Results 11 to 20 of about 4,109 (159)

Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine

Cellular Physiology and Biochemistry, 2016
Background/Aims: The analkaloid drug quinine is utilized mainly for the chemoprophylaxis of malaria. The multiple side effects of quinine include hemolytic anemia and hemolytic uremic syndrome, disorders involving suicidal erythrocyte death or eryptosis,
Morena Mischitelli, Mohamed Jemaà, Mustafa Almasry, Caterina Faggio, Florian Lang   +4 more
doaj   +5 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Adarotene

Cellular Physiology and Biochemistry, 2017
Background/Aims: The atypical retinoid E23-(40-hydroxyl-30-adamantylbiphenyl-4-yl) acrylic acid (ST1926, adarotene) is used in the treatment of malignancy. The effect of ST1926 is at least in part due to stimulation of apoptosis.
Morena Mischitelli, Mohamed Jemaàa, MyriamFezai Fezai, Mustafa Almasry, Florian Lang, Caterina Faggio   +5 more
doaj   +4 more sources

Camalexin-Induced Cell Membrane Scrambling and Cell Shrinkage in Human Erythrocytes [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: The thaliana phytoalexin Camalexin has been proposed for the treatment of malignancy. Camalexin counteracts tumor growth in part by stimulation of suicidal death or apoptosis of tumor cells.
Mustafa Almasry, Mohamed Jemaà, Morena Mischitelli, Florian Lang, Caterina Faggio   +4 more
doaj   +6 more sources

Stimulating Effect of Terfenadine on Erythrocyte Cell Membrane Scrambling [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: The antihistaminic drug Terfenadine may trigger apoptosis of tumor cells, an effect unrelated to its effect on histamine receptors.
Elena Signoretto, Michela Castagna, Abdulla Al Mamun Bhuyan, Florian Lang   +3 more
doaj   +6 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Mitotane [PDF]

Cellular Physiology and Biochemistry, 2014
Background: Mitotane (1,1-dichloro-2-[o-chlorophenyl]-2-[p-chlorophenyl]ethane), a cytostatic drug used for the treatment of adrenocortical carcinomas, is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, eryptosis
Janin Jacobi, Elisabeth Lang, Rosi Bissinger, Leonie Frauenfeld, Paola Modicano, Caterina Faggio, Majed Abed, Florian Lang   +7 more
doaj   +7 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by Gedunin [PDF]

Cellular Physiology and Biochemistry, 2014
Background/Aims: Gedunin, an inhibitor of heat shock protein HSP90, triggers apoptosis of tumor cells and is thus effective against malignancy. Moreover, the drug has antimalarial potency.
Adrian Lupescu, Rosi Bissinger, Jamshed Warsi, Kashif Jilani, Florian Lang   +4 more
doaj   +5 more sources

Stimulation of Erythrocyte Cell Membrane Scrambling by C-Reactive Protein [PDF]

Cellular Physiology and Biochemistry, 2017
Background: Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine-translocation, is triggered by fever and inflammation.
Majed Abed, Christian Thiel, Syeda T. Towhid, Kousi Alzoubi, Sabina Honisch, Florian Lang, Alfred Königsrainer   +6 more
doaj   +4 more sources

Inhibition of Erythrocyte Cell Membrane Scrambling Following Energy Depletion and Hyperosmotic Shock by Alectinib [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: The anaplastic lymphoma kinase (ALK) inhibitor alectinib is clinically used for the treatment of ALK positive non-small-cell lung cancer. At least in part the substance is effective by triggering suicidal death or apoptosis of tumor cells. Erythrocytes are lacking mitochondria and nuclei, key organelles of apoptosis but are, similar to
Abdulla  Al Mamun Bhuyan, Florian Lang
openaire   +4 more sources

Embelin-Induced Phosphatidylserine Translocation in the Erythrocyte Cell Membrane [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antihelminthic, contraceptive, anti-inflammatory and anticancer phytochemical embelin is at least in part effective against malignancy by inducing suicidal death or apoptosis of tumor cells.
Ghada Bouguerra, Omar Aljanadi, Rosi Bissinger, Salem Abbès, Florian Lang   +4 more
doaj   +2 more sources

Immune cell activation produces locally scrambled foci of plasma membrane lipids. [PDF]

Faraday Discuss
We show that phosphatidylserine and phosphatidylethanolamine appear as transient foci on the plasma membrane external leaflet following immune receptor-mediated activation of mast cells.
Sputay D, Doktorova M, Chan SH, Guo EH, Wang HY, Lorent JH, Levental I, Levental KR.   +7 more
europepmc   +5 more sources