Results 51 to 60 of about 78,278 (294)

Characterization of Phosphatidylserine Transport to the Locus of Phosphatidylserine Decarboxylase 2 in Permeabilized Yeast [PDF]

Journal of Biological Chemistry, 2001
In yeast, nascent phosphatidylserine (PtdSer) can be transported to the mitochondria and Golgi/vacuole for decarboxylation to synthesize phosphatidylethanolamine (PtdEtn). In strains with a psd1Delta allele for the mitochondrial PtdSer decarboxylase, the conversion of nascent PtdSer to PtdEtn can serve as an indicator of lipid transport to the locus of
W I, Wu, D R, Voelker
openaire   +2 more sources

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]

, 2010
Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Erck, C, Böttger, Angelika, Burrells Alison, Andreas Lengeling, Butler, Danica, Hahn, P., Erck, Christian, Wolf, A., Lengeling, A., Bottger, A., Jens Böse, Erck, C., Christopher J Schofield, Hahn, P, Wegener, Ivonne, Wegener Ivonne, Böse, Jens, Christian Erck, Angelika Böttger, Burrells, A, Ivonne Wegener, Butler, D, Butler Danica, Lengeling Andreas, Böse Jens, Burrells, A., Alexander Wolf, Hahn Phillip, Wolf, A, Bose, J., Lengeling, A, Erck Christian, Böttger Angelika, Danica Butler, Phillip Hahn, Butler, D., Wolf Alexander, Hahn, Phillip, Wolf, Alexander, Schofield, Christopher J, Alison Burrells, Schofield Christopher J., Böse, J, Lengeling, Andreas, Schofield, Christopher J., Wegener, I, Schofield, CJ, Wegener, I., Burrells, Alison, Schofield, Christopher, Böttger, A, Christopher J. Schofield   +51 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ANALYSIS OF PLASMA MEMBRANE INEGRITY BY USING OF FLUORESCEIN LABELED ANNEXIN V AND ITS RELATIONSHIP TO MOTILITY AND VIABILITY OF RAM SPERM AFTER CRYOPRESERVATION [PDF]

Journal of Central European Agriculture, 2006
The present study was conducted to detect sperm apoptosis in fresh, capacitated and frozen ram semen and to determine its relationship with other seminal parameters as motility and viability.
Maria IVANOVA-KICHEVA, Alexander DIMITROV, Ivan NIKOLOV, Denitza DASKALOVA, Malcho PETROV   +4 more
doaj  

Breakdown of Phospholipid Asymmetry Triggers ADAM17-Mediated Rescue Events in Cells Undergoing Apoptosis

Membranes, 2023
ADAM17, a prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through the cleavage of transmembrane substrates, including epidermal growth factor receptor (EGFR) ligands such as transforming growth
Maria Sperrhacke, Sinje Leitzke, Björn Ahrens, Karina Reiss   +3 more
doaj   +1 more source

Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo [PDF]

The Journal of Immunology, 2005
Abstract Phosphatidylserine (PS) on apoptotic cells promotes their uptake and induces anti-inflammatory responses in phagocytes, including TGF-β release. Little is known regarding the effects of PS on adaptive immune responses. We therefore investigated the effects of PS-containing liposomes on immune responses in mice in vivo.
Peter R, Hoffmann, Jennifer A, Kench, Andrea, Vondracek, Ellen, Kruk, David L, Daleke, Michael, Jordan, Philippa, Marrack, Peter M, Henson, Valerie A, Fadok   +8 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The effect of manipulating apoptotic cell uptake on their immunogenicity [PDF]

, 2009
Failure of the immune system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours.
Attfield, Kathrine Elizabeth
core   +1 more source

Engineered Fluorescent Variants of Lactadherin C2 Domain for Phosphatidylserine Detection in Flow Cytometry

Biomolecules
Phosphatidylserine (PS) is an essential phospholipid and an emerging biomarker involved in key biological processes. While annexin V (axV) is the most widely used tool for PS detection, its calcium-dependent binding and other limitations have spurred ...
Ekaterina Koltsova, Albina Avilova, Elena Nikolaeva, Nikita Kolchin, Kirill Butov   +4 more
doaj   +1 more source

Expression of phosphatidylserine (PS) on wild-type and Gerbich variant erythrocytes following glycophorin-C (GPC) ligation

, 2005
Glycophorin-C (GPC) is a 40 kDa glycoprotein expressed on erythrocytes and is a receptor for the malarial parasite Plasmodium falciparum to invade these cells.
Lee, Zoe E., Head, David J., Poole, Joyce, Avent, Neil D.   +3 more
core   +1 more source