Results 81 to 90 of about 1,400 (161)

Sensitization of Erythrocytes to Suicidal Erythrocyte Death Following Water Deprivation

Kidney & Blood Pressure Research, 2013
Background/Aims: Klotho deficiency results in excessive formation of 1,25(OH)2D3, accelerated ageing and early death. Moreover, klotho deficiency enhances eryptosis, the suicidal erythrocyte death characterized by phosphatidylserine exposure at the ...
Majed Abed, Martina Feger, Kousi Alzoubi, Tatsiana Pakladok, Leonie Frauenfeld, Corinna Geiger, Syeda T Towhid, Florian Lang   +7 more
doaj   +1 more source

Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review

ChemSystemsChem, Volume 7, Issue 1, January 2025.
We discuss the spatiotemporal patterns and nonequilibrium fluctuations of membranes, particularly on theoretical analyses and simulations. Protein active forces enhance or suppress the membrane fluctuations. Active binding/unbinding of proteins can induce traveling waves and Turing patterns accompanied by membrane deformation.
Hiroshi Noguchi
wiley   +1 more source

The Uremic Toxin Acrolein Promotes Suicidal Erythrocyte Death

Kidney & Blood Pressure Research, 2013
Background: Anemia is a major complication of end stage renal disease. The anemia is mainly the result of impaired formation of erythrocytes due to lack of erythropoietin and iron deficiency.
Mohamed Siyabeldin E. Ahmed, Henning Langer, Majed Abed, Jakob Voelkl, Florian Lang   +4 more
doaj   +1 more source

Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
Using carbon‐based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research as possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it ...
Santos-Adriana Martel-Estrada, Claudia-Lucía Vargas-Requena, Josue-Itan Sifuentes-Chavarría, Maileth-Yoelis Yepes-Mendoza, Daniel-Santiago Palacio-Castillo, Florinda Jimenez-Vega, Imelda Olivas-Armendáriz, Luis Jesús Villarreal-Gómez   +7 more
wiley   +1 more source

Stimulated Suicidal Erythrocyte Death in Arteritis

Cellular Physiology and Biochemistry, 2016
Background/Aims: Arteritis is an inflammatory disease of the vascular wall leading to ischemia and vascular occlusion. Complications of arteritis include anemia, which could, at least in theory, result from suicidal erythrocyte death or eryptosis, which ...
Rosi Bissinger, Daniela S. Kempe-Teufel, Sabina Honisch, Syed M. Qadri, Elko Randrianarisoa, Hans-Ulrich Häring, Jörg Henes, Florian Lang   +7 more
doaj   +1 more source

Prolonged Survival of Neutrophils Induced by Tumor‐Derived G‐CSF/GM‐CSF Promotes Immunosuppression and Progression in Laryngeal Squamous Cell Carcinoma

Advanced Science, Volume 11, Issue 46, December 11, 2024.
This study elucidates a novel mechanism whereby tumor‐derived G‐CSF and GM‐CSF induce delayed neutrophil apoptosis by activating the PI3K‐AKT signaling pathway. Delayed neutrophil apoptosis can facilitate the accumulation of immunosuppressive CXCR4+ neutrophils and impair CD8+ T cell immunity.
Xiaoke Zhu, Yu Heng, Jingyu Ma, Duo Zhang, Di Tang, Yangyang Ji, Changding He, Hanqing Lin, Xuping Ding, Jian Zhou, Lei Tao, Liming Lu   +11 more
wiley   +1 more source

Hypoxia‐Mimicking Mediated Macrophage‐Elimination of Erythrocytes Promotes Bone Regeneration via Regulating Integrin αvβ3/Fe2+‐Glycolysis‐Inflammation

Advanced Science, Volume 11, Issue 45, December 4, 2024.
Longstanding compacted erythrocytes impair bone regeneration. This study employs the hypoxia‐mimetic agent DMOG to enhance macrophage‐elimination of erythrocytes by up‐regulating integrin αvβ3. Increased phagocytosed erythrocytes regulate macrophage intracellular Fe2+‐glycolysis‐inflammation, creating a favorable bone regenerative microenvironment ...
Yong Ao, Yuanlong Guo, Yingye Zhang, Lv Xie, Ruidi Xia, Jieyun Xu, Mengru Shi, Xiaomeng Gao, Xiaoran Yu, Zetao Chen   +9 more
wiley   +1 more source

Effect of Thioridazine on Erythrocytes

Toxins, 2013
Background: Thioridazine, a neuroleptic phenothiazine with antimicrobial efficacy is known to trigger anemia. At least in theory, the anemia could result from stimulation of suicidal erythrocyte death or eryptosis, which is characterized by cell ...
Majed Abed, Florian Lang, Caterina Faggio, Markus Arnold, Rosi Bissinger, Elisabeth Lang, Paola Modicano   +6 more
doaj   +1 more source

Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A

Cellular Physiology and Biochemistry, 2016
Background/Aims: The serine/threonine protein phosphatase 1 and 2a inhibitor Calyculin A may trigger suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal erythrocyte death ...
Mustafa Almasry, Mohamed Jemaà, Morena Mischitelli, Caterina Faggio, Florian Lang   +4 more
doaj   +1 more source

Bile Acid-Induced Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: In nucleated cells, bile acids may activate cation channels subsequently leading to entry of Ca2+. In erythrocytes, increase of cytosolic Ca2+ activity triggers eryptosis, the suicidal death of erythrocytes characterized by ...
Elisabeth Lang, Vitaly I. Pozdeev, Sergios Gatidis, Syed M. Qadri, Dieter Häussinger, Ralf Kubitz, Diran Herebian, Ertan Mayatepek, Florian Lang, Karl S. Lang, Philipp A. Lang   +10 more
doaj   +1 more source