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Phosphatidylserine in Diabetes Research

Molecular Pharmaceutics, 2022
Phospholipids are lipids that constitute the basic structure of cell membranes. In-depth research has shown that in addition to supporting cell structures, phospholipids participate in multiple cellular processes, including promoting cell signal transduction, guiding protein translocation, activating enzymatic activity, and eliminating dysfunctional ...
Dandan Xiao, Wenguang Chang
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Preparation of Phosphatidylserine

Nature, 1963
SEVERAL methods for the preparation1,2 or quantitative isolation3 of phosphatidylserine are now in existence. An investigation of some of the factors involved in the chromatography of phospholipids4,5 revealed the role of H+ ion exchange in the conversion of the salt form to the acidic form of phosphatidylserine on a silicic acid column.
L. Rathbone, P. M. Maroney
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Phosphatidylserine and the human brain

Nutrition, 2015
The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function.A scientific literature search was conducted on MEDLINE for relevant articles regarding PS and the human brain published before June 2014. Additional publications
Kyl Smith, Michael J. Glade
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Phosphatidylserine for the Athlete

Strength & Conditioning Journal, 2015
POSITIVE ADAPTATIONS FROM TRAINING ONLY OCCUR WHEN RESTORATION EXCEEDS THE CATABOLIC DOSAGE RECEIVED DURING TRAINING. NUMEROUS FACTORS AFFECT RECOVERY, SUCH AS ADDITIONAL LIFE STRESS. THE CUMULATIVE STRESS CAN NEGATIVELY AFFECT RESTORATION, AS WELL AS PERFORMANCE.
Mike Greenwood, Jeremy G Carter
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Optimized synthesis of phosphatidylserine

Amino Acids, 2010
The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting ...
GUANTI, GIUSEPPE   +6 more
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Induction of Apoptosis by Phosphatidylserine

Journal of Biochemistry, 1998
Treatment of Chinese hamster ovary (CHO) cells with phosphatidylserine (PS) caused cell death in a dose-dependent manner. Other phospholipids, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid, had no effect on cell viability. The cells incubated with PS became round and underwent a dramatic reduction of
Kayoko Uchida   +4 more
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Metabolism and functions of phosphatidylserine

Progress in Lipid Research, 2005
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss the available information on the regulation of PS biosynthesis in these organisms ...
Rineke Steenbergen, Jean E. Vance
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Phosphatidylserine decarboxylase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes. The cloned bacterial gene encodes an integral membrane protein that is first made as a proenzyme, and subsequently proteolyzed to an alpha subunit, containing a pyruvoyl prosthetic group, and a beta subunit. Two
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