Results 71 to 80 of about 124,093 (287)

A New Perspective on the Nitrate-Phosphodiesterase Type 5 Inhibitor Interaction.

, 2018
BACKGROUND Nitrates and nitrate-containing compounds are vasodilators used for the treatment of angina and heart failure. Phosphodiesterase type 5 inhibitors used for the treatment of erectile dysfunction are also vasodilators, and when taken together
Goggin, Paul, Irwin Goldstein, Paul Goggin, Osterloh, Ian, Goldstein, Irwin, Sadovsky, Richard, Parker, John D, Kloner, Robert A, Hackett, Geoffrey, Michael G. Kirby, Kirby, Michael G, Robert A. Kloner, John D. Parker, Geoffrey Hackett, Ian Osterloh, Richard Sadovsky   +15 more
core   +1 more source

SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension

ESC Heart Failure, Volume 12, Issue 2, Page 1416-1426, April 2025.
Abstract Aims SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N‐terminal pro‐brain natriuretic protein (NT‐proBNP) is an established biomarker of RV failure in PH. The present study investigated whether NT‐proBNP and SPARCL1 concentrations are associated with load ...
Oliver Dörr, Stanislav Keranov, Paulina van Wickern, Holger Nef, Christian Hamm, Pascal Bauer, Christian Troidl, Samuel Sossalla, Sandra Voss, Christoph Liebetrau, Manuel J. Richter, Henning Gall, Werner Seeger, Ardeschir Ghofrani, Athiththan Yogeswaran, Khodr Tello   +15 more
wiley   +1 more source

Cyclic Guanosine Monophosphate Signaling and Phosphodiesterase-5 Inhibitors in Cardioprotection

, 2012
Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in the pathophysiology of the heart and its modulation by drugs such as ...
Das, Anindita, Salloum, Fadi N., Kukreja, Rakesh C.   +2 more
core   +1 more source

Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver [PDF]

, 2009
Background The NO - cGMP system plays a key role in the regulation of sinusoidal tonus and liver blood flow with phosphodiesterase-5 (PDE-5) terminating the dilatory action of cGMP.
Deibert Peter, Peter Deibert, Wolfgang Kreisel, Schmidt René, Kreisel Wolfgang, Pannen, Benedikt, Kreisel, Wolfgang, Halverscheid, Leonie, Blum Hubert E, Blum, Hubert Erich Christoph, Deibert, Peter, Hubert E Blum, René Schmidt, Torsten Dunkern, Schmidt, René, Dunkern Torsten, Dunkern, Torsten, Pannen Benedikt HJ, Benedikt HJ Pannen, Halverscheid Leonie, Leonie Halverscheid   +20 more
core   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

APPLICATION OF PHOSPHODIESTERASE TYPE 5 INHIBITORS SILDENAFIL IN PATIENTS WITH PULMONARY HYPERTENSION

Евразийский Кардиологический Журнал, 2015
The key component of the pathogenesis of pulmonary hypertension (PH) is endothelial dysfunction with imbalance between vasodilators and vasoconstrictors and activation of the blood coagulation system.
T. V. Martynyuk, Z. H. Dadacheva, V. M. Paramonov, O. A. Arkhipova, S. N. Nakonechnikov, I. Ye. Chazova   +5 more
doaj   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. [PDF]

, 2013
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine ...
Baker, David A, Strath Malcolm, Maria Penzo, David A Baker, Hackett Fiona, Penzo, Maria, Blackman, Michael J, Michael J Blackman, David A. Baker (122252), Christine R Collins, Fiona Hackett (27620), Christine R. Collins, Strath, Malcolm, Withers-Martinez, Chrislaine, David A. Baker, Michael J. Blackman, Malcolm Strath (411645), Withers-Martinez Chrislaine, Penzo Maria, Chrislaine Withers-Martinez, Malcolm Strath, Collins Christine R., Hackett, Fiona, Fiona Hackett, Chrislaine Withers-Martinez (27619), Baker David A., Collins, Christine R, Christine R. Collins (191982), Michael J. Blackman (192013), Blackman Michael J., Maria Penzo (411646)   +30 more
core   +1 more source

Obesity and Erectile Dysfunction: From Bench to Clinical Implication

The World Journal of Men's Health, 2019
Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both condi-tions may share an internal pathologic environment, also known as common soil.
Ki Hak Moon, So Young Park, Yong Woon Kim   +2 more
doaj   +1 more source