Results 41 to 50 of about 161,329 (309)

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation

mBio, 2017
The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira, Clémentine Dressaire, Susana Barahona, Lisete Galego, Volkhard Kaever, Urs Jenal, Cecília M. Arraiano   +6 more
doaj   +1 more source

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,, Bulgakov, Roman,, Haastert, Peter J.M. van,, Jastorff, Bernd,, Kesbeke, Fanja,, Morr, Michael,, Petridis, Georg,, Seela, Frank,, Stec, Wojciech J.,   +8 more
core   +2 more sources

Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Frontiers in Immunology, 2019
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by heterogeneous clinical symptoms including gradual muscle weakness, fatigue, and cognitive impairment.
Melissa Schepers, Melissa Schepers, Assia Tiane, Assia Tiane, Dean Paes, Dean Paes, Selien Sanchez, Ben Rombaut, Elisabeth Piccart, Elisabeth Piccart, Bart P. F. Rutten, Bert Brône, Niels Hellings, Jos Prickaerts, Tim Vanmierlo, Tim Vanmierlo   +15 more
doaj   +1 more source

An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis

Frontiers in Microbiology, 2023
Nucleotide second messengers play an important role in bacterial adaptation to environmental changes. Recent evidence suggests that some of these regulatory molecular pathways were conserved upon the degenerative evolution of the wall-less mycoplasmas ...
Xifang Zhu, Xifang Zhu, Xifang Zhu, Eric Baranowski, Zhiyu Hao, Xixi Li, Gang Zhao, Yaqi Dong, Yingyu Chen, Changmin Hu, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Christine Citti, Aiping Wang, Aiping Wang, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +20 more
doaj   +1 more source

Soil enzyme activities in the rhizosphere of field-grown sugar beet inoculated with the biocontrol agent Pseudomonas fluorescens F113 [PDF]

, 1998
The original publication is available at www.springerlink.com . Copyright Springer DOI : 10.1007/s003740050397Pseudomonas fluorescens F113, which produces the antimicrobial compound 2,4-diacetylphloroglucinol is a prospective biocontrol agent.
Lynch, J.M., Moenne-Loccoz, Y., Naseby, D.C., O'Gara, F., Powell, J.   +4 more
core   +1 more source

Influence of metabolism modifiers of cyclic nucleotides on contractility of right ventricle of rat heart with intact and removed endocardial endothelium [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Endocardial endothelium, a natural biological barrier between circulating blood in heart ventricle and cells, creates a complex yet finely tuned balance of interactions with the immediate environment. Objective. We investigated the roles
Savić Slađana, Miletić Milanka, Nestorović Vojkan, Trajković Goran, Smiljić Sonja, Radović Dragica   +5 more
doaj   +1 more source

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity [PDF]

, 2016
Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4,5 and 9 could alleviate the
Baillie, George S., Cameron, Ryan T., Day, Jon P., Parachikova, Anna I., Whiteley, Ellanor   +4 more
core   +1 more source

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

Frontiers in Pharmacology, 2021
3′,5′-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines.
Roberta Kurelic, Paula F. Krieg, Jana K. Sonner, Gloria Bhaiyan, Gustavo C. Ramos, Gustavo C. Ramos, Stefan Frantz, Stefan Frantz, Manuel A. Friese, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +10 more
doaj   +1 more source

The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence [PDF]

, 2019
Purpose: Interleukin (IL)-8 is a proinflammatory C-X-C chemokine involved in inflammation underling cardiac diseases, primary or in comorbid condition, such diabetic cardiomyopathy (DCM).
Antinozzi, C., Basili, S., Colletti, M., Corinaldesi, C., Crescioli, C., Di Luigi, L., Filardi, T., Giannattasio, S., Lenzi, A., Morano, S., Scolletta, S.   +10 more
core   +1 more source

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +1 more source