Results 91 to 100 of about 79,638 (253)

Altered brain lipid composition in cyclooxygenase-2 knockout mouse

Journal of Lipid Research, 2007
Cyclooxygenase (COX)-2 plays an important role in brain arachidonic acid (20:4n-6) metabolism, and its expression is upregulated in animal models of neuroinflammation and excitotoxicity. Our hypothesis was that brain lipid composition would be altered in
Kaizong Ma, Robert Langenbach, Stanley I. Rapoport, Mireille Basselin   +3 more
doaj   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes?

Open Biology
Calmodulin (CaM) is a ubiquitous calcium-sensitive messenger in eukaryotic cells. It was previously shown that CaM possesses an affinity for diverse lipid moieties, including those found on CaM-binding proteins. These facts, together with our observation
Federica Scollo, Carmelo Tempra, Hüseyin Evci, Miguel Riopedre-Fernandez, Agnieszka Olżyńska, Matti Javanainen, Arunima Uday, Marek Cebecauer, Lukasz Cwiklik, Hector Martinez-Seara, Pavel Jungwirth, Piotr Jurkiewicz, Martin Hof   +12 more
doaj   +1 more source

Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine [PDF]

, 2017
Blood coagulation involves activation of platelets and coagulation factors. At the interface of these two processes resides the lipid phosphatidylserine. Activated platelets expose phosphatidylserine on their outer membrane leaflet and activated clotting
Branchford, Brian R, Brown, Peter N, Peter N. Brown, Tamura, Ryo, White, Ormacinda R, Gary L. Brodsky, Brass, Lawrence F, Lawrence F. Brass, Yin, Hang, Jorge Di Paola, Noah Kastelowitz, Abimbola Onasoga, Hang Yin, Stalker, Timothy J, Ryo Tamura, Onasoga, Abimbola, Brian R. Branchford, Ormacinda R. White, Kastelowitz, Noah, Brodsky, Gary L, Timothy J. Stalker, Paola, Jorge Di   +21 more
core   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults – A Dose-Dependent Study

Journal of Pharmacy and Bioallied Sciences
Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health.
Sowjanya Lakkoju, Deepika Bolisetty, Ranjith Kumar   +2 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Triggering of Programmed Erythrocyte Death by Alantolactone

Toxins, 2014
The sesquiterpene alantolactone counteracts malignancy, an effect at least in part due to stimulation of suicidal death or apoptosis of tumor cells.
Kousi Alzoubi, Salvatrice Calabrò, Jasmin Egler, Caterina Faggio, Florian Lang   +4 more
doaj   +1 more source

Phosphatidylethanolamine positively regulates autophagy and longevity [PDF]

, 2015
This work was supported by the Austrian Science Fund FWF (grants LIPOTOX, I1000-B20, P23490-B12, and P24381-B20) to FM. The authors acknowledge support from NAWI Graz.
Pietrocola, F., Knittelfelder, O., O Knittelfelder, Franz, J, Pietrocola, F, Rockenfeller, Patrick, Carmona-Gutierrez, D., Madeo, F., Minois, N, Knittelfelder, O, J Franz, M Koska, Franz, J., Carmona-Gutierrez, D, G Kroemer, Madeo, F, Koska, M., Minois, N., Sica, V., Kroemer, G., F Pietrocola, Koska, M, D Carmona-Gutierrez, Kroemer, G, Rockenfeller, P, V Sica, F Madeo, N Minois, Rockenfeller, P., Sica, V, P Rockenfeller   +30 more
core   +1 more source

Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer

, 2018
Olivier Belzile,1 Xianming Huang,2,3 Jian Gong,2,3 Jay Carlson,2,3 Alan J Schroit,1 Rolf A Brekken,1 Bruce D Freimark2,3 1Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, 2Department of ...
Carlson J, Brekken RA, Belzile O, Huang X, Schroit AJ, Freimark BD, Gong J   +6 more
core