Results 61 to 70 of about 225,115 (385)

Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]

, 1994
This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
core   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Enantiodivergent Synthesis of (R)- and (S)-Rolipram

Molecules, 1998
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric ...
Esteban Pombo-Villar, Hans-Peter Weber, Friedrich Schürch, Thomas Müller, Thomas H. Keller, Edmond Bacher, Luigi LaVecchia, Joachim Demnitz   +7 more
doaj   +1 more source

Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

Biomolecules, 2020
Antisense oligonucleotides conjugated with boron clusters (B-ASOs) have been described as potential gene expression inhibitors and carriers of boron for boron neutron capture therapy (BNCT), providing a dual-action therapeutic platform. In this study, we
Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus, Zbigniew Lesnikowski, Barbara Nawrot   +5 more
doaj   +1 more source

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates [PDF]

, 2016
Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was
Alagille, David, Flores, Hubert, Han, Junbin, Jin, Hongjun, Liu, Hui, Perlmutter, Joel S, Su, Yi, Tamagnan, Gilles, Tu, Zhude, Yang, Hao, Yue, Xuyi   +10 more
core   +2 more sources

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

International Journal of Neuropsychopharmacology, 2016
Background: The fronto-striatal circuits are the common neurobiological basis for neuropsychiatric disorders, including schizophrenia, Parkinson’s disease, Huntington’s disease, attention deficit hyperactivity disorder, obsessive-compulsive disorder, and
Pim R. A. Heckman, M. V. van Duinen, E. Bollen, A. Nishi, L. Wennogle, A. Blokland, J. Prickaerts   +6 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Nutrient addition modifies phosphatase activities along an altitudinal gradient in a tropical montane forest in Southern Ecuador

Frontiers in Earth Science, 2016
Atmospheric nutrient deposition and climate change are expected to endanger the diversity of tropical forest ecosystems. Nitrogen (N) deposition might influence nutrient fluxes beyond the N cycle by a concomitant increased demand for other nutritional ...
Karla eDietrich, Elena eSpoeri, Yvonne eOelmann   +2 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source