Results 61 to 70 of about 114,304 (186)

Stimulation of Erythrocyte Cell Membrane Scrambling by Mushroom Tyrosinase

Toxins, 2014
Background: Mushroom tyrosinase, a copper containing enzyme, modifies growth and survival of tumor cells. Mushroom tyrosinase may foster apoptosis, an effect in part due to interference with mitochondrial function.
Leonie Frauenfeld, Kousi Alzoubi, Majed Abed, Florian Lang   +3 more
doaj   +1 more source

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters [PDF]

, 2013
Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the plasma membrane that are essential for high-fidelity signal transmission. The lipid composition of Ras nanoclusters however has not previously been investigated.
Abankwa, Abankwa, Andresen, Ariotti, Baumgart, Brown, Brown, Casey, Cho, Deschout, Diggle, Dougherty, Epand, Garcia, Garg, Ghosh, Goldenberg, Gorfe, Gowrishankar, Grande-Garcia, Gutierrez, Hammond, Hancock, Hancock, Hancock, Hancock, Hill, Hong Liang, Jaumot, John F. Hancock, Kale, Kalwa, Kay, Kholodenko, Kiselev, Kiselev, Lee, Miao, Mor, Murakoshi, Nicholas Ariotti, Plowman, Plowman, Prior, Prior, Prior, Prior, Robert G. Parton, Rotblat, Roy, Schroeder, Sharma, Tian, Tian, Travis Rodkey, Treeck, van der Hoeven, van Rheenen, Veatch, Veatch, Voice, Yan, Yeung, Yong Zhou, Zeniou-Meyer, Zhou   +65 more
core   +1 more source

Aminoglycoside induces RIPOR2 translocation and phosphatidylserine externalization via distinct mechanisms

Frontiers in Cellular Neuroscience
Aminoglycosides are widely used to treat severe infections. However, systemically administered AGs preferentially kill cochlear hair cells, resulting in irreversible hearing loss. Recently, we found that AGs induce a rapid translocation of RIPOR2 in hair
Jinan Li, Michelle Yang, Bo Zhao, Bo Zhao, Bo Zhao   +4 more
doaj   +1 more source

Induction of Suicidal Erythrocyte Death by Cantharidin

Toxins, 2015
The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells,
Kousi Alzoubi, Jasmin Egler, Marilena Briglia, Antonella Fazio, Caterina Faggio, Florian Lang   +5 more
doaj   +1 more source

Altered brain lipid composition in cyclooxygenase-2 knockout mouse

Journal of Lipid Research, 2007
Cyclooxygenase (COX)-2 plays an important role in brain arachidonic acid (20:4n-6) metabolism, and its expression is upregulated in animal models of neuroinflammation and excitotoxicity. Our hypothesis was that brain lipid composition would be altered in
Kaizong Ma, Robert Langenbach, Stanley I. Rapoport, Mireille Basselin   +3 more
doaj   +1 more source

Engineered Fluorescent Variants of Lactadherin C2 Domain for Phosphatidylserine Detection in Flow Cytometry

Biomolecules
Phosphatidylserine (PS) is an essential phospholipid and an emerging biomarker involved in key biological processes. While annexin V (axV) is the most widely used tool for PS detection, its calcium-dependent binding and other limitations have spurred ...
Ekaterina Koltsova, Albina Avilova, Elena Nikolaeva, Nikita Kolchin, Kirill Butov   +4 more
doaj   +1 more source

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults – A Dose-Dependent Study

Journal of Pharmacy and Bioallied Sciences
Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health.
Sowjanya Lakkoju, Deepika Bolisetty, Ranjith Kumar   +2 more
doaj   +1 more source

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation [PDF]

, 2016
A dynamic, properly organised actin cytoskeleton is critical for the production and haemostatic function of platelets. The Wiskott Aldrich Syndrome protein (WASp) and Actin-Related Proteins 2 & 3 Complex (Arp2/3 complex) are critical mediators of ...
Bem, Danai, Finney, Brenda, Machesky, Laura M., Poulter, Natalie S., Thomas, Steven G., Watson, Stephen P.   +5 more
core   +4 more sources

Membrane Binding and Bending in Ebola VP40 Assembly and Egress

Frontiers in Microbiology, 2014
Lipid-enveloped viruses contain a lipid bilayer coat that protects their genome and helps to facilitate entry into the host cell. Filoviruses are lipid-enveloped viruses that have up to 90% clinical fatality and include Marbug (MARV) and Ebola (EBOV ...
Robert V Stahelin, Robert V Stahelin
doaj   +1 more source