Results 231 to 240 of about 229,722 (383)

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

, 1982
James B. Hurley, Lubert Stryer
openalex   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases [PDF]

Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tang   +3 more
openalex   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Contractile Effects of Glucagon in Mouse Cardiac Preparations. [PDF]

Int J Mol Sci
Neumann J, Schmidt F, Braekow P, Kirchhefer U, Klimas J, Hadova K, Gergs U.   +6 more
europepmc   +1 more source

Metabolic products of microorganisms. 268. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. II. Minor components belonging to the obscurolide B to D series.

, 1993
M. RITZAU, SIEGRID PHILIPPS, Axel Zeeck, HUBERT HOFF, Hans Zähner   +4 more
openalex   +2 more sources

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Neurotherapeutics, 2014
M. Gurney, Emily C. D’Amato, A. Burgin
semanticscholar   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges. [PDF]

Front Oncol
Ghoflchi S, Nakhaei A, Abbasinezhad-Moud F, Jalili-Nik M, Cimino PJ.   +4 more
europepmc   +1 more source

The Study of Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. VI. The Study of Makyo-kanseki-to with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase

, 1992
Tamotsu NIKAIDO, Setsuko IIZUKA, Noriko OKADA, Takashi Kuge, Taichi OHMOTO   +4 more
openalex   +2 more sources