Results 321 to 330 of about 225,115 (385)

Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types

The Journal of Physiology, EarlyView.
Abstract figure legend Photoreceptor loss has heterogeneous effects on functional retinal ganglion cell (RGC) types. A, illustrations of cross‐sections of rd10 retinae at different time points during degeneration. Left: P30, rod degeneration has commenced, cones are still unaffected.
Nadine Dyszkant, Jonathan Oesterle, Yongrong Qiu, Merle Harrer, Timm Schubert, Dominic Gonschorek, Thomas Euler   +6 more
wiley   +1 more source

Withdrawal: RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β₂-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells. [PDF]

J Biol Chem
Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD.   +7 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Erectile Dysfunction Drugs as Potential Therapy for Cognitive Decline: Preclinical and Translational Evidence. [PDF]

Cells
Ricciarelli R.
europepmc   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Management of treatment-resistant acquired perforating dermatosis with apremilast: A novel therapeutic approach. [PDF]

JAAD Case Rep
Zaidi H, Khan A, Sinha S, Sloan B, Aiudi D, Weston G.   +5 more
europepmc   +1 more source

Dietary Nitrate Prevents Cardiac Dysfunction in HFrEF by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aims Impaired cardiac function, reduced nitric oxide (NO) bioavailability, and inflammation are key contributors to the pathogenesis and progression of heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate whether dietary inorganic nitrate supplementation can attenuate cardiac dysfunction and adverse remodeling ...
Miho Shimari, Gaia Picozzi, Ariela Boeder, Drielle Dantas Guimarães, Zhengbing Zhuge, Jon O. Lundberg, Mattias Carlstrom, Lars H. Lund, Daniel C. Andersson, Gianluigi Pironti   +9 more
wiley   +1 more source

Ensifentrine Plus a Long-Acting Muscarinic Antagonist in COPD: A Trifunctional Dual Bronchodilation Perspective. [PDF]

Drugs
Cazzola M, Page CP, Calzetta L, Martinez FJ, Rogliani P, Matera MG.   +5 more
europepmc   +1 more source

Sexual function in adolescence after childhood hypospadias repair: a patient‐reported outcome study

BJU International, Volume 136, Issue 5, Page 843-847, November 2025.
Objective To present data on sexual function in post‐pubertal patients after hypospadias surgery in childhood. Patients and Methods We assessed 169 (96 distal, 20 midshaft, 53 proximal) patients with hypospadias born between 1991 and 2003, who underwent surgery before the age of 5 years.
Annaleena Anttila, Niklas Pakkasjärvi, Seppo Taskinen   +2 more
wiley   +1 more source

Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions. [PDF]

Int J Mol Sci
Vu SP, Veit K, Sadikot RT.
europepmc   +1 more source