Results 61 to 70 of about 31,210 (332)

Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet

Journal of Lipid Research, 2021
Recent studies have highlighted an important role for lysophosphatidylcholine acyltransferase 3 (LPCAT3) in controlling the PUFA composition of cell membranes in the liver and intestine.
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlène Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Hélène Choubley, Loïc Mazzeo, Louise Menegaut, Lorène Josiane Lebrun, Kévin Van Dongen, Marion Xolin, Tony Jourdan, Chloé Buch, Jérome Labbé, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober   +20 more
doaj   +1 more source

Simple Model of the Transduction of Cell-Penetrating Peptides

, 2010
Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction.
Andrews, Bevers, Chen, Datta, Dom, Duchardt, Fischer, Frankel, Grandmaison, Green, Haase, Harbour, Herce, Hosotani, Jiang, K. Cahill, Kuge, Lipinski, Mai, Melikov, Mendoza, O'Shaughnessy, Parsegian, Prochiantz, Rostovtseva, Rothbard, Rothbard, Saito, Snyder, Snyder, Stone, Tang, Tünnemann, Tünnemann, Tünnemann, Tyagi, Voelker, Wadia, Willam, Zhou, Ziegler   +40 more
core   +1 more source

Increased levels of circulating Annexin A5 in Familial Mediterranean fever [PDF]

, 2010
Background Familial Mediterranean fever is a genetic autoinflammatory disease most commonly affecting the ethnic groups originating from around the Mediterranean Sea.
Anna S Boyajyan, Gohar M Mkrtchyan, Lilit P Hovhannisyan, Tigran J Hovsepyan   +3 more
core   +1 more source

Molecular Electroporation and the Transduction of Oligoarginines

, 2009
Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis.
Alberts B, Alberts B, Alberts B, Alberts B, Alberts B, Bevers E, Bulte J W, Cahill K, Datta K, Grandmaison P A, Hanke M, Harbour J W, Hosotani R, Kevin Cahill, Kuge O, Mai J C, Mendoza N, Vaara M, Vance J E, Voelker D, Vondrášek J   +20 more
core   +1 more source

On the coordination of La3+ by phosphatidylserine

Biophysical Journal, 1989
In a recent study by Bentz, J., D. Alford, J. Cohen, and N. Düzgünes (1988. Biophys. J. 53:593-607), La3+ was found to be more effective than Ca2+ in causing nonleaky fusion of phosphatidylserine vesicles. It was proposed that this difference in fusion efficiency may be due, in part, to a difference in coordination of the two cations. That is, Ca2+ was
Petersheim, M., Sun, J.
openaire   +2 more sources

Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Lipids in Health and Disease, 2022
Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative diseases ...
Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri   +6 more
doaj   +1 more source

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide [PDF]

, 2016
Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs.
Avery, Vicky M., Baell, Jonathan B., Creek, Darren J., Ellis, Katherine M., Ferrins, Lori, Jones, Amy J., McConville, Malcolm J., Nowell, Cameron J., Rahmani, Raphael, Read, Kevin D., Riley, Jennifer, Stoessel, Daniel   +11 more
core   +2 more sources

Lipid composition of the cancer cell membrane

Journal of Bioenergetics and Biomembranes, 2020
Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition ...
W. Szlasa, Iga Zendran, Aleksandra Zalesińska, M. Tarek, J. Kulbacka   +4 more
semanticscholar   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]

, 2019
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G, He, Cuiwen, Heizer, Patrick J, Hu, Xuchen, Jiang, Haibo, Jung, Rachel S, Tontonoz, Peter, Tu, Yiping, Weston, Thomas A, Wohlschlegel, James A, Young, Brian D, Young, Stephen G   +11 more
core   +3 more sources