Results 291 to 300 of about 225,115 (385)

A phase IIb single-center study to assess the efficacy of apremilast for the treatment of nummular eczema. [PDF]

open access: yesJ Dtsch Dermatol Ges
Böhner A   +7 more
europepmc   +1 more source

Systemic treatment of immune checkpoint inhibitor‐induced psoriasis: Inference‐based guidance

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
When managing psoriasis, induced or exacerbated by ICI therapy for cancer, there are concerns regarding immunosuppression from systemic agents for the treatment of psoriasis and the potential impact on ICI efficacy. No direct, high‐level evidence exists to address these concerns.
Kim A. Papp   +14 more
wiley   +1 more source

Efficacy and safety of ME3183, an oral phosphodiesterase 4 inhibitor, in patients with plaque psoriasis

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
We assessed four different doses of ME3183, a novel phosphodiesterase 4 inhibitor, and placebo in 132 patients with moderate to severe plaque psoriasis. At Week 16, more patients receiving ME3183 achieved ≥75% reduction in baseline Psoriasis Area and Severity Index scores than those receiving placebo, with no new safety concerns.
Kim A. Papp   +5 more
wiley   +1 more source

Prostacyclin Therapy as Adjunctive Treatment for Pulmonary Hypertension in Pediatric Heart Transplantation: A Case Report. [PDF]

open access: yesPediatr Transplant
Konduri A   +7 more
europepmc   +1 more source

Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X‐Linked Hypophosphatemia in Mice

open access: yesJournal of Periodontal Research, EarlyView.
Effects of exogenous tissue‐nonspecific alkaline phosphatase (TNAP) were analyzed in the Hyp mouse model of X‐linked hypophosphatemia (XLH). Maxillary first molars were extracted from wild‐type (WT) and Hyp mice at 6 weeks, and collagen gel ± TNAP was placed in sockets. In one group of Hyp mice, submucosal injections of TNAP or saline were delivered at
Aonjittra Phanrungsuwan   +3 more
wiley   +1 more source

Isolation and characterization of PDE-I and II, the inhibitors of cyclic adenosine-3',5'-monophosphate phosphodiesterase.

open access: bronze, 1978
Yûji Enomoto   +5 more
openalex   +2 more sources

The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and Angiostrongylus vasorum infestation

open access: yesJournal of Small Animal Practice, EarlyView.
Objectives Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document changes in tricuspid regurgitation maximum pressure gradient (TR Max PG) in subsequent months and years, record ...
R. Turner   +3 more
wiley   +1 more source

ATP8B1 Deficiency Causes Phosphodiesterase 4-Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver. [PDF]

open access: yesLiver Int
Chang JC   +18 more
europepmc   +1 more source

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