Results 51 to 60 of about 2,020 (175)

Storage of Erythrocytes Induces Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: Similar to apoptosis of nucleated cells, red blood cells (RBC) can undergo suicidal cell death - called eryptosis. It is characterized by cell shrinkage and phosphatidylserine translocation.
Elisabeth Lang, Vitaly I. Pozdeev, Haifeng C. Xu, Prashant V. Shinde, Kristina Behnke, Junnat M. Hamdam, Erik Lehnert, Rüdiger E. Scharf, Florian Lang, Dieter Häussinger, Karl S. Lang, Philipp A. Lang   +11 more
doaj   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, Volume 66, Issue 7, Page 1299-1315, July 2026.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Sulindac Sulfide – Induced Stimulation of Eryptosis [PDF]

Cellular Physiology and Biochemistry, 2012
Sulindac sulfide, a non-steroidal anti-inflammatory drug (NSAID), stimulates apoptosis of tumor cells and is thus effective against malignancy. In analogy to apoptosis of nucleated cells, erythrocytes may undergo eryptosis, an apoptosis-like suicidal erythrocyte death, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine-
Zbidah, Mohanad, Lupescu, Adrian, Yang, Wenting, Bosc, Anastasia, Jilani, Kashif, Shaik, Nazneen, Lang, Florian   +6 more
openaire   +3 more sources

In Vitro Induction of Eryptosis by Uremic Toxins and Inflammation Mediators in Healthy Red Blood Cells

, 2022
Eryptosis is the stress-induced RBC (red blood cell) death mechanism. It is known that eryptosis is largely influenced by plasma and blood composition, and that it is accelerated in patients affected by chronic kidney disease (CKD). The aim of this study
Battaglia, Giovanni Giorgio, Ronco, Claudio, Monica Zanella, Giovanni Giorgio Battaglia, Sabrina Milan Manani, Anna Clementi, Mattiotti, Maria, Zanella, Monica, Claudio Ronco, Maria Mattiotti, Grazia Maria Virzì, Clementi, Anna, Virzì, Grazia Maria, Milan Manani, Sabrina   +13 more
core   +1 more source

Stimulation of Hemolysis and Eryptosis by β-Caryophyllene Oxide

Life, 2023
Background: Eryptosis stimulated by anticancer drugs can lead to anemia in patients. β-caryophyllene oxide (CPO) is an anticancer sesquiterpene present in various plants; however, its effect on the structure and function of human red blood cells (RBCs) remains unexplored.
Sumiah A. Alghareeb, Mohammad A. Alfhili, Jawaher Alsughayyir   +2 more
openaire   +3 more sources

Carmustine-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane

Toxins, 2013
The nitrosourea alkylating agent, carmustine, is used as chemotherapeutic drug in several malignancies. The substance triggers tumor cell apoptosis. Side effects of carmustine include myelotoxicity with anemia.
Kashif Jilani, Florian Lang
doaj   +1 more source

Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways

Toxins, 2018
It is hypothesized that the uremic toxin indoxyl sulfate (IS) plays a role in the pathogenesis of renal anemia. To further explore that hypothesis, we examined the effects of IS on reactive oxygen species (ROS) production, levels of reduced glutathione ...
Gabriela Ferreira Dias, Natalia Borges Bonan, Thiago Maass Steiner, Sara Soares Tozoni, Silvia Rodrigues, Lia Sumie Nakao, Viktoriya Kuntsevich, Roberto Pecoits Filho, Peter Kotanko, Andréa N. Moreno-Amaral   +9 more
doaj   +1 more source

Eryptosis: Programmed Death of Nucleus-Free, Iron-Filled Blood Cells

Cells, 2022
Human erythrocytes are organelle-free cells packaged with iron-containing hemoglobin, specializing in the transport of oxygen. With a total number of approximately 25 trillion cells per individual, the erythrocyte is the most abundant cell type not only ...
Peter Dreischer, Michael Duszenko, Jasmin Stein, Thomas Wieder   +3 more
doaj   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Estramustine-Induced Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2013
Background: The nitrogen mustard derivative of estradiol-17β-phosphate estramustine is used for the treatment of prostate cancer. Estramustine may trigger suicidal death of cancer cells. Side effects of estramustine include anemia.
Rosi Bissinger, Paola Modicano, Leonie Frauenfeld, Elisabeth Lang, Janin Jacobi, Caterina Faggio, Florian Lang   +6 more
doaj   +1 more source