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Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines [PDF]

Frontiers in Medical Technology, 2023
IntroductionCochleates are cylindrical particles composed of dehydrated phospholipid bilayers. They are typically prepared by addition of calcium ions to vesicles composed of negatively charged phospholipids such as phosphatidylserines (PS). Due to their
Judith Kuntsche
exaly   +4 more sources

Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis [PDF]

Journal of Molecular and Cellular Cardiology Plus
Objectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantation (TAVI).
Kyriakos Panaou, Constantijn S. Venema, Kees H. van Bergeijk, Demetra Hadjicharalambous, Nicolas Girerd, Teresa Trenkwalder, Michael Joner, Pim van der Harst, Jasper Tromp, Adriaan A. Voors, Joanna J. Wykrzykowska   +10 more
doaj   +2 more sources

Diannexin Protects against Renal Ischemia Reperfusion Injury and Targets Phosphatidylserines in Ischemic Tissue [PDF]

PLoS ONE, 2011
Renal ischemia/reperfusion injury (IRI) frequently complicates shock, renal transplantation and cardiac and aortic surgery, and has prognostic significance. The translocation of phosphatidylserines to cell surfaces is an important pro-inflammatory signal
Otto Boerman, Rosalinde Masereeuw, Gérard Rongen   +2 more
exaly   +2 more sources

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

PLoS Pathogens, 2018
Herpes simplex virus (HSV) entry is associated with Akt translocation to the outer leaflet of the plasma membrane to promote a complex signaling cascade.
Carl Pierce, Betsy Herold
exaly   +2 more sources

Ether Phosphatidylserine from Soft Coral Sclerophytum heterospiculatum Reveals Antioxidant Activity and Modulates Lipid Composition in LPS-Activated Human Microglial HMC-3 Cells [PDF]

Marine Drugs
Ether phospholipids from marine organisms represent an understudied class of bioactive lipids with unique structural features. In this study, we isolated, for the first time, an ether phosphatidylserine (ePS) species from the soft coral Sclerophytum ...
Elena T. Bizikashvili, Arina I. Ponomarenko, Ekaterina V. Ermolenko, Igor V. Manzhulo   +3 more
doaj   +2 more sources

Plasma Membrane Lipid Composition and Turnover in Human Midbrain Neurons Investigated by Time-of-Flight Mass Spectrometry [PDF]

Biomolecules
The molecular structure and dynamics of the neuronal plasma membrane are essential for neuronal biology and function. We employed time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging to investigate the lipid composition and turnover at the ...
Emmanuel Berlin, Alicia A. Lork, Carl Ernst, John S. Fletcher, Nhu T. N. Phan   +4 more
doaj   +2 more sources

Plasma Lipidomic Alterations in Fontan Circulation Reflect Cardiovascular Functional Reserve [PDF]

Metabolites
Background: Fontan circulation is associated with impaired cardiac output, reduced exercise capacity, and systemic metabolic stress. However, the underlying lipidomic alterations remain poorly defined.
Arun Surendran, Amir Ravandi, Ashish H. Shah   +2 more
doaj   +2 more sources

Lipid Composition of Camel Milk and Cow Milk in Xinjiang Province of China Analyzed by Method of Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (UPLC-Q-TOF-MS) [PDF]

Food Science of Animal Resources
Xinjiang province is the main dairy production area of China, and Junggar Bactrian camel usually lived in the north part. Lipid is the main nutrient component of milk, and there is few reports about the differences in lipids between camel milk and cow ...
Jing Miao, Jun Wang
doaj   +2 more sources

Metabolomic atlas of dengue virus infection reveals distinct circulating bioactive lipid signatures. [PDF]

PLoS Neglected Tropical Diseases
Dengue virus (DENV) appears to manipulate several cellular metabolic pathways to permit its replication and immune evasion in the host. Here, we employed high-resolution mass spectrometry (HR-MS) to investigate the serum metabolomic landscape of clinical
Abdul R Anshad, Muthuvel Atchaya, Shanmugam Saravanan, Amudhan Murugesan, Siyana Fathima, Ethihas R Mahasamudram, Rajendran Kannan, Marie Larsson, Esaki M Shankar   +8 more
doaj   +2 more sources

A Japanese Case of Lenz‐Majewski Syndrome With a Novel PTDSS1 Variant [PDF]

Molecular Genetics & Genomic Medicine
Background Lenz‐Majewski syndrome (LMS) is a rare genetic disorder characterized by osteosclerosis, intellectual disability, characteristic facies, and distinct craniofacial, dental, cutaneous, and distal‐limb anomalies.
Yasuko Kobari, Non Miyata, Jun Takayama, Naoya Saijo, Tomohisa Suzuki, Shigeo Kure, Atsuo Kikuchi, Gen Tamiya, Takumi Takizawa   +8 more
doaj   +2 more sources