Results 291 to 300 of about 229,722 (383)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Repositioning Triazoles as Phosphodiesterase-4 Inhibitors to Suppress COVID-19 Cytokine Storms and Fungal Co-Infections via Docking and Simulation. [PDF]

J Cell Mol Med
Almohaimeed HM, Chatterjee A, Alaqabawi MR, Alsulaimani F, Basri AM, Jafer A, Shater AF, Saleh FM, Dhara B, Uti DE, Alum EU.   +10 more
europepmc   +1 more source

Integrated GWAS and Fst analysis identify flowering‐time regulatory genes in maize

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Flowering time in maize is a complex quantitative trait regulated by multiple genes, and its genetic variation mechanisms remain to be fully elucidated. In this study, we phenotypically evaluated flowering‐related traits (days to tasseling, days to pollen shedding, days to silking) across six different environments using an association ...
Dong Wang, Zhuoya Gao, Mengyue Dong, Tuan Li, Wenjing Zhou, Jialei Ou, Shiya Zhang, Shuaishuai Zhang, Xian Dong, Yalan Li, Caihui Zhang, Jiahao Tie, Yinuo Wang, Gaoyang Sun, Huiling Xie, Weihua Li, Jihua Tang, Pengshuai Yan   +17 more
wiley   +1 more source

Divergent viral phosphodiesterases for immune signaling evasion. [PDF]

Cell Host Microbe
Doherty EE, Nomburg J, Adler BA, Lopez S, Hsieh K, Price N, Blount N, Doudna JA.   +7 more
europepmc   +1 more source

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

Editorial: Bridging Inflammation, Oxidative Stress, and Metabolic Dysfunction in Brain Disorders. [PDF]

Brain Sci
Akhtar A.
europepmc   +1 more source

AMMONIA PLUS ANOTHER FACTOR ARE NECESSARY FOR DIFFERENTIATION IN SUBMERGED CLUMPS OF DICTYOSTELIUM [PDF]

, 1979
David, Charles N., Sternfeld, John
core  

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Real-World Adherence and Persistence of Upfront Therapy in Patients with Pulmonary Arterial Hypertension in the United States. [PDF]

Pulm Ther
De Marco T, Paoli CJ, Croteau NS, Tang F, Farber HW.   +4 more
europepmc   +1 more source