Results 41 to 50 of about 79,638 (253)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Research Progress on Preparation Method, Structure and Application of Phosphatidylserine Liposomes

Shipin gongye ke-ji
Phosphatidylserine is an important cell membrane component, especially in animal brain nerve cells. It has many biological activities such as improving nerve cell function, regulating nerve impulse conduction and enhancing memory.
Feilong SHI, Fangbing WU, Jiayan WANG, Yu PAN, Yao ZHANG, Chengxiang AO, Yuanyong TIAN, Xuefeng LU, Hui ZHAO, Hang LU   +9 more
doaj   +1 more source

Action of the highly purified, membrane-bound enzyme phosphatidylserine decarboxylase Escherichia coli toward phosphatidylserine in mixed micelles and erythrocyte ghosts in the presence of surfactant. [PDF]

, 1975
Phosphatidylserine decarboxylase, Escheichia coli, was purified to near-homogeneity by the procedure of Dowhan, W., Wickner, W. T., and Kennedy, E. P. ((1974) J. Biol. Chem.
Warner, TG, Dennis, EA, TG Warner, EA Dennis   +3 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Physiological consequences of disruption of mammalian phospholipid biosynthetic genes

Journal of Lipid Research, 2009
By 1959, Eugene Kennedy and coworkers had outlined most pathways of phospholipid biosynthesis. In the next four decades, the emphasis was on enzymology and regulation of these pathways.
Dennis E. Vance, Jean E. Vance
doaj   +1 more source

Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis [PDF]

, 2021
Prostate and breast cancer are the current leading causes of new cancer cases in males and females, respectively. Phosphatidylserine (PS) is an essential lipid that mediates macrophage efferocytosis and is dysregulated in tumors.
Allan Radaic, Nicholas Kotov, Nam E. Joo, Soo-Hwan Jeong, Yvonne L. Kapila, Jeong, Soo-Hwan, Kapila, Yvonne L, Seong-II Yoo, Yoo, Seong-II, Kotov, Nicholas, Joo, Nam E, Radaic, Allan   +11 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

ANALYSIS OF PLASMA MEMBRANE INEGRITY BY USING OF FLUORESCEIN LABELED ANNEXIN V AND ITS RELATIONSHIP TO MOTILITY AND VIABILITY OF RAM SPERM AFTER CRYOPRESERVATION [PDF]

Journal of Central European Agriculture, 2006
The present study was conducted to detect sperm apoptosis in fresh, capacitated and frozen ram semen and to determine its relationship with other seminal parameters as motility and viability.
Maria IVANOVA-KICHEVA, Alexander DIMITROV, Ivan NIKOLOV, Denitza DASKALOVA, Malcho PETROV   +4 more
doaj  

Breakdown of Phospholipid Asymmetry Triggers ADAM17-Mediated Rescue Events in Cells Undergoing Apoptosis

Membranes, 2023
ADAM17, a prominent member of the “Disintegrin and Metalloproteinase” (ADAM) family, controls vital cellular functions through the cleavage of transmembrane substrates, including epidermal growth factor receptor (EGFR) ligands such as transforming growth
Maria Sperrhacke, Sinje Leitzke, Björn Ahrens, Karina Reiss   +3 more
doaj   +1 more source

Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome [PDF]

, 2013
Lenz-Majewski syndrome (LMS) is a syndrome of intellectual disability and multiple congenital anomalies that features generalized craniotubular hyperostosis. By using whole-exome sequencing and selecting variants consistent with the predicted dominant de
Chrzanowska, K, Estelle Chanudet, Jorge M Saraiva, Gudrun E Moore, Vance, JE, Moore, GE, Wattanasirichaigoon, D, Lionel Van Maldergem, Beales, PL, Barnicoat, A, Glenn Anderson, Duangrurdee Wattanasirichaigoon, Calder, A, Tasseva, G, Sá, J, Joaquim Sa, Philip Stanier, Mina Ryten, Martina Simandlová, Philip L Beales, Alistair Calder, Jenkins, D, Ishida, M, Guergana Tasseva, Krystyna Chrzanowska, Anderson, G, Chanudet, E, Angela Barnicoat, Dagan Jenkins, Docker, J, Ryten, M, Sérgio B Sousa, Richard Scott, Simandlová, M, Miho Ishida, Scott, R, Saraiva, JM, James Docker, Stanier, P, Jean E Vance, Sousa, SB, Van Maldergem, L   +41 more
core   +1 more source