Results 231 to 240 of about 124,093 (287)

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 2128-2144, July 2026.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Real‐World Long‐Term Outcomes of Rezūm Therapy for Large‐Volume Benign Prostatic Hyperplasia: A Multicenter Cohort Study

LUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 4, July 2026.
ABSTRACT Objectives Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in aging men. Patients with large prostates (≥ 80 mL) often experience more severe symptoms and have limited minimally invasive treatment options.
Liberty Liu, Mario Henrique Bitar Siqueira, Naeem Bhojani, Bilal Chughtai, Kevin C. Zorn, Luca Cindolo, Giovanni Ferrari, Katherine Lajkosz, Eviatar Fields, Dean Elterman   +9 more
wiley   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, Volume 604, Issue 13, Page 5236-5259, 1 July 2026.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

[Phosphodiesterase 5 inhibitors for the treatment of heart failure: a systematic review and meta-analysis]. [PDF]

Arch Cardiol Mex
Monzón-Herrera R, Listorti F, Vensentini N, Mariani J.   +3 more
europepmc   +1 more source

Phosphodiesterase 5 Inhibitors from Derris scandens

Planta Medica, 2018
AbstractPhosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of Derris scandens stem showed phosphodiesterase 5 inhibitory activity with an IC50 value of about 7 µg/mL.
Nattiya, Chaichamnong, Prapapan, Temkitthawon, Nantaka, Khorana, Prompan, Pitpakdeeanan, Pornnarin, Taepavarapruk, Nitra, Nuengchamnong, Yuthana, Siriwattanasathien, Apichart, Suksamrarn, Kornkanok, Ingkaninan   +8 more
openaire   +3 more sources

New Avenues for Phosphodiesterase Inhibitors in Asthma

Journal of Experimental Pharmacology, 2021
Maria Gabriella Matera,1 Josuel Ora,2 Francesco Cavalli,2 Paola Rogliani,2,3 Mario Cazzola3 1Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Respiratory Diseases Unit, “Tor Vergata&rdquo ...
Maria Gabriella Matera, Josuél Ora, Francesco Cavalli   +2 more
exaly   +2 more sources

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Recreational Use and Misuse of Phosphodiesterase 5 Inhibitors

Journal of the American Pharmacists Association: JAPhA, 2005
To characterize the rationale for and extent of phosphodiesterase (PDE) 5 inhibitor use in recreational settings, describe risks from such misuse, and discuss postexposure clinical management strategies.Published articles identified by searches through Medline, EMBASE, International Pharmaceutical Abstracts, and Toxline, from 1990 to March 2004, using ...
Kelly M Smith, Frank Romanelli
exaly   +3 more sources