Results 161 to 170 of about 96,537 (297)

Cyclic 3′,5′-Adenosine Monophosphate Phosphodiesterase of Escherichia coli [PDF]

, 1973
L. D. Nielsen, Denis Monard, H.V. Rickenberg   +2 more
openalex   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

PDE9A Promotes Calcium-Handling Dysfunction in Right Heart Failure via cGMP-PKG Pathway Suppression: A Mechanistic and Therapeutic Review. [PDF]

Int J Mol Sci
Thatcher S, Khalid A, Ahmed AB, Gill R, Kia A.   +4 more
europepmc   +1 more source

Effect of adenosine 3′,5′-cyclic monophosphate derivatives on α-amylase release, protein kinase and cyclic nucleotide phosphodiesterase activity from rat parotid tissue

, 1976
Fred R. Butcher, Molly Thayer, John M. Goldman   +2 more
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Specific cleavages inflicted by venom phosphodiesterase on superhelical phiX174 DNA.

, 1978
A. Earl Pritchard, M. Laskowski
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Prostacyclin Therapy as Adjunctive Treatment for Pulmonary Hypertension in Pediatric Heart Transplantation: A Case Report. [PDF]

Pediatr Transplant
Konduri A, Sonnen AJ, Lim HM, Schumacher KR, Peng DM, Sood V, Olive MK, McCormick AD.   +7 more
europepmc   +1 more source

Inhibitory effect of molecular moiety in papaverine structure on cyclic AMP-phosphodiesterase of smooth and cardiac muscles.

, 1978
Masayasu Kimura, Isami Waki, Ikuko Kimura   +2 more
openalex   +2 more sources

cGAS–STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

Cancer Science, EarlyView.
This study investigates the role of STING in photodynamic therapy (PDT) using talaporfin sodium. STING knockout reduced ROS generation and therapeutic efficacy, while combining a STING agonist with PDT enhanced antitumor effects. These findings suggest that STING regulates ROS homeostasis and can potentiate PDT outcomes.
Makiko Sasaki, Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Taketo Suzuki, Hirotada Nishie, Shigeki Fukusada, Naomi Sugimura, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka   +11 more
wiley   +1 more source