Results 21 to 30 of about 79,638 (253)

Nanoscopic Spatial Association between Ras and Phosphatidylserine on the Cell Membrane Studied with Multicolor Super Resolution Microscopy

Biomolecules, 2022
Recent work suggests that Ras small GTPases interact with the anionic lipid phosphatidylserine (PS) in an isoform-specific manner, with direct implications for their biological functions.
Anna M. Koester, Kai Tao, Malwina Szczepaniak, Matthew J. Rames, Xiaolin Nan   +4 more
doaj   +1 more source

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells [PDF]

, 2017
We have discovered that a small cationic molecule, GW4869, is cytotoxic to a subset of myeloma cell lines and primary myeloma plasma cells. Biochemical analysis revealed that GW4869 binds to anionic phospholipids such as phosphatidylserine - a lipid ...
Paul Ramsland (12471351), Slavica Vuckovic (7121114), Kate Vandyke (3535730), David Rickards (20049768)   +3 more
core   +2 more sources

Tim-4 in Health and Disease: Friend or Foe?

Frontiers in Immunology, 2020
T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is a phosphatidylserine receptor and is selectively expressed on antigen presenting cells. Recently, Tim-4 was reported to be expressed on iNKT cells, B1 cells, and tumor cells, suggesting it ...
Wen Liu, Liyun Xu, Liyun Xu, Xiaohong Liang, Xiaojun Liu, Yangbing Zhao, Yangbing Zhao, Chunhong Ma, Lifen Gao   +8 more
doaj   +1 more source

Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and atherosclerosis

, 2021
Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and ...
Shiva Ganjali (14682088), A Kontush (18985775), A Sahebkar (7797281), MR Jaafari (18985778), AA Momtazi-Borojeni (18985772), MB Naeini (18985769)   +5 more
core  

Fluoxetine Induced Suicidal Erythrocyte Death

Toxins, 2013
The antidepressant fluoxetine inhibits ceramide producing acid sphingomyelinase. Ceramide is in turn known to trigger eryptosis the suicidal death of erythrocytes characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte ...
Florian Lang, Majed Abed, Ahmad Almilaji, Rosi Bissinger, Sigrid Enkel, Kashif Jilani   +5 more
doaj   +1 more source

Importance of Efferocytosis in COVID-19 Mortality

Infection and Drug Resistance, 2022
Adnan Erol Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, TurkeyCorrespondence: Adnan Erol, Independent Researcher, Not Affiliated to Any Institution, Silivri-Istanbul, Turkey, Email eroladnan@protonmail.comAbstract: COVID ...
Erol A
doaj  

Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite

Journal of Lipid Research, 2018
The malaria parasite, Plasmodium falciparum, develops and multiplies in the human erythrocyte. It needs to synthesize considerable amounts of phospholipids (PLs), principally phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine
Sharon Wein, Salma Ghezal, Corinne Buré, Marjorie Maynadier, Christian Périgaud, Henri J. Vial, Isabelle Lefebvre-Tournier, Kai Wengelnik, Rachel Cerdan   +8 more
doaj   +1 more source

Tumor-Associated Exosomes: A Potential Therapeutic Target for Restoring Anti-Tumor T Cell Responses in Human Tumor Microenvironments

Cells, 2021
Exosomes are a subset of extracellular vesicles (EVs) that are released by cells and play a variety of physiological roles including regulation of the immune system. Exosomes are heterogeneous and present in vast numbers in tumor microenvironments.
Gautam N. Shenoy, Maulasri Bhatta, Richard B. Bankert   +2 more
doaj   +1 more source

Phosphatidylserine in atherosclerosis

, 2016
International audiencePurpose of review: It is now widely acknowledged that phosphatidylserine is a multifunctional bioactive lipid. In this review, we focus on the function of phosphatidylserine in modulating cholesterol metabolism, influencing ...
Darabi, Maryam, Kontush, Anatol
core   +1 more source

Membrane Binding and Bending in Ebola VP40 Assembly and Egress

Frontiers in Microbiology, 2014
Lipid-enveloped viruses contain a lipid bilayer coat that protects their genome and helps to facilitate entry into the host cell. Filoviruses are lipid-enveloped viruses that have up to 90% clinical fatality and include Marbug (MARV) and Ebola (EBOV ...
Robert V Stahelin, Robert V Stahelin
doaj   +1 more source