Results 71 to 80 of about 1,400 (161)

Modulation of Autophagy by Ursolic and Betulinic Acids: Distinct Cytotoxic and Membrane‐Disruption in Malignant and Nonmalignant Cells

Cell Biology International, Volume 49, Issue 11, Page 1518-1536, November 2025.
ABSTRACT Autophagy is a critical adaptive mechanism in tumor cells that promotes survival under stress, but when dysregulated, it may trigger programmed cell death. The pentacyclic triterpenoids betulinic acid (BA) and ursolic acid (UA) are structurally related compounds that modulate autophagy; however, comparative insights into their effects on ...
Waleska Kerllen Martins, Tayana Mazin Tsubone, Chimara Emilia Nascimento Sanches, Cleidiane de Sousa Rocha, Ricardo Scarparo Navarro, Beatriz Simonsen Stolf, Susana Nogueira Diniz, Rosangela Itri, Mauricio S. Baptista   +8 more
wiley   +1 more source

Induction of Suicidal Erythrocyte Death by Novobiocin

Cellular Physiology and Biochemistry, 2014
Background: Novobiocin, an aminocoumarin antibiotic, interferes with heat shock protein 90 and hypoxia inducible factor dependent gene expression and thus compromises cell survival.
Adrian Lupescu, Rosi Bissinger, Tabea Herrmann, Gergely Oswald, Kashif Jilani, Florian Lang   +5 more
doaj   +1 more source

Stimulation of Erythrocyte Cell Membrane Scrambling by Gedunin

Cellular Physiology and Biochemistry, 2014
Background/Aims: Gedunin, an inhibitor of heat shock protein HSP90, triggers apoptosis of tumor cells and is thus effective against malignancy. Moreover, the drug has antimalarial potency.
Adrian Lupescu, Rosi Bissinger, Jamshed Warsi, Kashif Jilani, Florian Lang   +4 more
doaj   +1 more source

Patulin-Induced Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2013
Background: Patulin, the most common mycotoxin in apples and apple-derived products, triggers apoptosis and has thus been considered for the treatment of cancer. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis,
Adrian Lupescu, Kashif Jilani, Mohanad Zbidah, Florian Lang   +3 more
doaj   +1 more source

Circulating Erythrocyte‐ and Endothelial‐Derived Microvesicles as Biomarkers of Hemolysis and Clinical Severity in Sickle Cell Disease

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT Sickle cell disease (SCD) is a monogenic disorder caused by the presence of hemoglobin S (Hb S) and is associated with a wide range of clinical complications, including hemolytic anemia, vaso‐occlusive crises (VOC), and acute chest syndrome (ACS).
Khouloud Khalfaoui, Mariem Chebbi, Oussema Souiai, Ilhem Ben Fraj, Monia Ben Khaled, Amine Hableni, Mbarka Barmate, Dorra Chaouachi, Fethi Mellouli, Monia Ouederni, Ines Safra, Samia Menif, Imen Moumni   +12 more
wiley   +1 more source

Induction of Erythrocyte Shrinkage by Omeprazole

Dose-Response, 2020
Omeprazole, a proton pump inhibitor blocks the H + /K + -ATPase channels of gastric parietal cells. It is used for the treatment of peptic ulcer. Prolonged use of omeprazole may involve in inducing anemia.
Ayesha Naveed, Kashif Jilani, Abu Bakar Siddique, Muhammad Akbar, Muhammad Riaz, Zahid Mushtaq, Muhammad Sikandar, Sajida Ilyas, Ismat Bibi, Asma Asghar, Ghulam Rasool, Muhammad Irfan   +11 more
doaj   +1 more source

Triggering of Suicidal Erythrocyte Death by Celecoxib

Toxins, 2013
The selective cyclooxygenase-2 (COX-2) inhibitor celecoxib triggers apoptosis of tumor cells and is thus effective against malignancy. The substance is at least partially effective through mitochondrial depolarization.
Florian Lang, Kashif Jilani, Rosi Bissinger, Adrian Lupescu   +3 more
doaj   +1 more source

Enhanced Eryptosis Following Auranofin Exposure

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antiinflammatory, antimicrobial and anticancer drug auranofin has previously been shown to trigger apoptosis, the suicidal death of nucleated cells. Side effects of the drug include anaemia. At least in theory the anaemia could result from stimulation of suicidal death of erythrocytes or eryptosis, which involves cell shrinkage and
Kousi Alzoubi, Jasmin Egler, Majed Abed, Florian Lang   +3 more
openaire   +3 more sources

Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: The alkylphospholipid perifosine is used for the treatment of malignancy. The substance is effective by triggering suicidal tumor cell death or apoptosis. Side effects of perifosine include anemia. At least in theory, perifosine-induced anemia could result from stimulation of suicidal erythrocyte death or eryptosis.
Jasmin Egler, Florian Lang
openaire   +3 more sources

Dapsone‐Induced Heinz Body Hemolytic Anemia: A Case Report

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Patients who develop acute anemia, without evidence of blood loss, should have a hemolysis workup including a medication review in case this could be contributing. In our patient's case, workup was significant for Heinz body hemolytic anemia due to home dapsone. Patient's anemia ultimately resolved with drug cessation.
Tyler Edwards, Monica Montes‐Rivera, Lucy Fu   +2 more
wiley   +1 more source