Results 111 to 120 of about 96,537 (297)

A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults

Aging Cell, EarlyView.
We derived a 25‐protein blood‐based frailty signature (proteomic frailty index, pFI) predictive of the cumulative frailty index. The pFI was validated across independent cohorts and was significantly associated with physical, clinical, and cognitive function, as well as incident mortality and dementia, highlighting its potential as a biomarker of ...
Sanish Sathyan, Fangyu Liu, Toshiko Tanaka, Luigi Ferrucci, Emmeline Ayers, B. Gwen Windham, Tina Gao, Erica F. Weiss, Julián Candia, Josef Coresh, Nir Barzilai, Sofiya Milman, Keenan A. Walker, Joe Verghese   +13 more
wiley   +1 more source

Management Strategies for Generalised Granuloma Annulare: A Systematic Review of Current and Emerging Therapies

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Generalised Granuloma Annulare (GGA) is a chronic inflammatory skin disorder with no standard treatment. Since the last review in 2013, new treatments and varied responses have highlighted the need for an updated synthesis to guide clinical decisions.
Luca Bettolini, Vincenzo Maione, Andrea Carugno, Giorgio Stabile, Antonio Podo Brunetti, Zeno Fratton, Enzo Errichetti, Nicola Zerbinati, Franco Rongioletti, Piergiacomo Calzavara‐Pinton, Mariateresa Rossi, Stefano Bighetti   +11 more
wiley   +1 more source

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source

An Update on Phosphodiesterase Mutations Underlying Genetic Etiology of Hearing Loss and Retinitis Pigmentosa

Frontiers in Genetics, 2018
Rahul Mittal, Nicole Bencie, James M. Parrish, George Liu, Jeenu Mittal, Denise Yan, Xue Zhong Liu, Xue Zhong Liu   +7 more
doaj   +1 more source

OPTICAL CHANGES OCCURRING DURING THE ACTION OF PHOSPHODIESTERASE ON OLIGONUCLEOTIDES DERIVED FROM DEOXYRIBONUCLEIC ACID

, 1956
M. Privat de Garilhe, M. Laskowski
openalex   +1 more source

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

A New Cyclic Phosphodiesterase Having a 3'-Nucleotidase Activity from Escherichia coli B

, 1964
Yasuhiro Anraku
openalex   +1 more source

Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis

Andrology, EarlyView.
Abstract Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endothelium, vasodilatation, and antifibrosis in various diseases.
Bocheng Tu, Kang Liu, Bo Wen, Peng Hu, Taotao Sun, Beining Li, Manan Sulaiman, Shujun Jiang, Tao Wang, Jihong Liu, Yang Luan   +10 more
wiley   +1 more source

The effect of topical and intraurethral alprostadil on erectile function: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Erectile dysfunction (ED) affects up to 50% of men over 40. While phosphodiesterase‐5 inhibitors (PDE5i) are the first line of medical treatment, they are not always effective. Alprostadil, available in injectable, topical, and intraurethral forms, offers an alternative treatment modality.
Iason Papadopoulos, Maksim Tishukov, Ioannis Sokolakis, Ioannis Katafigiotis, Ioannis Leotsakos, Markos Karavitakis, Julian Marcon, Christian G Stief, Nikolaos Pyrgidis   +8 more
wiley   +1 more source

The Separation of the Phosphodiesterase and Deoxyribonuclease II Activities of Bovine Spleen

, 1969
Mary K. Swenson, M. E. Hodes
openalex   +1 more source