Results 231 to 240 of about 96,537 (297)

Meta-analysis of targeted drugs for pulmonary hypertension to improve exercise tolerance and associated factors in eisenmenger syndrome. [PDF]

J Cardiothorac Surg
Yuan Z, Wang Y, Wang J, Lai Y, Dan X, Wang J.   +5 more
europepmc   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Phosphodiesterase Inhibition and Immunotropic Activity of Dipyridamole Dynamic Derivatives. [PDF]

Curr Issues Mol Biol
Martynov A, Farber B, Katz A.
europepmc   +1 more source

What Does Iron Mean to an Oligodendrocyte?

Glia, Volume 73, Issue 9, Page 1784-1804, September 2025.
Main Points Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley   +1 more source

Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation. [PDF]

J Am Heart Assoc
Cedars A, Manlhiot C, Chinni BK, Opotowsky AR, Becker K, Le A, Khare P, Love Ko J, Everett A, Kutty S, Russell MW, Payne RM, Atz AM, McCrindle BW, Rathod RH, Lewis M, Goldberg D, Hill K, Ploutz M, Detterich J, Schumacher K, Whitehill R, Penny DJ, Cartoski M, Sullivan R, Files M, Garg R, Wagner J, Jacobsen R, Nowlen T, Fletcher S, Conway J, Kim GB, Wu F, Zak V.   +34 more
europepmc   +1 more source

Properties of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium

, 1977
Roger M. Weppelman, Larry D. Kier, B N Ames   +2 more
openalex   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
wiley   +1 more source

"Cyclic nucleotides in plants: from obscure messengers to central regulators". [PDF]

Front Plant Sci
Świeżawska-Boniecka B, Szmidt-Jaworska A.   +1 more
europepmc   +1 more source

Chromosome‐level genome of Zoysia sinica in the intertidal zone reveals genomic insights into waterlogging stress adaptation

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Zoysia sinica is a perennial grass that thrives in intertidal zones, even under extreme waterlogging stress. In this study, we present a high‐quality chromosome‐level genome assembly of Z. sinica, with a total size of 312.67 Mb. Through genome annotation, we identified 29,551 protein‐coding genes in the Z. sinica genome and re‐annotated 32,925,
Hyeonseon Park, Eunji Bae, Jae Gyeong Jung, Jaewook Kim, Bae Young Choi, Geungjoo Lee, Changsoo Kim, Donghwan Shim   +7 more
wiley   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source