Results 81 to 90 of about 124,093 (287)
Oral phosphodiesterase-5 inhibitors and sperm functions [PDF]
International Journal of Impotence Research, 2008 This review aims to elucidate the possible effects of phosphodiesterase-5 (PDE5) inhibitors on sperm functions. PDEs hydrolyze cyclic nucleotides, and together with adenylyl and guanylyl cyclase, which catalyze the formation of cAMP and cGMP, regulate the levels of these second messengers in cells.
openaire +2 more sources
Equine Veterinary Journal, EarlyView.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Key Features for Designing Phosphodiesterase-5 Inhibitors
, 2012 [[abstract]]"Phosphodiesterase superfamily is the key regulator of 3′,5′-cyclic guanosine monophosphate (cGMP) decomposition in human body. Phosphodiesterase-5 (PDE-5) inhibitors, sildenafil, vardenafil and tadalafil, are well known oral treatment for ...
;Chang, Tung-Ti;Huang, Hung-Jin;李桂仁;Lee, Kuei-Jen;Yu, Hsin Wei;Chen, Hsin-Yi;蔡輔仁;Tsai, Fuu-Jen;Sun, Mao-Feng;陳語謙;Chen, Calvin Yu-Chian
core
A Review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology [PDF]
, 2014 Background: Phosphodiesterase inhibitors are commonly used drugs. Specific phosphodiesterase inhibitors with anti-inflammatory properties are being assessed as dermatological treatments.Purpose: To describe important aspects of phosphodiesterase ...
Moustafa, Farah, Feldman, Steven R
core +1 more source
Pulmonary Circulation, 2020 Pulmonary Hypertension due to left heart disease is the most common type of Pulmonary Hypertension. Morbidity and mortality significantly increase once Pulmonary Hypertension is present.
Galo M. Sanchez Palacios +2 more
doaj +1 more source
Food Chemistry International, EarlyView.(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi +2 more
wiley +1 more source
Phosphodiesterase 5 inhibitors and nitrergic transmission - from zaprinast to sildenafil
, 2001 Phosphodiesterase 5 terminates the cellular actions of the second messenger molecule cyclic GMP; inhibitors of phosphodiesterase 5 will therefore increase and prolong the actions of endogenous substances that signal via the cyclic GMP pathway, including ...
Gibson, A
core
International Journal of Cancer, EarlyView.ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari +10 more
wiley +1 more source
How to evaluate the efficacy of the phosphodiesterase type 5 inhibitors
, 2012 Introduction. Several methods have been so far proposed to compare the effectiveness of the three available phosphodiesterase type 5 inhibitors (PDE5Is)
Chung, Eric +3 more
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective This study aimed to describe maternal and perinatal outcomes among pregnant women with echocardiographically high probability of pulmonary arterial hypertension (PAH) managed at a quaternary center and to compare outcomes between women with and without cardiac complications (CC).
Laura Belmont‐Rojo +6 more
wiley +1 more source