Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, EarlyView.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
Angewandte Chemie, EarlyView.A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye +4 more
wiley +2 more sources
Comprehensive Evaluation of Oxidation Resistance for Tertiary Phosphines Using Universal Machine Learning Interatomic Potential-Aided Molecular Dynamics Simulation. [PDF]
JACS AuSato T +8 more
europepmc +1 more source
Origin of Scission Selectivity for Phosphoranyl Radicals in Photoredox Catalysis. [PDF]
J Am Chem SocWearing ER +4 more
europepmc +1 more source
One-Step Photoreduction of Nitroarenes to Nitrosoarenes. [PDF]
Org LettKeech JA, Kushwaha ND, Bour JR.
europepmc +1 more source
Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction
Angewandte Chemie, EarlyView.Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess +3 more
wiley +2 more sources
Photocatalytic synthesis of phosphorothioates by sulfur transfer from thiosulfate. [PDF]
Chem SciBudeev A, Bon C, Sparr C.
europepmc +1 more source
Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie
Angewandte Chemie, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Photochemical Oxygen‐Atom‐Transfer Reactivity of Platinum(II) Peroxycarbonates
Angewandte Chemie, EarlyView.The coordination chemistry of metal–peroxycarbonate complexes (M(CO4)) remains poorly understood, with no reported studies of the photochemical reactivity of M(CO4) complexes. The platinum(II) peroxycarbonate complexes Pt(PPh3)2(CO4) and Pt(dppe)(CO4) (dppe = 1,2‐bis(diphenylphosphino)ethane) have been structurally characterized and are shown to ...
Meghan G. Sullivan +4 more
wiley +2 more sources