Results 231 to 240 of about 216,066 (333)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Macitentan and phosphodiesterase-5 inhibitor alone or in combination in newly diagnosed pulmonary arterial hypertension: a pooled analysis. [PDF]

JHLT Open
McLaughlin VV, Sauvageot N, Hennessy B, Panjabi S, Paoli CJ, Linder J, Bayer B, Söderberg S, Gaine S, Lange TJ, Kim NH.   +10 more
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction. [PDF]

PLoS One
Hu Y, Hu H, Xu L, Tang X, Wang C, Lian Z, Xie C, Xie Z, Wang Q.   +8 more
europepmc   +1 more source

Disarming the Pathogen's Metabolic Weapon: A Novel Route to Durable Disease Resistance

Modern Agriculture, Volume 4, Issue 1, June 2026.
Two routes to sugar acquisition in pathogenic bacteria and corresponding ‘pathogen‐starvation’ strategies. TAL effectors activate plant SWEET transporters to promote sucrose efflux into the apoplast, which can be blocked by editing SWEET promoter effector‐binding elements to prevent TAL binding. The T3E AvrBs2 converts host UDP‐galactose into xanthosan,
Yixuan Mi, Yuheng Yang
wiley   +1 more source

Efficient Hydrolysis of Dichlorvos in Water by <i>Stenotrophomonas acidaminiphila</i> G1 and Methyl Parathion Hydrolase. [PDF]

Int J Mol Sci
Mei Q, Hua R.
europepmc   +1 more source

The Ubiquitin Ligase Zinc Finger SWIM Domain‐Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA‐7 Axis

Glia, Volume 74, Issue 5, May 2026.
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji, Bing Yang, Shumin Duan, Zhiping Wang, Xing Guo   +13 more
wiley   +1 more source

Alterations in cerebrospinal fluid levels of myelin- and oligodendrocyte-related proteins in sporadic Creutzfeldt-Jakob disease. [PDF]

Acta Neuropathol Commun
Maass F, Thomas C, Kurvits L, Hermann P, Schmitz M, Bähr M, Stadelmann C, Zechel S, Canaslan S, Zerr I.   +9 more
europepmc   +1 more source

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo, Huan Chen, Ali Wu, Weipu Mao, Sagar Barge, Seth L. Alper, Simon C. Robson, Weiqun Yu   +7 more
wiley   +1 more source

RETRACTION: Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma. [PDF]

Comput Math Methods Med
And Mathematical Methods In Medicine C.
europepmc   +1 more source