Results 21 to 30 of about 31,210 (332)

Differential activation of protein kinase C isozymes by short chain phosphatidylserines and phosphatidylcholines.

Journal of Biological Chemistry, 1990
To investigate the importance of the physical state of phospholipids for activation of protein kinase C, we have used short chain phospholipids, which, depending on their concentration, can exist as either monomers or micelles.
J J Sando
exaly   +2 more sources

Multi-Omic Characterization of Epithelial–Mesenchymal Transition: Lipidomic and Metabolomic Profiles as Key Markers of TGF-β-Induced Transition in Huh7 Hepatocellular Carcinoma [PDF]

Cells
Epithelial–mesenchymal transition (EMT) is a key process in cancer progression and fibrogenesis. In this study, EMT was induced in Huh7 hepatocellular carcinoma cells via TGF-β1 treatment, and the resulting lipidomic and metabolomic alterations were ...
Agnese Bertoldi, Gaia Cusumano, Eleonora Calzoni, Husam B. R. Alabed, Roberto Maria Pellegrino, Sandra Buratta, Lorena Urbanelli, Carla Emiliani   +7 more
doaj   +2 more sources

Metabolomic atlas of dengue virus infection reveals distinct circulating bioactive lipid signatures. [PDF]

PLoS Neglected Tropical Diseases
Dengue virus (DENV) appears to manipulate several cellular metabolic pathways to permit its replication and immune evasion in the host. Here, we employed high-resolution mass spectrometry (HR-MS) to investigate the serum metabolomic landscape of clinical
Abdul R Anshad, Muthuvel Atchaya, Shanmugam Saravanan, Amudhan Murugesan, Siyana Fathima, Ethihas R Mahasamudram, Rajendran Kannan, Marie Larsson, Esaki M Shankar   +8 more
doaj   +2 more sources

A Japanese Case of Lenz‐Majewski Syndrome With a Novel PTDSS1 Variant [PDF]

Molecular Genetics & Genomic Medicine
Background Lenz‐Majewski syndrome (LMS) is a rare genetic disorder characterized by osteosclerosis, intellectual disability, characteristic facies, and distinct craniofacial, dental, cutaneous, and distal‐limb anomalies.
Yasuko Kobari, Non Miyata, Jun Takayama, Naoya Saijo, Tomohisa Suzuki, Shigeo Kure, Atsuo Kikuchi, Gen Tamiya, Takumi Takizawa   +8 more
doaj   +2 more sources

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2

Cell Death and Differentiation, 2014
Krishnakumar Balasubramanian, Anna S Vikulina, Rong-Rong He   +2 more
exaly   +2 more sources

Variations in the milk lipidomic profile of lactating dairy cows fed the diets containing alfalfa hay versus alfalfa silage [PDF]

Animal Nutrition
Alfalfa is primarily stored as silage or hay in livestock production. Previous research has shown that the storage method of grass significantly influences milk composition.
Kaizhen Liu, Meiqing Chen, Guoxin Huang, Chuanyou Su, Wenhao Tang, Ning Li, Jiyong Yang, Xufang Wu, Boxue Si, Shengguo Zhao, Nan Zheng, Yangdong Zhang, Jiaqi Wang   +12 more
doaj   +2 more sources

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein

Biomolecules, 2021
The lipid composition of biomembranes influences the properties of the lipid bilayer and that of the proteins. In this study, the lipidome and the lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein was ...
Maria João Moreno, Patrícia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar   +4 more
doaj   +1 more source

Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

Metabolites, 2022
(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases.
Jianping Xu, Kaiyi Zhang, Bintao Qiu, Jieying Liu, Xiaoyu Liu, Shulin Yang, Xinhua Xiao   +6 more
doaj   +1 more source

Plasma procoagulant phospholipid clotting time and venous thromboembolism risk

Research and Practice in Thrombosis and Haemostasis, 2021
Background Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles.
Cathrine Ramberg, Line Wilsgård, Nadezhda Latysheva, Sigrid K. Brækkan, Kristian Hindberg, Timofey Sovershaev, Omri Snir, John‐Bjarne Hansen   +7 more
doaj   +1 more source

Fumonisin B Series Mycotoxins’ Dose Dependent Effects on the Porcine Hepatic and Pulmonary Phospholipidome

Toxins, 2022
Male weaned piglets n = 6/group were fed Fumonisin B1+2+3 (FBs) mycotoxins at 0, 15, or 30 mg/kg diet for 3 weeks to assess the fatty acid (FA) composition of membrane lipid classes, lipid peroxidation, and histomorphological changes in the liver and ...
Omeralfaroug Ali, Miklós Mézes, Krisztián Balogh, Melinda Kovács, Janka Turbók, András Szabó   +5 more
doaj   +1 more source