Results 61 to 70 of about 93,838 (303)

Sugar‐sensing swodkoreceptors and swodkocrine signaling

Animal Models and Experimental Medicine, EarlyView.
Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
wiley   +1 more source

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond   +4 more
wiley   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo   +9 more
wiley   +1 more source

Efficacy and safety of apremilast and phototherapy versus phototherapy only in psoriasis vulgaris

The Journal of Dermatology, Volume 49, Issue 12, Page 1211-1220, December 2022., 2022
Abstract Phototherapy and apremilast (oral phosphodiesterase‐4 inhibitor) are well‐known in the treatment of moderate to severe psoriasis vulgaris. However, current evidence on the efficacy and safety of their combination is not sufficient. This multicenter, randomized controlled study compared the efficacy and safety between phototherapy as ...
Akimichi Morita, Yukie Yamaguchi, Chiharu Tateishi, Kyoko Ikumi, Aya Yamamoto, Haruna Nishihara, Daisuke Hayashi, Yukihiko Watanabe, Yuko Watanabe, Ayano Maruyama, Koji Masuda, Daisuke Tsuruta, Norito Katoh   +12 more
wiley   +1 more source

Evaluating aminophylline and progesterone combination treatment to modulate contractility and labor‐related proteins in pregnant human myometrial tissues

Pharmacology Research & Perspectives, 2021
Progesterone (P4) and cyclic adenosine monophosphate (cAMP) are regarded as pro‐quiescent factors that suppress uterine contractions during pregnancy.
Pei F. Lai, Roger C. Young, Rachel M. Tribe, Mark R. Johnson   +3 more
doaj   +1 more source

Effect of Quazodine on Phosphodiesterase

Experimental Biology and Medicine, 1971
SummaryQuazodine (6,7-dimethoxy-4-ethylquinazoline, MJ 1988) was up to 6 times as potent as theophylline in inhibiting PDE partially purified from a number of rabbit tissues and beef brain. As with theophylline, inhibition of PDE could be the underlying mechanism for the bronchodilator and cardiovascular effects of quazodine.
Browder Hp, Amer Ms
openaire   +3 more sources

Regioselective C‐H Thio‐ and Selenocyanation of Pyrazolo[1,5‐a]pyrimidines

Chemistry – An Asian Journal, EarlyView.
A metal‐free, N‐chlorosuccinimide (NCS) mediated, highly efficient, and regioselective C−H thiocyanation and C−H selenocyanation of pyrazolo[1,5‐a]pyrimidines are achieved under mild reaction conditions for the synthesis of a wide variety of 3‐thiocyanato‐ and 3‐selenocyanatopyrazolo[1,5‐a]pyrimidines in good to excellent yield up to 99 %.
Paramita Pattanayak, Harshil Khandelwal, Shreeja Basappa, Tanmay Chatterjee   +3 more
wiley   +1 more source

The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

Frontiers in Pharmacology, 2022
Age-related cardiovascular diseases (CVDs) remain among the leading global causes of death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its pathology.
Keivan Golshiri, Ehsan Ataei Ataabadi, Annika A. Jüttner, Gretchen L. Snyder, Robert E Davis, Amy Lin, Lei Zhang, René de Vries, Ingrid M Garrelds, Frank P. J. Leijten, A. H. Jan Danser, Anton J. M. Roks   +11 more
doaj   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Phosphodiesterase 4D: an enzyme to remember [PDF]

British Journal of Pharmacology, 2015
Cyclic adenosine monophosphate (cAMP) is one of the second messengers critically involved in the molecular mechanisms underlying memory formation. In the CNS, the availability of cAMP is tightly controlled by phosphodiesterase 4 (PDE4), a family of enzymes that degrades the cyclic nucleotide to inactive AMP.
RICCIARELLI, ROBERTA, FEDELE, ERNESTO
openaire   +4 more sources