Results 11 to 20 of about 31,210 (332)

Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines [PDF]

Frontiers in Medical Technology, 2023
IntroductionCochleates are cylindrical particles composed of dehydrated phospholipid bilayers. They are typically prepared by addition of calcium ions to vesicles composed of negatively charged phospholipids such as phosphatidylserines (PS). Due to their
Søren Kristensen, Khadeija Hassan, Nadia Skarnager Andersen, Frank Steiniger, Judith Kuntsche   +4 more
exaly   +5 more sources

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

PLoS Pathogens, 2018
Herpes simplex virus (HSV) entry is associated with Akt translocation to the outer leaflet of the plasma membrane to promote a complex signaling cascade.
Carl Pierce, Betsy C Herold
exaly   +3 more sources

Diannexin Protects against Renal Ischemia Reperfusion Injury and Targets Phosphatidylserines in Ischemic Tissue [PDF]

PLoS ONE, 2011
Renal ischemia/reperfusion injury (IRI) frequently complicates shock, renal transplantation and cardiac and aortic surgery, and has prognostic significance. The translocation of phosphatidylserines to cell surfaces is an important pro-inflammatory signal
Kimberley E Wever, Frank A D T G Wagener, Cathelijne Frielink   +2 more
exaly   +3 more sources

Calorimetric and Spectroscopic Studies of the Thermotropic Phase Behavior of Lipid Bilayer Model Membranes Composed of a Homologous Series of Linear Saturated Phosphatidylserines

Biophysical Journal, 2000
The thermotropic phase behavior of lipid bilayer model membranes composed of the even-numbered, N-saturated 1,2-diacyl phosphatidylserines was studied by differential scanning calorimetry and by Fourier-transform infrared and (31)P-nuclear magnetic ...
Ruthven N A H Lewis, Ronald N McElhaney
exaly   +2 more sources

Regional Loss of the Mitochondrial Membrane Potential in the Hepatocyte Is Rapidly Followed by Externalization of Phosphatidylserines at That Specific Site during Apoptosis

Journal of Biological Chemistry, 2003
The spatio-temporal relationship between a decrease in the mitochondrial membrane potential (MMP) and externalization of phosphatidylserines (PS) during induction of apoptosis was investigated in single freshly isolated hepatocytes. Apoptosis was induced
W Marty Blom, Hans J G M De Bont, J Fred Nagelkerke   +2 more
exaly   +2 more sources

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Cell Reports, 2017
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with ...
Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Janine Prange-Kiel, Catherine R. Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A. Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L. White, III, Joachim Herz   +13 more
doaj   +2 more sources

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017
Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown.
Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A. Kiebish, Laurie J. Goodyear, Kristin I. Stanford   +12 more
doaj   +2 more sources

Methyl carbamates of phosphatidylethanolamines and phosphatidylserines reveal bacterial contamination in mitochondrial lipid extracts of mouse embryonic fibroblasts [PDF]

Scientific Reports, 2023
The occurrence of methyl carbamates of phosphatidylethanolamines and phosphatidylserines in the lipid extract of mitochondria obtained from mouse embryonic fibroblasts was ascertained by hydrophilic interaction liquid chromatography with electrospray ...
Andrea Castellaneta, Vito Porcelli, Ilario Losito, Serena Barile, Alessandra Maresca, Valentina Del Dotto, Ludovica Sofia Guadalupi, Cosima Damiana Calvano, Valerio Carelli, Luigi Palmieri, Tommaso R. I. Cataldi   +10 more
doaj   +2 more sources

Plasma Membrane Lipid Composition and Turnover in Human Midbrain Neurons Investigated by Time-of-Flight Mass Spectrometry [PDF]

Biomolecules
The molecular structure and dynamics of the neuronal plasma membrane are essential for neuronal biology and function. We employed time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging to investigate the lipid composition and turnover at the ...
Emmanuel Berlin, Alicia A. Lork, Carl Ernst, John S. Fletcher, Nhu T. N. Phan   +4 more
doaj   +2 more sources

Plasma Lipidomic Alterations in Fontan Circulation Reflect Cardiovascular Functional Reserve [PDF]

Metabolites
Background: Fontan circulation is associated with impaired cardiac output, reduced exercise capacity, and systemic metabolic stress. However, the underlying lipidomic alterations remain poorly defined.
Arun Surendran, Amir Ravandi, Ashish H. Shah   +2 more
doaj   +2 more sources