Results 51 to 60 of about 2,031,505 (263)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
SEARCH FOR CELL VOLUME SENSORS: AN UPDATE
Бюллетень сибирской медицины, 2013 Cell volume changes affect a plethora of cellular functions including macromolecular synthesis and catabolism, cell proliferation, differentiation and death.
S. N. Orlov, R. Grygorszyk
doaj
GABA not only a neurotransmitter: osmotic regulation by GABAAR signalling
Frontiers in Cellular Neuroscience, 2012 In neurons the anionic channel γ-aminobutyric (GABA) A receptor (GABAAR) plays a central role in mediating both the neurotrophic and neurotransmitter role of GABA. Activation of this receptor by GABA also affects the function of non-neuronal cells in the
Tiziana eCesetti +2 more
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Relationship of nuclear genome size, cell volume and nuclei volume in endosperm of Sorghum bicolor
Acta Biologica Slovenica, 2015 Endosperm cells of Sorghum bicolor undergo several rounds of endoreplication during seed development, resulting in somatic endopolyploidy with cells containing 3 C to 96 C nuclei (1 C represents the amount of DNA in an unreplicated haploid genome ...
Aleš Kladnik
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Effect of Nitrogen Starvation on Biomass Yield and Biochemical Constituents of Rhodomonas sp.
Frontiers in Marine Science, 2020 The microalgae Rhodomonas sp. is known as an excellent feed source for live feed organisms such as copepods. The main benefits of feeding Rhodomonas to live feed animals are attributed to the relative high polyunsaturated fatty acid (PUFA) level, the ...
Christos Latsos +3 more
doaj +1 more source
Cell Volume Regulation in Lymphocytes
Kidney and Blood Pressure Research, 1988 This article reviews what is known about the volume regulatory responses of lymphocytes. We present a discussion of recent data and hypotheses pertaining to the underlying mechanisms in regulatory volume increase (RVI) and regulatory volume decrease (RVD).
C, Deutsch, S C, Lee
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Size and carbon content of sub-seafloor microbial cells at Landsort Deep, Baltic Sea
Frontiers in Microbiology, 2016 The discovery of a microbial ecosystem in ocean sediments has evoked interest in life under extreme energy limitation and its role in global element cycling.
Stefan Braun +8 more
doaj +1 more source