume distribution curves can be generated on the same sample of blood by manipulating the length of the Coulter Counter aperture and the shape of the red cell. Curves derived from sphered red cells flowing through an aperture 70 x 98µ long, or longer appear to be relatively free from artefacts and ...
openaire   +2 more sources

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

, 2017
Cellular blebbing, caused by local alterations in cellsurface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive.
Madlen Hubert, Vidal-Quadras, Maite, Larsson, Elin, Richard Lundmark, Jeanette Blomberg, Blomberg, Jeanette,, Hubert, Madlen, Hubert, Madlen,, Mikkel Roland Holst, Blomberg, Jeanette, Holst, Mikkel Roland, Holst, Mikkel Roland,, Song, Jie, Jie Song, Landström, Maréne, Lundmark, Richard, Maite Vidal-Quadras, Elin Larsson, Vidal-Quadras, Maite,, Landström, Maréne,, Lundborg, Magnus, Magnus Lundborg, Song, Jie,, Maréne Landström, Lundmark, Richard,, Larsson, Elin,, Lundborg, Magnus,   +26 more
core   +1 more source

Cell Competition and its role in the regulation of cell fitness from development to cancer [PDF]

, 2016
Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals that eliminates those cells that, although viable, are less fit than their neighbors. An important implication of cell competition is that cellular fitness is not only
di gregorio, A, Rodriguez, T, Bowling, S
core   +1 more source

p38-mediated cell growth and survival drive rapid embryonic wound repair

Cell Reports, 2021
Summary: Embryos repair wounds rapidly, with no inflammation or scarring, in a process that involves polarization of the actomyosin cytoskeleton. Actomyosin polarization results in the assembly of a contractile cable around the wound that drives wound ...
Gordana Scepanovic, Miranda Victoria Hunter, Ran Kafri, Rodrigo Fernandez-Gonzalez   +3 more
doaj   +1 more source

Cell Volume Regulation and Apoptotic Volume Decrease in Rat Distal Colon Superficial Enterocytes

, 2013
Background: The colon epithelium is physiologically exposed to osmotic stress, and the activation of cell volume regulation mechanisms is essential in colonocyte physiology.
Roberto Caricato, Maria Elena Giordano, Trifone Schettino, GIORDANO, Maria Elena, Stefania Antico, LIONETTO, Maria Giulia, Maria Giulia Lionetto, CARICATO, Roberto, SCHETTINO, Trifone, S. Antico   +9 more
core   +1 more source

Cell Volume Regulation in Liver

Kidney and Blood Pressure Research, 1988
The maintenance of liver cell volume in isotonic extracellular fluid requires the continuous supply of energy: sodium is extruded in exchange for potassium by the sodium/potassium ATPase, conductive potassium efflux creates a cell-negative membrane potential, which expelles chloride through conductive pathways.
J, Graf, P, Haddad, D, Haeussinger, F, Lang   +3 more
openaire   +2 more sources

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source