Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety. [PDF]
Cardiovasc Drugs Ther, 2023 Roy S, Kloner RA, Salloum FN, Jovin IS.
europepmc +1 more source
S1 Guideline: Therapy of generalized pustular psoriasis
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary The S1 guideline “Therapy of generalized pustular psoriasis (GPP)” is a German guideline developed in accordance with the criteria of the AWMF. The full version addresses clinical presentation, pathogenesis, diagnosis and differential diagnosis, comorbidities, and therapy.
Rotraut Mößner +17 more
wiley +1 more source
Терапевтический архив, 2009 Aim. To study the influence of long-term of vardenafil use on endothelial and erectile functions in patients with arteriogenic erectile dysfunction (ED) Subjects and methods. The study included 74 arteriogenic ED patients (mean age 57.4 ± 4.7 years).
Safar Israilovich Gamidov +7 more
doaj
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
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Phosphodiesterase-5 inhibitors for cerebral small vessel disease-related ischemic stroke and cognitive decline: systematic review and meta-analysis. [PDF]
Front NeurolYan L +5 more
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Meta-analysis examining phosphodiesterase-5 inhibitors in heart failure with preserved ejection fraction. [PDF]
Proc (Bayl Univ Med Cent), 2022 Adhikari G +10 more
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Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
The FEBS Journal, EarlyView.PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury
, 2014 Developing therapeutics for traumatic brain injury remains a challenge for all stages of recovery. The pathological features of traumatic brain injury are diverse, and it remains an obstacle to be able to target the wide range of pathologies that vary ...
Atkins, Coleen M +3 more
core +1 more source
PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation
International Journal of Dermatology, EarlyView.This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad +2 more
wiley +1 more source
A 10,000-Foot View at Survival and Treatment with Phosphodiesterase-5 Inhibitors in Interstitial Lung Disease Pulmonary Hypertension. [PDF]
Am J Respir Crit Care MedShlobin OA, Piccari L.
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