Results 141 to 150 of about 76,679 (335)

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

open access: yesAdvanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer   +8 more
wiley   +1 more source

Palladium‐Catalyzed Gem‐Diborylalkylation of Silyl Enol Ethers and N‐Vinylacetamide via Diboryl Carbon‐Centered Radicals

open access: yesAdvanced Science, EarlyView.
Unlocking new reactivity: a palladium‐catalyzed coupling of gem‐iododiborylalkanes with electron‐rich olefins enables streamlined access to β,β‐diboryl carbonyl compounds under mild conditions. Mechanistic insights reveal a Pd(0)/Pd(I) cycle and a diboryl‐stabilized radical intermediate, offering a distinct platform for advancing unconventional ...
Xiao‐Yu Xie   +4 more
wiley   +1 more source

Synthesis of Diaryl‐ and Dialkynylphosphinates From Ubiquitous PV Sources via a Redox‐Neutral Approach

open access: yesAdvanced Science, EarlyView.
Classical strategies for P─C bond formation rely on precursors (e.g., PH3, H2PO2, PCl3) obtained from P4, which is produced via the energy‐intensive thermal process. Here, an alternative, redox‐neutral approach is explored. Primary phosphate sources are activated with triflic anhydride (Tf2O) and 4‐dimethylaminopyridine (DMAP) to a versatile PV ...
Tobias Schneider   +5 more
wiley   +1 more source

Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene

open access: yesAdvanced Science, EarlyView.
A remarkable dual‐ligand strategy is employed in Rh‐catalyzed sequential coupling reaction of dinucleophiles and 1,3‐enynes with high regio‐ and chemo‐selectivity. Abstract Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei   +4 more
wiley   +1 more source

Poisoning with Phosphine Gas Result the Rice Tablet, Report of Two Cases

open access: yesپزشکی بالینی ابن سینا, 1996
Rice tablets which are also with trade names of “Celphos” and / or “Quick phos”, will release dangerous gas of phosphine (PH3), after ingestion and contact with gasterointestinal and even environmental humidity.
Abdolkarim Pezhomand   +2 more
doaj  

Soft and Stretchable Thienopyrroledione‐Based Polymers via Direct Arylation

open access: yesAdvanced Electronic Materials, EarlyView.
π‐conjugated polymers (CPs) that are concurrently soft and stretchable are needed for deformable electronics. This systematic molecular weight study on promising candidates for soft CPs, poly(indacenodithiophene‐co‐thienopyrroledione) (p(IDTC16‐TPDC8)) and poly(indacenodithienothiophene‐co‐thienopyrroledione) (p(IDTTC16‐TPDC8)) found that p(IDTC16 ...
Angela Lin   +9 more
wiley   +1 more source

Polymerization of Allene with Nickel(II) Phosphine Complexes

open access: bronze, 1969
Sango Kunichika   +2 more
openalex   +2 more sources

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