Results 41 to 50 of about 116,729 (252)

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

Frontiers in Pharmacology, 2021
3′,5′-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines.
Roberta Kurelic, Paula F. Krieg, Jana K. Sonner, Gloria Bhaiyan, Gustavo C. Ramos, Gustavo C. Ramos, Stefan Frantz, Stefan Frantz, Manuel A. Friese, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +10 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Influence of metabolism modifiers of cyclic nucleotides on contractility of right ventricle of rat heart with intact and removed endocardial endothelium [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Endocardial endothelium, a natural biological barrier between circulating blood in heart ventricle and cells, creates a complex yet finely tuned balance of interactions with the immediate environment. Objective. We investigated the roles
Savić Slađana, Miletić Milanka, Nestorović Vojkan, Trajković Goran, Smiljić Sonja, Radović Dragica   +5 more
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases

Frontiers in Pharmacology, 2021
Selective phosphodiesterase (PDE) inhibitors are a class of nonsteroid anti-inflammatory drugs for treating chronic inflammatory diseases. Modulation of systemic and airway inflammation is their pivotal mechanism of action.
Theerasuk Kawamatawong
doaj   +1 more source

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

Angewandte Chemie, EarlyView.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong, Victor Dubois, Jamie Y. Lam, Yitzhak Tor   +3 more
wiley   +2 more sources

The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial

, 2021
Background: Patients with schizophrenia have significant cognitive deficits, which may profoundly impair quality of life. These deficits are also evident at the neurophysiological level with patients demonstrating altered event-related potential in ...
Sukhi Shergill, Tolga Uz, Max Tsai, Lorena Valdearenas, James Gilleen, Steve C Williams, Frank Ogrinc, Sarah Kerins, Judith Nottage, Farah Yakub, Mitul A Mehta, Gez Lahu, Dominic Ffytche   +12 more
core   +1 more source

Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity.
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R. Hemnes, Joseph A. Hill, JoAnn Lindenfeld, Sanjiv J. Shah, Lynne W. Stevenson, Thomas J. Wang, Deepak K. Gupta   +11 more
doaj   +1 more source

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Spinocerebellar ataxia with axonal neuropathy:consequence of a Tdp1 recessive neomorphic mutation? [PDF]

, 2007
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and the 3' end of DNA.
Choi, Kunho, Bhattacharjee, Meenakshi B, Northrop, Jennifer L, Champoux, James J, Huang, Cheng, Salih, Mustafa A M, Takashima, Hiroshi, Arimura, Kimiyoshi, Izumo, Shuji, Interthal, Heidrun, Inoue, Ken, Armstrong, Dawna L, Hirano, Ryuki, Umehara, Fujio, Boerkoel, Cornelius F, Nakamura, Tomonori, Deguchi, Kimiko   +16 more
core   +1 more source