Results 301 to 310 of about 225,115 (385)

Landscape and Climate‐Associated Selection in the Native and Widespread Bumblebee, Bombus terrestris

Molecular Ecology, EarlyView.
ABSTRACT Anthropogenic land‐use and climate change pose novel selection pressures on bees, yet their evolutionary responses in terms of morphological or physiological adaptations remain unclear. While adaptive responses are expected, these may be constrained by gene flow when changes in selection pressures are spatially heterogeneous.
Cecilia Kardum Hjort, Rachael Y. Dudaniec, Peter Olsson, Johan Ekroos, Henrik G. Smith   +4 more
wiley   +1 more source

A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer's disease. [PDF]

J Prev Alzheimers Dis
Greeley D, Nash M, Herskowitz B, Kim F, Rock J, Prins N, Kim S, Xi T, Busam JA, Tete B, Choung JJ, Sha SJ.   +11 more
europepmc   +1 more source

Inhibition of Cyclic AMP Phosphodiesterase Activity by Ecarazine Hydrochloride, Hydralazine and Their Metabolites

, 1979
Akio Ishii, Kazuhiro Kubo, Takashi Deguchi, Masao Tanaka   +3 more
openalex   +2 more sources

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata

Plant, Cell &Environment, EarlyView.
ABSTRACT Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore assays, this study aimed at providing a holistic description of maize root responses to EPNs and to assess ...
Arletys M. Verdecia‐Mogena, Paul A. Himmighofen, Pierre Mateo, Keerthi Divakaran, Mirco Hecht, Rimjhim R. Choudhury, Christian Parisod, Christelle A. M. Robert   +7 more
wiley   +1 more source

Correction for Singh et al., Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Effects of Roflumilast on Exacerbations and Lung Function in COPD Patients with Bronchiectasis. [PDF]

Chonnam Med J
Lee JK, Yoon CS, Kho BG, Kim TO, Shin HJ, Kwon YS, Kim YI, Lim SC.   +7 more
europepmc   +1 more source

Inhibitors of cyclic nucleotide phosphodiesterases produced by streptomyces. IV. Inhibition of cyclic nucleotide phosphodiesterases by reticulol.

, 1977
Yoshio Furutani, TOMIO TAKEUCHI, HAMAO UMEZAWA   +2 more
openalex   +2 more sources

Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years

Pediatric Dermatology, EarlyView.
ABSTRACT Two 4‐week, phase 2, open‐label, maximal usage pharmacokinetic (PK) and safety studies of once‐daily roflumilast cream 0.3% (a potent phosphodiesterase 4 inhibitor) were conducted in children aged 2–5 years and 6–11 years with psoriasis. Evidence of systemic exposure to roflumilast and its active N‐oxide metabolite was seen in most patients ...
Adelaide A. Hebert, Shireen V. Guide, Vlada Groysman, Mercedes E. Gonzalez, Daisy Blanco, Vivian Laquer, Melissa S. Seal, Archie Thurston, David Krupa, Scott Snyder, Patrick Burnett, David H. Chu, David R. Berk, Robert C. Higham   +13 more
wiley   +1 more source

Mechanism of Activation of a Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase from Bovine Heart by Calcium Ions

, 1973
Tian Seng Teo, Jerry H. Wang
openalex   +1 more source

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

Experimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber, Kiana M. Schulze, Andrew G. Horn, Tyler E. McCoach, Zachary J. White, K. Sue Hageman, Stephanie E. Hall, Peter Sandner, Brad J. Behnke, Timothy I. Musch, David C. Poole   +10 more
wiley   +1 more source