Results 41 to 50 of about 466 (146)

Phosphatidylserine hide-and-seek [PDF]

Proceedings of the National Academy of Sciences, 2018
Every day, billions of new cells are produced in our bodies, and an equivalent number must die. Normally this occurs by apoptosis (1), during which the chromatin compacts against the nuclear envelope, followed rapidly by nuclear fragmentation and budding into multiple membrane-bound apoptotic bodies. This “dance of death” results from the activation of
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Control of phosphatidylserine biosynthesis through phosphatidylserine-mediated inhibition of phosphatidylserine synthase I in Chinese hamster ovary cells [PDF]

Proceedings of the National Academy of Sciences, 1998
Phosphatidylserine (PtdSer) synthesis in Chinese hamster ovary (CHO) cells occurs through the exchange of l -serine with the base moiety of phosphatidylcholine or phosphatidylethanolamine. The synthesis is depressed on the addition of PtdSer to the culture medium.
O, Kuge, K, Hasegawa, K, Saito, M, Nishijima   +3 more
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Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics

Frontiers in Pharmacology, 2022
This study aimed to investigate the effects and underlying mechanisms of tormentic acid (TA) on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
Xing Lin, Yuanyuan Wei, Yan Li, Yuhua Xiong, Bin Fang, Cuiyu Li, Quanfang Huang, Renbin Huang, Jinbin Wei   +8 more
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Characterization of Phosphatidylserine Transport to the Locus of Phosphatidylserine Decarboxylase 2 in Permeabilized Yeast [PDF]

Journal of Biological Chemistry, 2001
In yeast, nascent phosphatidylserine (PtdSer) can be transported to the mitochondria and Golgi/vacuole for decarboxylation to synthesize phosphatidylethanolamine (PtdEtn). In strains with a psd1Delta allele for the mitochondrial PtdSer decarboxylase, the conversion of nascent PtdSer to PtdEtn can serve as an indicator of lipid transport to the locus of
W I, Wu, D R, Voelker
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Electrochemical regulation of budding yeast polarity.

PLoS Biology, 2014
Cells are naturally surrounded by organized electrical signals in the form of local ion fluxes, membrane potential, and electric fields (EFs) at their surface.
Armin Haupt, Alexis Campetelli, Daria Bonazzi, Matthieu Piel, Fred Chang, Nicolas Minc   +5 more
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Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo [PDF]

The Journal of Immunology, 2005
Abstract Phosphatidylserine (PS) on apoptotic cells promotes their uptake and induces anti-inflammatory responses in phagocytes, including TGF-β release. Little is known regarding the effects of PS on adaptive immune responses. We therefore investigated the effects of PS-containing liposomes on immune responses in mice in vivo.
Peter R, Hoffmann, Jennifer A, Kench, Andrea, Vondracek, Ellen, Kruk, David L, Daleke, Michael, Jordan, Philippa, Marrack, Peter M, Henson, Valerie A, Fadok   +8 more
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Role of a serum phospholipase A1 in the phosphatidylserine-induced T cell inhibition [PDF]

, 1993
We have previously shown that unsaturated phosphatidylserines inhibit mitogen-induced T cell activation. We now report that the inhibitory action requires a protein present in bovine and human serum. Partial purification and phospholipase assay show that
Alessandro Bruni, Fabrizio Bellini, Bruni, Alessandro, Bellini, Fabrizio   +3 more
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In vitro Evaluation of Cytarabin Induced Apoptosis in Leukemic Blasts

Iranian Journal of Allergy, Asthma and Immunology, 2005
Apoptosis, or active cell death, is a specific mode of cell death, which is characterized by morphological changes such as chromatin condensation, fragmentation of the nucleus, cytoplasmic retraction and appearance of apoptotic bodies' containing ...
Tahereh Zieh, Asghar Safarifard, Mahin Nikogoftar   +2 more
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Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis

Journal of Molecular and Cellular Cardiology Plus
Objectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantation (TAVI).
Kyriakos Panaou, Constantijn S. Venema, Kees H. van Bergeijk, Demetra Hadjicharalambous, Nicolas Girerd, Teresa Trenkwalder, Michael Joner, Pim van der Harst, Jasper Tromp, Adriaan A. Voors, Joanna J. Wykrzykowska   +10 more
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A141

EJC Supplements, 2015
The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels.
H. Davtyan, G. Hakobyan, K. Alexsanyan, Y. Tadevosyan   +3 more
doaj   +1 more source